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The aim of the investigation was to evaluate the efficiency of immunohistochemical methods of diagnosis in complex examination of women with uterine factor infertility.Materials and Methods. A total of 100 patients aged 27 to 42 years were examined, in 59 of the women immunohistochemical markers (ER, PR, Кi-67, CD34, CD56, CD68, CD138, VEGF) were revealed.Results. The study showed significant reduction of CD56-positive cells in all the women, decreased or absent CD138 expression, increased CD34 expression and abnormal VEGF expression. Thus, immunohistochemical markers may serve as additional criteria for evaluation of receptor activity, the adequacy of proliferative and reparative functions of the endometrium prior to pregnancy planning.

The article summarizes the experience of using luminescent diagnostics with the use of ytterbium porphyrin complexes in gynecology and oncology. A pharmaceutical composition based on the Yb complex of 2,4-dimethoxyhematoporphyrin IX was used as the luminescent markers within the infrared range. The determination of luminescence characteristics (luminescence intensity) was carried out using a laserfiber fluorimeter in the range of 900-1100 nm. A new method for diagnosis of cervical disease has been proposed. The method of luminescent diagnostics allows to conduct a survey of a large number of patients in a short time. The method of luminescent diagnostics using the ytterbium complexes of porphyrins is not invasive. The method can be used as a screening. Differences between normal and pathologically altered cervical tissue have been identified and differences between pathological changes in the cervix HSIL (CIN II, CIN III) and cervical cancer are reliable. Keywords:Cervical cancer, squamous cell carcinoma, diagnosis of cervical cancer, squamous intraepithelial lesions of high grade -HSIL, luminescent diagnostics, luminescing in the near infrared (NIR) spectral region, porphyrins, ytterbium complexes of porphyrins.

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