Clinical Features of 2019 Novel Coronavirus Pneumonia Presented Gastrointestinal Symptoms But Without Fever Onset

An, Ping; Chen, Hongbin; Jiang, Xiaoda; Su, Juan; Xiao, Yong; Ding, Yijuan; Ren, Haixia; Ji, Mengyao; Chen, Yifei; Chen, Wei; Lv, Xiaoguang; Shen, Lei; Chen, Ming-Kai; Li, Jiao; Yin, Anning; Kang, Jian; Liu, Shuzhong; Tan, Wei; Wu, Lianlian; Dong, Weiguo; Cao, Jun; Zhou, Zhongyin; Sheng, T. T.; Chen, Guozhong; Zhou, Jing; Yang, Yanning; Yu, Honggang

doi:10.2139/ssrn.3532530

Cited by 46 publications

(45 citation statements)

References 6 publications

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“…In a study of 74 cases of COVID-19 with GI symptoms, Jin et al [32] highlighted that 28% had no respiratory symptoms. Similarly, Ping et al [34] and Pan et al [35] have reported 9 and 7 cases with GI complaints without respiratory symptoms, respectively. In a larger study by Luo et al [36], 16% (183 of 1141) of patients presented with only GI symptoms.…”

Section: Reported Literaturementioning

confidence: 79%

Corona Virus Disease-19 pandemic: The gastroenterologists’ perspective

Dhar

Samanta

Kochhar

2020

Indian J Gastroenterol

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The world is witnessing a serious public health threat in the wake of the third corona virus pandemic, a novel corona virus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]). The Corona Virus Disease-19 (COVID-19) is not limited to the respiratory system but has widespread involvement including the gastrointestinal (GI) tract and liver, with evidence of prolonged fecal shedding and feco-oral transmission. This finding has stirred up a hornet's nest of not only a newer modality of the spread of the virus but also a risk of the unpredictable duration of the infective potential of the shedders. We reviewed the literature on fecal shedding and possible implications on prevention and surveillance strategies. The pandemic is changing the management of underlying chronic diseases such as inflammatory bowel disease (IBD) and other diseases. Moreover, for the gastroenterologist, doing endoscopic procedures in this COVID-19 era poses a high risk of contamination, as it is an aerosol-generating procedure. There is a daily influx of data on this disease, and multiple societies are coming up with various recommendations. We provide a comprehensive review of all the reported GI manifestations of COVID-19 infection and the side effects of confounding drugs. We have summarized the management recommendations for diseases such as IBD with COVID-19 and nutritional recommendations and provided a concise review of the endoscopy guidelines by the various societies. This review provides a comprehensive account and a lucid guide covering various aspects of gastroenterology practice during this COVID-19 pandemic.

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Section: Reported Literaturementioning

confidence: 79%

Corona Virus Disease-19 pandemic: The gastroenterologists’ perspective

Dhar

Samanta

Kochhar

2020

Indian J Gastroenterol

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“…A systematic review [17] explored the possibility of using lopinavir/ritonavir (LPV/r) to treat COVID-19, with the results supporting the use of LPV/r as a part of an experimental regimen for COVID-19 pneumonia treatment. Clinical features were reported in 21 studies [48][49][50][51][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77]. The main symptoms of patients with COVID-19 at onset were found to be fever and cough, with a reduced lymphocyte count, which is similar to previous beta coronavirus infections [78,79].…”

Section: Topicsmentioning

confidence: 87%

Coronavirus disease (COVID-19): a scoping review

et al. 2020

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Background In December 2019, a pneumonia caused by a novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and has rapidly spread around the world since then. Aim This study aims to understand the research gaps related to COVID-19 and propose recommendations for future research. Methods We undertook a scoping review of COVID-19, comprehensively searching databases and other sources to identify literature on COVID-19 between 1 December 2019 and 6 February 2020. We analysed the sources, publication date, type and topic of the retrieved articles/studies. Results We included 249 articles in this scoping review. More than half (59.0%) were conducted in China. Guidance/guidelines and consensuses statements (n = 56; 22.5%) were the most common. Most (n = 192; 77.1%) articles were published in peer-reviewed journals, 35 (14.1%) on preprint servers and 22 (8.8%) posted online. Ten genetic studies (4.0%) focused on the origin of SARS-CoV-2 while the topics of molecular studies varied. Nine of 22 epidemiological studies focused on estimating the basic reproduction number of COVID-19 infection (R0). Of all identified guidance/guidelines (n = 35), only ten fulfilled the strict principles of evidence-based practice. The number of articles published per day increased rapidly until the end of January. Conclusion The number of articles on COVID-19 steadily increased before 6 February 2020. However, they lack diversity and are almost non-existent in some study fields, such as clinical research. The findings suggest that evidence for the development of clinical practice guidelines and public health policies will be improved when more results from clinical research becomes available.

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“…8 Similarly, An et al reported 9 patients presenting only with digestive symptoms at the onset. 26 This underlines the fact that pure GI form of COVID-19 infection, although less common, can exist and confuse the clinical scenario. This can be a red flag sign for the gastroenterologist to ensure better self-protection from possible infection.…”

Section: Symptomatologymentioning

confidence: 99%

2019 Novel Coronavirus Infection: Gastrointestinal Manifestations

Samanta

Dhar

Kochhar

2020

Journal of Digestive Endoscopy

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The world is witnessing a major public health crisis in the wake of the third coronavirus strain pandemic, a novel coronavirus (severe acute respiratory syndrome coronavirus 2). Although initially thought to be a pure respiratory pathogen, recent reports have highlighted not only the extrapulmonary effects of the virus but also, importantly, the gastrointestinal tract (GIT) effects. Various studies have looked into the effects of this novel coronavirus infection (coronavirus-19 disease [COVID-19]) on GIT involvement with reports of more frequent involvement than previously expected. With feco-oral transmission, debate being conclusively proven with fecal samples testing positive for COVID-19 and longer shedding time, it only underlines the importance of GIT involvement. Moreover, the presence of other GI diseases, such as inflammatory bowel disease, with COVID-19 infection might wreak havoc leading to poor patient outcomes.

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Clinical Features of 2019 Novel Coronavirus Pneumonia Presented Gastrointestinal Symptoms But Without Fever Onset

Cited by 46 publications

References 6 publications

Corona Virus Disease-19 pandemic: The gastroenterologists’ perspective

Corona Virus Disease-19 pandemic: The gastroenterologists’ perspective

Coronavirus disease (COVID-19): a scoping review

2019 Novel Coronavirus Infection: Gastrointestinal Manifestations

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