Clinical features associated with an increased risk for alcohol use disorders among family members.

Abstract

This study evaluated the risk for alcohol use disorders (AUDs) among first-degree relatives depending on whether a specific family member (proband) had an AUD history. For probands with AUD histories, we also evaluated whether certain clinical features were associated with higher rates of AUDs in family members as a means for identifying markers that signify a more familial form of AUD. The proband sample was recruited from high schools in Western Oregon communities at Age 16 and followed longitudinally until Age 30. Structured psychiatric histories of 2,414 first-degree relatives of 732 probands were ascertained when the proband was Age 24. For the full sample, a significant association was observed between proband AUD history and the density (proportion) of first-degree relatives with AUD histories. Univariate analyses indicated that several clinical features among probands with AUD histories were significantly associated with AUD family density. In multivariate analyses, proband AUD episode recurrence and anxiety disorder history features emerged as trend-level or statistically significant unique predictors of AUD family density. One of these features, AUD episode recurrence, demonstrated a significant association with AUD family density once other forms of psychopathology among first-degree relatives were controlled. No evidence of gender moderation of effects was observed. Findings overall indicate that the familial risk for AUDs is related to probands' AUD history status and clinical features they exhibit. (PsycINFO Database Record

Deconstructing the heterogeneity of alcohol use disorder: lifetime comorbid non-alcohol substance use disorder as a distinct behavioral phenotype?

“…Of these, 490 (67%) families produced data on all first-degree relatives and 242 (33%) provided data on some members ( M = 62% of all first-degree relatives within families) but missing data on one or more members. As reported elsewhere (Farmer et al, 2018), no differences on proband AUD history status were observed as a function of missing family data although there were some demographic differences related to missingness in some comparisons. Overall, 2414 adult first-degree relatives (730 biological mothers, 719 biological fathers, 476 female siblings, 489 male siblings) contributed data to this research.…”

Differences in Sociodemographic and Alcohol‐Related Clinical Characteristics Between Treatment Seekers and Nontreatment Seekers and Their Role in Predicting Outcomes in the COMBINE Study for Alcohol Use Disorder

“…Furthermore, participants filled out a baseline DrInC-2R (Miller, 1995), a 40-item self-administered inventory that measures the adverse consequences of drinking, unconfounded with other dimensions-consumption patterns, help seeking, and dependence-by focusing on 5 areas: physical, interpersonal, intrapersonal, impulse control, and social responsibility. Additionally, the family (mother/father) history of alcohol problems was collected, as it has been shown to be an indicator of increased risk and severity of AUD (Farmer et al, 2018). Other alcohol-related clinical characteristics included in our analyses were the age of onset and duration of AD, as well as the total number of drinks, DPDD, HDD, and PDA in the 30 days prior to baseline.…”