Clinical Features and Risk Factors Analysis of Bronchitis Obliterans Due to Refractory Mycoplasma Pneumoniae Pneumonia in Children: A Nomogram Prediction Model

Abstract

BackgroundEarly prediction of bronchitis obliterans (BO) is of great significance to the improvement of the long-term prognosis of children caused by refractory mycoplasma pneumoniae pneumonia (RMPP). This study aimed to establish a nomogram model to predict the risk of BO in children due to RMPP.MethodsA retrospective observation was conducted to study the clinical data of children with RMPP (1-14 years old) during acute infection. According to whether there is BO observed in the bronchoscope, children were divided into BO and the non-BO groups. The multivariate logistic regression model was used to construct the nomogram model.Results141 children with RMPP were finally included, of which 65 (46.0%) children with RMPP were complicated by BO. According to the multivariate logistic regression analysis, WBC count, ALB level, consolidation range exceeding 2/3 of lung lobes, timing of macrolides, glucocorticoids or fiber bronchoscopy and plastic bronchitis were independent influencing factors for the occurrence of BO and were incorporated into the nomogram. The area under the receiver operating characteristic curve (AUC-ROC) value of nomogram was 0.899 (95% confidence interval [CI]: 0.848~0.950). The Hosmer-Lemeshow test showed good calibration of the nomogram (p=0.692).Conclusion: A nomogram model found by seven risk factor was successfully constructed and can use to early prediction of children with BO due to RMPP.

Efficacy of Ambroxol Hydrochloride Combined with Amoxicillin Potassium Clavulanate Combination on Children with Bronchopneumonia and Its Impact on the Level of Inflammatory Factors

“…According to the results, children with bronchitis and pneumonia have a higher level of WBC and higher expression of inflammatory factors such as CRP, IL-6, and TNF-α. After the proper treatment, the four indicators have significantly decreased [16,17]. Moreover, the treatment with ambroxol hydrochloride combined with amoxicillin potassium clavulanate combination resulted in lower WBC and inflammatory factors as compared with amoxicillin potassium clavulanate combination, suggesting a prominent efficacy of ambroxol hydrochloride combined with amoxicillin potassium clavulanate combination in the treatment of bronchitis pneumonia in children.…”

Acetylcysteine and budesonide for the treatment of refractory Mycoplasma pneumoniae pneumonia in children: a clinical observation

“…In recent years, an increasing number of Mycoplasma pneumoniae pneumonia (MPP) cases that are resistant, severe, and even fatal have been reported [13]. The airway and lung lesions of some individuals with refractory MPP (RMPP) remain severe, even if the children's body temperature returns to normal after standard treatment.…”