Clinical Features of Bacteremia Caused by Methicillin-Resistant Staphylococcus aureus in a Tertiary Hospital

Yamada, Koichi; Yanagihara, Katsunori; Hara, Yukiko; Araki, Nobuko; Harada, Yousuke; Morinaga, Yoshitomo; Matsuda, Junichi; Izumikawa, Koichi; Seki, Masafumi; Kakeya, Hiroshi; Yamamoto, Yoshihiro; Kohno, Shigeru; Kamihira, Shimeru

doi:10.1620/tjem.224.61

Cited by 23 publications

(14 citation statements)

References 32 publications

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“…Lobo and colleagues (6) showed in their study that in a heterogeneous population group in an intensive care unit, the serum reference value of CRP correlated with an increased risk of multiple organ failure and death. In the study of Yamade and colleagues (7) the average reference value of leukocytes in sepsis patients was 11,12, while the number of leukocytes less than 4 was associated with an increased mortality, which has been proved by other studies, as well.…”

Section: Discussionmentioning

confidence: 71%

Staphylococcal Bacteraemia/Sepsis - Characteristics of Laboratory Parameters

Lukovac¹,

Pitic²,

Koluder³

et al. 2013

Med Arh

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The results have showed that even in the course ofa bacteraemia, there is a significant increase in the non-specific inflammatory parameters indicating the gravity ofbacteraemia as well, with a constant risk of developing sepsis and septic shock. The importance of running and following-up the laboratory parameters herewith is emphasised for the purpose of detecting sepsis in a timely manner and administering an adequate therapy.

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Section: Discussionmentioning

confidence: 71%

Staphylococcal Bacteraemia/Sepsis - Characteristics of Laboratory Parameters

Lukovac¹,

Pitic²,

Koluder³

et al. 2013

Med Arh

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“…Staphylococcus aureus or methicillin-resistant Staphylococcus aureus has been a leading cause of infections in both hospital and community settings, and bloodstream infection caused by MRSA was one of the most serious infections with high mortality [20]–[22]. In China, S. aureus was one of the leading pathogens isolated from bloodstream, and the average prevalence of MRSA among S. aureus BSI isolates reached up to 40% [10]–[11].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological and Genetic Diversity of Staphylococcus aureus Causing Bloodstream Infection in Shanghai, 2009-2011

Wang

Han

et al. 2013

PLoS ONE

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Objectives Staphylococcus aureus or methicillin-resistant Staphylococcus aureus (MRSA) has been an important pathogen causing bloodstream infections. Our study aimed to investigate the epidemiological and genetic diversity of clinical S. aureus isolates from patients with bloodstream infection in four hospitals of Shanghai from 2009 to 2011.MethodsA collection of S. aureus isolates causing bloodstream infection from four hospitals in the central part of Shanghai was carried out. Antimicrobial susceptibility testings of collected isolates were performed according to the Clinical and Laboratory Standards Institute (CLSI) guidelines, and spa-type, multi-locus sequence typing, agr type and toxin gene profiling were performed to explore the molecular diversity. Moreover, MRSA strains were also characterized by Staphylococcal cassette chromosome mec (SCCmec) typing.ResultsThe drugs such as linezolid, teicoplanin and vancomycin were efficacious for treating S. aureus including MRSA bloodstream infection. Methicillin-sensitive Staphylococcus aureus (MSSA) strains displayed distinct diversity in molecular characterization and toxin genes, and three virulent MSSA strains encoding at least five toxins were detected. Five community-associated MRSA (CA-MRSA) strains were found, but the majority (88.7%) of MRSA strains belonged to two epidemic clones (ST239-MRSA- III and ST5-MRSA- II) with different toxin gene profiles among patients with bloodstream infection.ConclusionsHealthcare-associated MRSA (HA-MRSA) strains were still the main pathogen causing bloodstream infections in spite of the emergence of CA-MRSA strains in hospital setting.

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“…Staphylococcus aureus is one of the most prevalent human pathogens, causing a broad variety of diseases ranging from mild skin and soft-tissue infections to infective endocarditis, osteomyelitis, bacteraemia and necrotizing pneumonia (Al-Talib et al, 2011;Dryden, 2009;Yamada et al, 2011). Since the first report of a drug-resistant S. aureus strain in 1961, these resilient bacteria have become a particular threat to human health.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and molecular characterization of Staphylococcus aureus recovered from different clinical specimens of inpatients at a teaching hospital in Shanghai between 2005 and 2010

Yan

et al. 2013

Journal of Medical Microbiology

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Staphylococcus aureus, including meticillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), is associated with severe nosocomial human infections. This study aimed to investigate the molecular profile, including the dynamic changes and genotype/phenotype correlation, of S. aureus isolates recovered from different clinical specimens of inpatients with S. aureus infection over a 6-year span at a teaching hospital in Shanghai, China. Between 2005 and 2010, a random sample of 610 unique S. aureus isolates was collected from different clinical samples of inpatients with S. aureus infection for molecular and antibiotic susceptibility analysis. The results showed that, among the 610 S. aureus isolates, 20 sequence types (STs) determined by multi-locus sequence typing (primarily ST239, ST5, ST7, ST188 and ST398) and 52 spa types (primarily t002, t037, t030 and t601) were found. In total, 444 isolates (72.8 %) were MRSA and 166 (27.2 %) were MSSA. ST239-MRSA-III-spa t037 and ST5-MRSA-II-spa t002 were the predominant MRSA clones. From 2005 to 2010, spa t002, spa t037 and their corresponding STs (ST5 and ST239) were the most frequent clones among all of the S. aureus isolates and showed the most resistant phenotypes to various antibiotics. Generally, the different genotypes showed different drug resistance rates, but no isolates were resistant to vancomycin, teicoplanin or linezolid. The profiles of virulence and resistance genes differed by genetic background, with the ST239 and ST5 strains showing higher resistance rates to gentamicin, cefoxitin, ampicillin, cefazolin, erythromycin, clindamycin and levofloxacin than strains of other types. Moreover, the antiseptic resistance genes qacA/B were generally associated with these two types. The prevalence of STs was different among different clinical specimens and also changed by year. Recently (2009Recently ( -2010, the distribution of predominant MRSA clones decreased, whilst the prevalence of non-predominant MSSA clones increased, especially for the isolates causing bacteraemia. Continual monitoring of clinical isolates is necessary to develop and maintain an effective strategy against S. aureus infection in the hospital setting.

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Clinical Features of Bacteremia Caused by Methicillin-Resistant Staphylococcus aureus in a Tertiary Hospital

Cited by 23 publications

References 32 publications

Staphylococcal Bacteraemia/Sepsis - Characteristics of Laboratory Parameters

Staphylococcal Bacteraemia/Sepsis - Characteristics of Laboratory Parameters

Epidemiological and Genetic Diversity of Staphylococcus aureus Causing Bloodstream Infection in Shanghai, 2009-2011

Phenotypic and molecular characterization of Staphylococcus aureus recovered from different clinical specimens of inpatients at a teaching hospital in Shanghai between 2005 and 2010

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