Clinical features and nail clippings in 52 children with psoriasis

Uber, Marjorie; Carvalho, Vânia Oliveira; Abagge, Kerstin Taniguchi; Imoto, Renata Robl; Werner, Betina

doi:10.1111/pde.13402

Cited by 20 publications

(12 citation statements)

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“…Recently, the use of nail clipping microscopy as a diagnostic tool for nail psoriasis has also been studied . Although there are many studies delineating the clinical features of nail psoriasis, very few have described the histopathological features, or tried to correlate the two.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11] Recently, the use of nail clipping microscopy as a diagnostic tool for nail psoriasis has also been studied. [12][13][14][15] Although there are many studies delineating the clinical features of nail psoriasis, very few have described the histopathological features, or tried to correlate the two. In an attempt to bridge this gap, this descriptive cross-sectional study was undertaken to study the histopathological features of nail psoriasis.…”

Section: Introductionmentioning

confidence: 99%

“…Comparative table with frequency of histopathological features8,9,12,14,15 PAS stain refers to the periodic acid-Schiff stain performed on tissue specimen to evaluate the presence of fungal elements. In the studies included here, both H&E and PAS stain were performed in all cases with two exceptions: Uber et al used only PAS stain with diastase in their study and Hanno et al stained only with H&E. The percentage of positive cases indicates the number of cases with presence of either hyphae, yeast forms or spores in the nail tissue.…”

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Clinical and histological spectrum of nail psoriasis: A cross‐sectional study

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical and histological spectrum of nail psoriasis: A cross‐sectional study

et al. 2018

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Section: Discussionmentioning

confidence: 97%

“…Onychomycosis is classified into five different types depending on the invaded location: distal lateral subungual, white superficial, proximal subungual, endonyx and total dystrophic. Uber et al 9 suggested that the presence of nondermatophyte onychomycosis in patients with psoriasis is combined with pitting and salmon patches on the nail. Having the hands constantly immersed in water can predispose to the development of chronic paronychia, resulting in poor nail growth, 10 infection with Pseudomonas aeruginosa 11 or onycholysis.…”

Section: Discussionmentioning

confidence: 99%

Liquid chromatography–tandem mass spectrometry is effective for analysis of ergosterol in fungal‐infected nails

Yang

2019

Clin Exp Dermatol

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Summary Background Identification of onychomycosis is mainly based on clinical diagnosis with auxiliary diagnostic methods such as potassium hydroxide (KOH) microscopy, periodic acid–Schiff staining or fungal culture. However, each method is limited by its sensitivity and specificity. Aim To develop a new test method using the common fungal end product, ergosterol, and investigate if it can be used as a new diagnostic tool. Methods We collected consecutive data from 20 participants with nail problems. Following clinical diagnosis, samples were taken for KOH microscopy and for mass spectrometry (MS) to check for the presence of ergosterol. Results Of the 20 cases collected, 7 were positive for fungal infection by MS. Four of these were already suspected to have onychomycosis, whereas one of the remaining three subjects was presumed to have dry nail and the other two to have onycholysis. The MS test seemed to be better at detecting combinations of nail conditions. Conversely, of the five patients clinically diagnosed as having onychomycosis, four had a positive MS result, whereas the fifth had negative results on both KOH and MS. Two other participants had a positive KOH test and were also found to have positive MS results. Conclusion Detection of the presence of ergosterol by MS seems to be a useful tool for confirming onychomycosis. However, further studies are needed to verify the sensitivity and specificity of this MS method.

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Acquired Disorders of the Nails and Nail Unit

Pasch,

Richert,

Iorizzo

2024

Rook's Textbook of Dermatology

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Diseases of the nail unit may have numerous causes that reflect dermatology as a whole but often present in a unique way. This chapter attempts to increase insight into the pathophysiology of the expression of nail abnormalities. It also focuses on many groups of nail disease, including traumatic nail disorders, tumours of and around the nail unit, perionychial disorders, age‐related nail abnormalities, and frequent dermatoses affecting the nails, such as nail psoriasis, eczema and lichen planus. Imaging of the nail, nail surgery and some cosmetic aspects of nail care are also discussed.

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Clinical features and nail clippings in 52 children with psoriasis

Abstract: There seems to be a correlation between some microscopic nail features in children with psoriasis and their PASI and NAPSI scores, so nail clippings from children with suspected psoriasis may help with diagnosis, especially in the presence of neutrophils, and in excluding onychomycosis.

Cited by 20 publications

References 20 publications

Clinical and histological spectrum of nail psoriasis: A cross‐sectional study

Clinical and histological spectrum of nail psoriasis: A cross‐sectional study

Liquid chromatography–tandem mass spectrometry is effective for analysis of ergosterol in fungal‐infected nails

Acquired Disorders of the Nails and Nail Unit

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