Clinical features, diagnosis and therapeutic strategies in pediatric multiple sclerosis

Ochi, Hirofumi

doi:10.1111/cen3.12347

Cited by 7 publications

(7 citation statements)

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“…Certain studies have also registered the PP course in pediatric and adolescent patient population in about 3% of the cases [ 17 ]. A positive family history of MS existed in 9.3% of patients, while other studies reported results ranging from 6 to 8% [ 26 ], or most extremely from 2 to 19% [ 16 , 27 ]. In our PedMS group, 24.1% of patients had positive family history for other autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Monofocal onset of the disease in our study is consistent with other studies, which reported monofocal onset in 54% to 90% patients, usually after puberty [ 5 , 29 ]. However, a number of studies have reported multifocal onset of disease in 50 to 70% of the cases, and mostly before puberty [ 26 ]. The most common initial symptoms are similar to other studies [ 21 , 30 , 31 ], which also reported sensory deficits followed by loss of vision, motor deficit, lesions of the cerebellum and brainstem [ 5 , 9 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

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Characteristics of pediatric multiple sclerosis: A tertiary referral center study

Nikolić¹,

Ivančević²,

Zaletel

et al. 2020

PLoS ONE

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Objective The present study represents one of the largest series of pediatric multiple sclerosis (PedMS) in Western Balkan region. This is the first study aimed to evaluate the characteristics of PedMS in the Serbian population. Methods This retrospective study on 54 PedMS, aged 7–17 years, was performed at the Clinic of Neurology and Psychiatry for Children and Youth in Belgrade, Serbia, a tertiary center for the diagnosis and treatment of children with neurological and psychiatric diseases. Results Female to male ratio was 37 (68.5%): 17 (31.5%). Family history of MS was noted in 9.3% and autoimmune diseases in 24.1% patients. Co-occurring migraine was in 7,4%. Monofocal onset of disease was present in 77.8% patients. The most common initial symptoms were optic neuritis (37%), sensory disturbances (31.5%), motor deficit (24.1%), cerebellar (18.5%) and brainstem lesions (16.7%), pain (9.3%), acute disseminated encephalomyelitis like symptoms (1.9%), and hearing loss (3.7%). Visual evoked potentials were pathological in 75.9% of patients. Oligoclonal bands were positive in 68.5% of patients. Magnetic resonance imaging showed periventricular (94.4%), infratentorial (77.8%), juxtacortical and cortical changes (55.6%) and changes in the cervical spinal cord (33.3%). The median EDSS score was 2.0. Conclusion Our cohort significantly differs from the literature data regarding more frequent occurrence of optic neuritis, hearing loss as a first symptom, the relapsing-remitting course of the disease, higher proportion of early onset of disease, presence of co-occurring migraine and the frequent occurrence of epilepsy and other autoimmune diseases in the family.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Characteristics of pediatric multiple sclerosis: A tertiary referral center study

Nikolić¹,

Ivančević²,

Zaletel

et al. 2020

PLoS ONE

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“…Bersesuaian dengan yang ditemukan pada populasi dewasa, diagnosis MS pada populasi anak bertumpu pada ditemukannya lesi yang mengalami perluasan dalam ruang dan waktu (disseminated in time DIT and disseminated in space, DIS), serta juga bertumpu pada keberhasilan eksklusi sejumlah kondisi klinis lainnya yang menyerupai multipel sklerosis. 14 Pada laporan kasus ini, penulis menampilkan sebuah laporan kasus multipel sklerosis pada seorang anak perempuan berusia 13 tahun 7 bulan yang dirawat di bangsal anak RSUP Dr.M.Djamil Padang. Diagnosis multipel sklerosis pada pasien ini ditegakkan berdasarkan pada sejumlah penemuan manifestasi klinis yang ditunjang oleh pemeriksaan…”

