“…It is worth noting that most of the primary studies published to date and included in these three previous meta-analyses [ 12 , 13 , 79 ] had significant limitations. For example, most of them did not have an adequate control group or did not control for potential confounders ( Supplementary Materials ), all of which may affect the real effect of the exposition or intervention [ 80 , 81 , 82 , 83 ]; therefore, we excluded more than 50 of these studies in our systematic review [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ,…”