Clinical Evidence of the Role of Histamine in Heart Failure ∗

Kitakaze, Masafumi

doi:10.1016/j.jacc.2016.01.046

Cited by 10 publications

(8 citation statements)

References 16 publications

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“…Drugs like Famotidine (tradename; Pepcid) are histamine receptor antagonists that are routinely used to treat, and prevent certain types ulcers, and to treat conditions that cause the stomach to produce too much acid, and also to treat gastroesophageal reflux disease condition. Clinical evidence of the role of histamine in heart has been well documented, and histamine receptor antagonist in hypertension are cardioprotective [15][16][17]. Interestingly, HCQ is unique in the sense that, at low doses, it mitigates or blunts both the virus's direct effects, as well as the immune reaction/response.…”

Section: Introductionmentioning

confidence: 99%

Multi-organ damage by covid-19: congestive (cardio-pulmonary) heart failure, and blood-heart barrier leakage

Tyagi

Singh

2021

Mol Cell Biochem

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is caused by a coronavirus that is also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and is generally characterized by fever, respiratory inflammation, and multi-organ failure in susceptible hosts. One of the first things during inflammation is the response by acute phase proteins coupled with coagulation. The angiotensinogen (a substrate for hypertension) is one such acute phase protein and goes on to explain an association of covid-19 with that of angiotensin-converting enzyme-2 (ACE2, a metallopeptidase). Therefore, it is advisable to administer, and test the efficacy of specific blocker(s) of angiotensinogen such as siRNAs or antibodies to covid-19 subjects. Covid-19 activates neutrophils, macrophages, but decreases T-helper cells activity. The metalloproteinases promote the activation of these inflammatory immune cells, therefore; we surmise that doxycycline (a metalloproteinase inhibitor, and a safer antibiotic) would benefit the covid-19 subjects. Along these lines, an anti-acid has also been suggested for mitigation of the covid-19 complications. Interestingly, there are three primary vegetables (celery, carrot, and long-squash) which are alkaline in their pH-range as compared to many others. Hence, treatment with fresh juice (without any preservative) from these vegies or the antioxidants derived from purple carrot and cabbage together with appropriate anti-coagulants may also help prevent or lessen the detrimental effects of the covid-19 pathological outcomes. These suggested remedies might be included in the list of putative interventions that are currently being investigated towards mitigating the multi-organ damage by Covid-19 during the ongoing pandemic.

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Section: Introductionmentioning

confidence: 99%

Multi-organ damage by covid-19: congestive (cardio-pulmonary) heart failure, and blood-heart barrier leakage

Tyagi

Singh

2021

Mol Cell Biochem

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“…Our study has several strengths and differs from previous studies in many ways. The present study is the first to show the association of PPIs with lower cardiac mortality in HF patients, considering the presence of upper gastrointestinal tract disease and the use of antiplatelet agents and anticoagulants, with a relatively long follow‐up period (≈3 years).…”

Section: Discussionmentioning

confidence: 89%

“…It was reported recently that H2RAs are associated with the blockade of right and left ventricular remodeling and reduce the incidence of HF in persons without cardiovascular disease . Myocardial histamine H 2 receptor activation may promote cardiac fibrosis and apoptosis in preclinical models, and the use of H2RAs may improve symptoms in HF patients .…”

Section: Introductionmentioning

confidence: 99%

Associations of Acid Suppressive Therapy With Cardiac Mortality in Heart Failure Patients

