Clinical Features and Prognosis Analysis of Hodgkin Lymphoma: A Multicenter Retrospective Study Over a Decade of Patients in China

Yu, Wenyan; Geng, Mei; Hao, Jie; Chen, Mei; Zhang, Sujiang; Wang, Jin; Mi, Jian-Qing

doi:10.1016/j.clml.2017.02.005

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…This is in line with an epidemiologic study by the WHO, which stated that Hodgkin lymphoma is more often found in men.1 This study also confirms the findings of Wen-Yan Yu, et al, who obtained a ratio of Hodgkin lymphoma incidence of 1.67:1 between men and women. 22 Statistical analysis indicated an insignificant correlation between microvessel density and gender (p=0.88), with a tendency for higher microvessel density in men compared to women. This is in line with Panico et al and Makboul et al, who stated that there is no statistically significant correlation between gender and microvessel density.…”

Section: Discussionmentioning

confidence: 92%

Correlation of Microvessel Density with Clinicothological Features of Hodgkin Lymphoma

Zulfikar¹,

Murti²,

Liberty³

et al. 2023

MPI

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BackgroundAngiogenesis is the process of new blood vessel growth that has an important role in tumor development. Microvessel density (MVD) assessment is one of the methods to assess angiogenesis. A high MVD is associated with a poor prognosis in various types of cancer including Hodgkin lymphoma (HL). Although, HL incidence is lower in developing countries, the death rate is higher in these regions. Moreover, this type of lymphoma is higher among young and reproductive people. The aim of this study was to determine the association between microvessel density and HL clinicopathological characteristics.MethodsThis was an observational analytic study with a cross-sectional method, conducted at the Anatomical Pathology Department/Dr. Mohammad Hoesin Palembang. The samples were paraffin blocks diagnosed as HL for period 2016-2021 and had complete clinicopathological data according to the criteria of this study. The slides were immunostained with antibody anti-CD34. One microvessel was determined by observing the endothelial morphology and CD34 expression in endothelial cytoplasm and/or cell membrane, then was evaluated and calculated by Image J. Data was statistically analyzed by STATA version 15.ResultsMajority HLs in this study were discovered in the age group of <45 years (71.00%), male (61.30%), nodal location (80.60%) and lymphocyte rich classical HL (LRCHL) subtype (51.60%). Although there was no significant association between MVD and the clinicopathological characteristics of HL, high MVD tend to occur in the age <45 years, male, nodal location, and LRCHL subtype.ConclusionThere was no significant association between microvessel density and HL clinicopathological characteristics.

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Section: Discussionmentioning

confidence: 92%

Correlation of Microvessel Density with Clinicothological Features of Hodgkin Lymphoma

Zulfikar¹,

Murti²,

Liberty³

et al. 2023

MPI

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“…However, the data from two Chinese cohorts did not reveal a comparable conclusion, where younger patients with HL did not necessarily have better FFP than elderly patients. 10,21 Diverse age distribution among different study cohorts could be one explanation for this data discrepancy. Approximately 20% of patients were aged ≥60 years in the current study.…”

Section: Discussionmentioning

confidence: 95%

Prognostic Factors for Clinical Outcomes in Patients with Newly Diagnosed Advanced-stage Hodgkin Lymphoma: A Nationwide Retrospective Study

