Clinical features and outcomes in kidney transplant recipients with renal cell carcinoma: a single-center study

Abstract

BackgroundPrevious studies have recommended a 2- to 5-year waiting time prior to kidney transplantation (KT) in patients with end-stage renal disease (ESRD) and symptomatic renal cell carcinoma (RCC) and no delay for incidental early-stage RCC. Data on Asian KT recipients are unavailable.MethodsThis is a Korean single-center retrospective study on 35 KT recipients with ESRD and RCC. Patients were classified into two groups: early KT (KT performed within 1 year after nephrectomy for RCC, including KT with simultaneous nephrectomy) and delayed KT (KT performed over than 1 year after nephrectomy for RCC). Patient survival, graft survival, and cancer recurrence were compared between both groups.ResultsThere were no statistically significant differences in patient survival (P = 0.388), graft survival (P = 0.317), or graft rejection rate (P = 0.207) between the early and delayed KT groups. Additionally, there were no differences in pathological characteristics or RCC stage other than cancer histology: acquired cystic disease-associated RCC (47.4%) was the most common RCC type in the early KT group, whereas clear cell type (62.5%) was the most common RCC type in the delayed KT group. No RCC recurrence was observed.ConclusionPatients with early-stage and asymptomatic RCC do not require a mandatory observational period prior to KT after curative nephrectomy.

Renal cell carcinoma of different pathological types in bilateral native kidneys of a kidney transplant recipient: A case report and literature review

“…In the case we present, the right kidney tumor was not detected at first by ultrasound. Therefore, computed tomography and/or magnetic resonance imaging are often needed as further confirmatory examinations, especially for patients with the renal cystic disease ( 25 ).…”

Urological malignancies in kidney transplant recipient patients

“…However, it has been advocated as RCC has been reported to be bilateral in 20% of ESRD patients. 17 Current pre-transplant screening recommendations for transplant candidates were typically not well validated. According to the European Renal Best Practice Transplantation Guidelines 18 , screening in ESRD patients is usually performed following the same protocols suggested for the general population.…”

Approach to kidney transplant patients with pre-transplant malignancy

“…The current guidelines for RCC also suggest that no delay is required for subjects with small or incidentally discovered RCC, while the recommendations for patients who have been treated for symptomatic RCC or for those with large or invasive tumors are conflicting. In this issue of Journal, Park et al [9] also reported that patients with early-stage and asymptomatic RCC did not require a mandatory observational period prior to kidney transplantation after curative nephrectomy.…”