Clinical experiences with keratinocyte grafts

Donati, Lorenzo; Magliacani, G.; Bormioli, M; Signorini, M.; Preis, Franz Wilhelm Baruffaldi

doi:10.1016/0305-4179(92)90106-5

Cited by 48 publications

(22 citation statements)

References 17 publications

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“…(19). The introduction, during the past 20 years, of a variety of skin substitutes and of cultured keratinocytes has greatly improved the management of burned patients, especially those with extensive burns (21)(22)(23)(24)(25)(26).…”

Section: Discussionmentioning

confidence: 99%

Successful management of deep facial burns in a patient with extensive third‐degree burns: the role of a nanocrystalline silver dressing in facilitating resurfacing

Marazzi

Angelis

Ravizza

et al. 2007

International Wound Journal

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Full-thickness burns of the face are notoriously difficult to repair and their management poses a series of problems to the surgeon. We present the case of a 49-year-old man (only survivor of a catastrophic airport accident) with third-degree flame burns to >80% of total body surface area and extensive face damage who achieved a fully satisfactory outcome after a treatment plan based on gradual escharectomy followed by application of artificial dermis and, later, grafting with sheets of cultured keratinocytes. Re-epithelialisation was already visible at day 16 after admission and all facial wounds were closed by day 56, the treatment continuing on the scalp. Within 6 months of the accident, the patient had recovered functional and cosmetic features (including re-growth of skin appendages) that were beyond expectations. The use of nanocrystalline silver-coated dressings during the escharectomy and resurfacing phases was important, as part of a multifaceted strategy, in ensuring excellent antimicrobial control, thus avoiding the need for autologous grafting and contributing to a rapid healing and complete restoration of the face and head skin.

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Section: Discussionmentioning

confidence: 99%

Successful management of deep facial burns in a patient with extensive third‐degree burns: the role of a nanocrystalline silver dressing in facilitating resurfacing

Marazzi

Angelis

Ravizza

et al. 2007

International Wound Journal

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“…Sites chosen for CEA application included the trunk, upper and lower limbs, and depended on pattern of burn injury and surgeon preference. CEA application over joints, bony prominences, and perisphincteric regions were difficult to immobilize and avoided . In most instances, weight bearing surfaces such as the back were avoided to minimize shear, pressure, and CEA dislodgement.…”

Section: Resultsmentioning

confidence: 99%

“…In terms of dressings, most common contact layers used were Vaseline® petrolatum gauze and tulle gras . Other non‐adherent contact layers used include Adaptic™, N‐terface®, Comfeel®, and UrgoTul® .…”

Section: Resultsmentioning

confidence: 99%

A systematic review: Current trends and take rates of cultured epithelial autografts in the treatment of patients with burn injuries

Chong

Akbarzadeh³

et al. 2019

Wound Repair Regeneration

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Several issues persist in clinical translation and application of cultured epithelial autografts during treatment of patients with massive burn injuries. The aim of this systematic review is to determine (1) current practice and trends in clinical application and (2) clinical efficacy of cultured epithelial autografts. A structured literature search was performed in Ovid MEDLINE from 1946 and Ovid EMBASE from 1974 until present. All published peer‐reviewed randomized or non‐randomized clinical studies, cohort studies, prospective, or retrospective series involving human application of cultured epithelial autografts in the setting of burn injury were included. From 7,267 studies initially identified, 77 studies were included in the analysis. In 96% (74/77) of these series, the sample size was less than 100 patients. In 76.6% (59/77) publications, average burn treated exceeded 40% total body surface area. Overall, cultured epithelial autograft take rates reported in the literature were inconsistent and varied significantly from 0 to 100%. There was a recent trend for co‐application of cultured grafts with autologous skin grafts, achieving relatively high and consistent take rates of 73–96%. Results from cultured epithelial autograft application remained unpredictable. This technology remains an adjunct or biological dressing, and not an alternative to conventional split skin graft. However, it has contributed to wound closure and it has been life saving in selected circumstances. Skin tissue engineering should continue as the clinical need for skin replacement is foreseeable into the future.

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“…The initial motivation for the development of the CEA came from treating massive body surface area burns. 17 Since 1981, CEA also has been used for the coverage of wounds, such as large burn wounds, 18 burn scar excision, 19 leg ulcer, 20 donor sites of split-thickness skin, 21 and GCMN. 22 These clinical reports and our experience have shown that the CEA grafts take well on the dermal wound almost completely, with little scar formation, and shorten the healing period of the wounds compared with dermabrasion without CEA.…”

Section: Discussionmentioning

confidence: 99%

Comparative Treatment of Giant Congenital Melanocytic Nevi with Curettage or Er:YAG Laser Ablation Alone versus with Cultured Epithelial Autografts

Whang¹,

Kim²,

Song³

et al. 2005

Dermatologic Surgery

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Clinical experiences with keratinocyte grafts

Cited by 48 publications

References 17 publications

Successful management of deep facial burns in a patient with extensive third‐degree burns: the role of a nanocrystalline silver dressing in facilitating resurfacing

Successful management of deep facial burns in a patient with extensive third‐degree burns: the role of a nanocrystalline silver dressing in facilitating resurfacing

A systematic review: Current trends and take rates of cultured epithelial autografts in the treatment of patients with burn injuries

Comparative Treatment of Giant Congenital Melanocytic Nevi with Curettage or Er:YAG Laser Ablation Alone versus with Cultured Epithelial Autografts

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