et al. 2022

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Introduction While Hodgkin lymphoma (HL) is mostly curable, outcomes for advanced-stage HL remain unsatisfactory. The International Prognostic Score and its modifications were developed to predict HL prognosis; however, more straightforward prognostic factors are needed. This study aimed to identify simpler prognostic factors for advanced-stage newly diagnosed HL (NDHL). Methods This retrospective study used the Taiwan National Health Insurance Research Database and the Taiwan Cancer Registry. Patients with advanced-stage NDHL receiving ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) or ABVD-like regimens between 2009 and 2016 were enrolled. Cox proportional hazards models were used to identify prognostic factors for the time to next treatment (TTNT) and overall survival (OS). We used the time-dependent area under the receiver operating characteristic curve (AUROC) to evaluate model performance. Results The study included 459 patients with advanced-stage NDHL. A bimodal age distribution (peaks 20-44 and >65 years) was observed. Over a median follow-up of 4.7 years, the complete remission and OS rates were 52% and 76%, respectively. Age ≥60 years (adjusted hazard ratio [aHR]: 1.73, 95% confidence interval [CI]: 1.23-2.43), extranodal involvement (1.40, 1.05-1.87), B symptoms (1.53, 1.13-2.06), and Charlson Comorbidity Index (CCI) ≥1 (1.49, 1.08-2.06) were significantly associated with a shorter TTNT. The time-dependent AUROC was .65. With a time-dependent AUROC of .81, age ≥60 years (4.55, 2.90-7.15) and CCI ≥1 (1.86, 1.18-2.91) were risk factors for worse OS. Conclusion Older age and more comorbidities were risk factors for an inferior OS in advanced-stage NDHL, while older age, extranodal involvement, B-symptoms, and higher CCI were significantly associated with disease relapse.

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“…This sustained response and survival rates over the years underscore the e cacy of the standard treatment of ABVD for HL in the Saudi population, which is similar to Western and Eastern countries. 9,13,14,15,16,17 It is essential to continue monitoring and analyzing these trends as newer combination regimens, such as AAVD, emerge. 9 In our study, only a modest 6% of patients were treated with AAVD, making it challenging to derive meaningful insights regarding its correlation with response and survival rates.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Outcomes of Patients Newly Diagnosed with Hodgkin Lymphoma: A Multicenter Descriptive Cohort Study Hodgkin Lymphoma features and outcomes in Saudi Arabia

Alalawi,

Alrajhi,

Alshahrani

et al. 2024

Preprint

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Background Hodgkin Lymphoma (HL) is a prominent B-cell neoplasm, that impacts global and Saudi populations. Given limited large-scale studies focusing on HL in Saudi Arabia, this retrospective multicenter cohort study reviewed clinical outcomes and characteristics of Saudi HL patients. Methods All adult patients newly diagnosed with HL at three local tertiary care hospitals from January 2016 to December 2021 were included. Patients were excluded if they were diagnosed with nodular lymphocyte-predominant HL, known to have liver cirrhosis, or received unknown chemotherapy regimens. Patient demographics, comorbidities, HL type and stage, treatment, and clinical outcomes were collected. Results Out of 765 screened patients, 537 with classical Hodgkin lymphoma (cHL) were included. Most patients had nodular sclerosis histopathology (81.7%) and were in stage IV (44.6%). ABVD was the primary chemotherapy treatment for cHL patients (84.9%). The overall response rate was 90.1%, with 83.6% achieved complete remission. During 12-month follow-up, 94.9% of patients were alive. Post-initial chemotherapy, 9.5% of patients experienced bleomycin-induced pulmonary toxicity, and 23.5% were hospitalized within six months. Almost 18% of patients had relapsed/refractory HL. Conclusion This national comprehensive study provides insights into the clinical features and outcomes of Saudi HL patients. The predominance of the nodular sclerosis subtype and high response rates to ABVD chemotherapy align with global trends, emphasizing the effectiveness of standard treatments for HL in Saudi Arabia. Monitoring patients closely remains critical for managing side effects and enhancing patient outcomes.

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Clinical Features and Prognosis Analysis of Hodgkin Lymphoma: A Multicenter Retrospective Study Over a Decade of Patients in China

Cited by 7 publications

References 32 publications

Correlation of Microvessel Density with Clinicothological Features of Hodgkin Lymphoma

Correlation of Microvessel Density with Clinicothological Features of Hodgkin Lymphoma

Prognostic Factors for Clinical Outcomes in Patients with Newly Diagnosed Advanced-stage Hodgkin Lymphoma: A Nationwide Retrospective Study

Clinical Characteristics and Outcomes of Patients Newly Diagnosed with Hodgkin Lymphoma: A Multicenter Descriptive Cohort Study Hodgkin Lymphoma features and outcomes in Saudi Arabia

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