Clinical Experience of Luminescent Diagnostics of Precancerous Diseases and Cervical Cancer

Abstract

The article summarizes the experience of using luminescent diagnostics with the use of ytterbium porphyrin complexes in gynecology and oncology. A pharmaceutical composition based on the Yb complex of 2,4-dimethoxyhematoporphyrin IX was used as the luminescent markers within the infrared range. The determination of luminescence characteristics (luminescence intensity) was carried out using a laserfiber fluorimeter in the range of 900-1100 nm. A new method for diagnosis of cervical disease has been proposed. The method of luminescent diagnostics allows to conduct a survey of a large number of patients in a short time. The method of luminescent diagnostics using the ytterbium complexes of porphyrins is not invasive. The method can be used as a screening. Differences between normal and pathologically altered cervical tissue have been identified and differences between pathological changes in the cervix HSIL (CIN II, CIN III) and cervical cancer are reliable. Keywords:Cervical cancer, squamous cell carcinoma, diagnosis of cervical cancer, squamous intraepithelial lesions of high grade -HSIL, luminescent diagnostics, luminescing in the near infrared (NIR) spectral region, porphyrins, ytterbium complexes of porphyrins.

Diagnosis of Cervical Cancer Using Raman Spectroscopy

“…We have already used new high-tech methods to diagnose precancerous diseases of the cervix. In particular, we used the method of luminescent diagnostics to develop a technique for in vivo diagnosis of pathological changes in the cervix [2,3,6]. To diagnose cervical cancer using biopsy and surgical material, we used Raman spectrometry [4,5].…”