Yoshihisa

Takiguchi

Kanno

et al. 2017

JAHA

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BackgroundIt has been recently reported that histamine H2 receptor antagonists (H2RAs) are associated with impairment of ventricular remodeling and incident heart failure. In addition, favorable pleiotropic effects and adverse effects of proton pump inhibitors (PPIs) on cardiovascular disease have also been reported. We examined the associations of acid suppressive therapy using H2RAs or PPIs with cardiac mortality in patients with heart failure.Methods and ResultsIn total, 1191 consecutive heart failure patients were divided into 3 groups: a non–acid suppressive therapy group (n=363), an H2RA group (n=164), and a PPI group (n=664). In the follow‐up period (mean 995 days), 169 cardiac deaths occurred. In the Kaplan–Meier analysis, cardiac mortality was significantly lower in the PPI group than in the H2RA and non–acid suppressive therapy groups (11.0% versus 21.3% and 16.8%, respectively; log‐rank P=0.004). In the multivariable Cox proportional hazards analysis, use of PPIs, but not H2RAs, was found to be an independent predictor of cardiac mortality (PPIs: hazard ratio 0.488, P=0.002; H2RAs: hazard ratio 0.855, P=0.579). The propensity‐matched 1:1 cohort was assessed based on propensity score (H2RAs, n=164; PPIs, n=164). Cardiac mortality was significantly lower in the PPI group than in the H2RA group in the postmatched cohort (log‐rank P=0.025). In the Cox proportional hazards analysis, the use of PPIs was a predictor of cardiac mortality in the postmatched cohort (hazard ratio 0.528, P=0.028).Conclusions PPIs may be associated with better outcome in patients with heart failure.

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“…Conversely, the majority of the literature on H2 blockers indicate favorable effects of medication on cardiovascular outcomes. It has been demonstrated that myocardial histamine H2 receptor activation might promote cardiac fibrosis and apoptosis in preclinical models; thus, H2 blockers may have cardioprotective effects [ 15 , 16 , 17 ]. H2 blockers have been shown to improve symptoms in patients with heart failure and reduce the incidence of heart failure in persons without cardiovascular disease [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that myocardial histamine H2 receptor activation might promote cardiac fibrosis and apoptosis in preclinical models; thus, H2 blockers may have cardioprotective effects [ 15 , 16 , 17 ]. H2 blockers have been shown to improve symptoms in patients with heart failure and reduce the incidence of heart failure in persons without cardiovascular disease [ 17 , 18 ]. Additionally, H2 blocker-mediated improvements in anaerobic myocardial metabolism protect against ischemia and reperfusion injury in an animal ischemia/reperfusion model [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Prediction of Long-Term Outcomes in ST-Elevation Myocardial Infarction and Non-ST Elevation Myocardial Infarction with and without Creatinine Kinase Elevation—Post-Hoc Analysis of the J-MINUET Study

Toyoda

Sakuma

Abe

et al. 2020

JCM

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Background: A Japanese prospective, nation-wide, multicenter registry (J-MINUET) showed that long-term outcomes were worse in non-ST elevation acute myocardial infarction (NSTEMI), diagnosed by increased cardiac troponin levels, compared to STEMI. This was observed in both non-STEMI with elevated creatine kinase (CK) (NSTEMI+CK) and non-STEMI without elevated CK (NSTEMI-CK). However, predictive factors for long-term outcomes in STEMI, NSTEMI+CK, and NSTEMI-CK have not been elucidated. Methods: Using the Cox proportional hazards model, we determined significant independent predictors of long-term outcomes from a total of 111 parameters evaluated in the J-MINUET study in each of our groups, including STEMI, NSTEMI+CK, and NSTEMI-CK. Then, we calculated the risk score using the regression coefficients for the determined independent predictors for the strict prediction of long-term outcomes. Results: Prognostic factors, as well as composite cardiovascular events and all-cause death, were different between STEMI, NSTEMI+CK, and NSTEMI-CK. Risk scores could effectively and powerfully predict both composite cardiovascular events and all-cause death in each group. Conclusions: The prediction of long-term outcomes using cored parameters of baseline demographics and clinical characteristics is feasible and could prove useful in establishing therapeutic strategies in patients with STEMI, NSTEMI+CK, and NSTEMI-CK.

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Clinical Evidence of the Role of Histamine in Heart Failure ∗

Cited by 10 publications

References 16 publications

Multi-organ damage by covid-19: congestive (cardio-pulmonary) heart failure, and blood-heart barrier leakage

Multi-organ damage by covid-19: congestive (cardio-pulmonary) heart failure, and blood-heart barrier leakage

Associations of Acid Suppressive Therapy With Cardiac Mortality in Heart Failure Patients

Prediction of Long-Term Outcomes in ST-Elevation Myocardial Infarction and Non-ST Elevation Myocardial Infarction with and without Creatinine Kinase Elevation—Post-Hoc Analysis of the J-MINUET Study

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