Objectives
To determine whether noninvasive fractional flow reserve derived from computed tomography (FFRCT) predicts coronary revascularization and outcomes and whether its addition improves efficiency of referral to invasive coronary angiography (ICA) after coronary CT angiography (CTA).
Background
FFRCT may improve the efficiency of an anatomic CTA strategy for stable chest pain.
Methods
Observational cohort study of patients with stable chest pain enrolled in the PROMISE trial referred to ICA within 90 days after CTA. FFRCT was measured at a blinded core lab, and FFRCT results were unavailable to caregivers. We determined the agreement of FFRCT (positive if ≤0.80) with stenosis on CTA and ICA (positive if ≥50% left main or ≥70% other coronary artery), and predictive value for a composite of coronary revascularization or MACE (death, myocardial infarction, or unstable angina). We retrospectively assessed whether adding FFRCT ≤0.80 as a gatekeeper could improve efficiency of referral to ICA, defined as decreased rate of ICA without ≥50% stenosis and increased ICA leading to revascularization.
Results
FFRCT was calculated in 67% (181/271) of eligible patients (mean age 62 years, 36% women). FFRCT was discordant with stenosis in 31% (57/181) for CTA and 29% (52/181) for ICA. Most patients undergoing coronary revascularization had FFRCT ≤0.80 (91%, 80/88). FFRCT ≤0.80 was a significantly better predictor for revascularization or MACE than severe CTA stenosis (HR 4.3 [95% CI 2.4–8.9] versus 2.9 [1.8–5.1]; p=0.033). Reserving ICA for patients with FFRCT ≤0.80 could decrease ICA without ≥50% stenosis by 44%, and increase the proportion of ICA leading to revascularization by 24%.
Conclusion
In this hypothesis-generating study of patients with stable chest pain referred to ICA from CTA, FFRCT ≤0.80 was a better predictor of revascularization or MACE than severe stenosis on CTA. Adding FFRCT may improve efficiency of referral to ICA from CTA alone.