The aim of the investigation was to evaluate the efficiency of immunohistochemical methods of diagnosis in complex examination of women with uterine factor infertility.Materials and Methods. A total of 100 patients aged 27 to 42 years were examined, in 59 of the women immunohistochemical markers (ER, PR, Кi-67, CD34, CD56, CD68, CD138, VEGF) were revealed.Results. The study showed significant reduction of CD56-positive cells in all the women, decreased or absent CD138 expression, increased CD34 expression and abnormal VEGF expression. Thus, immunohistochemical markers may serve as additional criteria for evaluation of receptor activity, the adequacy of proliferative and reparative functions of the endometrium prior to pregnancy planning.

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The article presents the results of laparoscopic correction of the failure of uterine scar after a cesarean section operation in 12 patients of reproductive age who are planning another pregnancy and having clinical symptoms that significantly impair the quality of life. The developed by ourselves three-stage reconstructive-plastic surgical program with the laparoscopic access in case of incompetence of the uterine scar contributed to an improvement in the quality of life in all subjects, pregnancy, and childbirth in 41,6% of patients. The use of laparoscopic techniques provided an improved visualization of anatomical structures (vessels, nerves, ureters, bladder), which led to a decrease in intraoperative blood loss, a reduction in the risk of damage to adjacent organs and the development of adhesions, and acceleration of postoperative rehabilitation of patients.