Clinical feasibility of Gd-EOB-DTPA-enhanced MR imaging for assessing liver function: validation with ICG tests and parenchymal cell volume

Modern radiotherapy techniques have enabled high focal doses of radiation to be delivered to patients with primary and secondary malignancies of the liver. The current clinical practice of radiation oncology has benefitted from decades of research that have informed how to achieve excellent local control and survival outcomes with minimal toxicities. Still, one of the most devastating consequences of radiation to the liver remains a challenge: radiation induced liver disease (RILD). Here, we will review the current understanding of classic and non-classic RILD from a clinical perspective, the evaluation and management of patients who are at risk of developing RILD, methods to reduce the likelihood of RILD using modern radiation techniques, and the diagnosis and treatment of radiation-related liver toxicities.

show abstract

“…75–77 As a corollary, Eovist enhancement as a measure of liver function is correlated with ICGR15 retention. 78, 79…”

Section: Functional Liver Imaging and Incorporation Into Radiation Plmentioning

confidence: 99%

Radiation-Induced Liver Disease and Modern Radiotherapy

Koay

Owen

Das

2018

Seminars in Radiation Oncology

102

View full text Add to dashboard Cite

show abstract

“…This finding was in accordance with that of previous reports. Several studies (28)(29)(30) showed that relative RLV calculated using CT or gadoxetic acidenhanced MRI could predict postoperative hepatic dysfunction. However, as RLV can evaluate liver function based on the qualitatively defined residual liver parenchyma volume, it fails to consider the function of each hepatocyte.…”

Section: Discussionmentioning

confidence: 99%

Assessing Liver Function in Liver Tumors Patients: The Performance of T1 Mapping and Residual Liver Volume on Gd-EOBDTPA-Enhanced MRI

et al. 2020

View full text Add to dashboard Cite

Purpose: To assess the performance of T1 mapping and residual liver volume (RLV) on Gd-EOBDTPA-enhanced MRI in pretreatment estimation of liver function in patients with liver tumors. Indocyanine green retention rate at 15 min (ICG R-15) was used as a reference standard. Methods: Ethical approval from the institutional review board and informed consent were obtained for this prospective study. We enrolled 155 patients with liver tumors who underwent pretreatment Gd-EOB-DTPA-enhanced MRI. T1 relaxation time before (T1-pre), 20 min after (T1-post) Gd-EOB-DTPA injection and RLV were measured. The absolute reduction (T1) and reduction rate (T1%) of T1 relaxation time, volume-assisted T1 (T1 * RLV) and volume-assisted T1% (T1% * RLV) were calculated accordingly. The correlation of MR parameters with ICG R-15 was determined using Spearman's rank correlation analysis. Patients were classified into the normal liver function (NLF) group if their ICG R-15 levels were <10% or otherwise into the abnormal liver function (ALF) group. Receiver operating characteristic (ROC) analysis was conducted to evaluate the performances of the MR parameters in predicting ALF.

show abstract

“…Prior studies have reported that liver parenchymal cell volume, measured by CT, and functional liver volume, estimated by magnetic resonance imaging with hepatobiliary-specific contrast agent, showed significant correlations with ICG R15. 15,16 In our study, we proposed FFLBWR to access functional liver volume in living donor candidates. It is wellknown that donor liver steatosis can reduce the functional hepatic volume.…”

Section: Discussionmentioning

confidence: 99%

Portal Vein Flow by Doppler Ultrasonography and Liver Volume by Computed Tomography in Living Donor Candidates: Correlation with Indocyanine Green Test

Lee

Kim

Lee³

et al. 2019

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: Our goal was to investigate the correlation between indocyanine green test results and imaging parameters in living liver donor candidates. Materials and Methods: Our study included 219 healthy donor candidates who were evaluated with Doppler ultrasonography (portal vein time average flow), computed tomography (liver volume), liver biopsy (fat fraction), and indocyanine green retention rate at 15 minutes. Results: Portal vein time average flow (r=-0.375), fat-free liver volume/body weight ratio (r =-0.239), and portal vein time average flow × fat-free liver volume/body weight ratio (r =-0.424) showed significant correlations with indocyanine green retention rate at 15 minutes (all P < .001). Conclusions: Imaging parameters were significantly correlated with indocyanine green retention rate at 15 minutes in living liver donor candidates.

show abstract

Clinical feasibility of Gd-EOB-DTPA-enhanced MR imaging for assessing liver function: validation with ICG tests and parenchymal cell volume

Cited by 7 publications

References 14 publications

Radiation-Induced Liver Disease and Modern Radiotherapy

Radiation-Induced Liver Disease and Modern Radiotherapy

Assessing Liver Function in Liver Tumors Patients: The Performance of T1 Mapping and Residual Liver Volume on Gd-EOBDTPA-Enhanced MRI

Portal Vein Flow by Doppler Ultrasonography and Liver Volume by Computed Tomography in Living Donor Candidates: Correlation with Indocyanine Green Test

Contact Info

Product

Resources

About