Section: Pembahasanunclassified

Multipel Sklerosis pada Anak

Rizminardo¹,

Syarief²,

Lestari³

et al. 2018

JKA

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AbstrakMultipel sklerosis (MS) adalah suatu penyakit neurodegeneratif akibat proses demielinisasi kronik pada sistem saraf pusat yang disebabkan oleh peradangan autoimun. Penyakit ini umumnya mengenai kelompok pasien usia dewasa muda (antara 30 sampai 40 tahun) dengan prevalensi umum di seluruh dunia adalah 30 kasus per 100.000 populasi; dan hanya sekitar 2-5% penyakit ini terjadi pada usia kurang dari 18 tahun. Berbeda halnya dengan yang terjadi pada populasi dewasa, penyakit MS pada populasi anak memiliki sejumlah variasi manifestasi klinis demielinisasi atipikal yang menyebabkan pengenalan dan diagnosis MS pada pasien anak merupakan suatu proses yang rumit. Telah dilaporkan suatu laporan kasus pada seorang anak perempuan berusia 13 tahun 7 bulan dengan keluhan utama kejang yang disertai penurunan kesadaran, dimana kedua manifestasi klinis ini merupakan manifestasi klinis yang jarang ditemukan pada pasien multiple sklerosis. Diagnosis MS pada pasien ditegakkan setelah dilakukannya pemeriksaan MRI kepala. Pasien kemudian diterapi dengan menggunakan steroid intravena dan pada pengamatan selanjutnya ditemukan perbaikan klinis yang nyata. Kata kunci: Multiple sklerosis, anak. AbstractMultiple sclerosis (MS) is a neurodegenerative disease due to chronic demyelinating process in the central nervous system caused by autoimmune inflammation. MS generally affects groups of young adults ( age of 30 -40 years) with prevalence throughout the world is 30 cases per 100,000 population. Only about 2-5% cases occur in patient aged less than 18 years. Unlike the adult population, MS in the pediatric population has various clinical manifestations of atypical demyelinating which laed to complexity in order of recognition and diagnosis. We had been reported a case of a girl aged 13 years and 7 months with the chief complaint of seizures accompanied by decrease of consciousness, which were rare clinical manifestations in multiple sclerosis patients. Diagnosis of MS in our patients was established based on the result of brain MRI. The patient subsequently was treated with intravenous steroid and the routine follow up revealed obvious clinical improvement.

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“…Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system [1]. The term childhood MS is used in patients whose first clinical signs occur before 18 years of age [2]. The incidence of MS in children is rare, compared to MS in adulthood.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life of Children and Adolescents with Multiple Sclerosis—A Literature Review of the Quantitative Evidence

Mrosková

Klímová

Majerníková

et al. 2021

IJERPH

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Background: Multiple sclerosis (MS) is a chronic disease of the central nervous system that also develops in patients under 18 years of age. The disease negatively affects the quality of life (QoL) of children and adolescents. We conducted a literature review. The aim of the review was to identify the QoL of pediatric patients with MS and assess the factors determining their QoL. Methods: We analyzed studies published between 2000 and 2020 in PubMed, Scopus, Science Direct, Web of Science, and EBSCO databases. Results: In all, 17 studies were included in the review. The most common tool in assessing QoL was the generic module PedsQL. The range of mean/median global score of QoL was 53.8–81.7. The worst QoL was dominantly reported in the school and emotional spheres, on the contrary, the disease’s least determined area of QoL was the social and physical dimension. In particular, disability and fatigue were important predictors of QoL. Conclusions: MS negatively affects the school and emotional spheres in particular, so it is important to pay greater attention to these spheres of life of MS patients. As the review studies pay insufficient attention to the analysis of positive factors and their impact on the QoL of MS patients, research should integrate these phenomena. The use of MS-targeted tools in future research in the pediatric MS population is also appropriate.

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Clinical features, diagnosis and therapeutic strategies in pediatric multiple sclerosis

Cited by 7 publications

References 59 publications

Characteristics of pediatric multiple sclerosis: A tertiary referral center study

Characteristics of pediatric multiple sclerosis: A tertiary referral center study

Multipel Sklerosis pada Anak

Quality of Life of Children and Adolescents with Multiple Sclerosis—A Literature Review of the Quantitative Evidence

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