Epidemiological and Genetic Diversity of Staphylococcus aureus Causing Bloodstream Infection in Shanghai, 2009-2011

Xu, Chen; Wang, Wenkui; Han, Lizhong; Liu, Ying; Zhang, Hong; Tang, Jin; Li, Qingzhong; Huangfu, Yu-Chan; Ni, Yizhao

doi:10.1371/journal.pone.0072811

Cited by 31 publications

(40 citation statements)

References 24 publications

(36 reference statements)

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“…CC5 (S. aureus: 44/120, 36.7%; MRSA: 37/53, 69.8%) was the dominant clone among patients with SAB at Ruijin Hospital in Shanghai from 2013 to 2018 in this study, slightly different from our previous research conducted in Shanghai from 2009 to 2011 that CC8 (ST239) might be more common among patient with SAB before 27 . However, shifts may be occurring in the molecular epidemiology of S. aureus and MRSA among patients with bloodstream infections.…”

Section: Discussioncontrasting

confidence: 99%

Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus Causing Bloodstream Infections at Ruijin Hospital in Shanghai from 2013 to 2018

Xiao

et al. 2020

Sci Rep

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Staphylococcus aureus or methicillin-resistant Staphylococcus aureus (MRSA) is an important issue associated with significant morbidity and mortality and well known as a predominant pathogen causing bloodstream infection (BSis) globally. to estimate the antibiotic resistance and molecular characteristics of S. aureus causing BSIs in Shanghai, 120 S. aureus isolates (20 isolates each year) from the patients with S. aureus BSIs from 2013 to 2018 were randomly selected and enrolled in this study. Fifty-three (44.2%) MRSA isolates were determined, and no isolate was found resistant to vancomycin, daptomycin, synercid, linezolid and ceftaroline. The toxin genes tst, sec, seg and sei were found more frequently among MRSA isolates compared with MSSA isolates (all P < 0.0001). Twentynine sequence types (STs) were identified, and ST5 (23.3%) was the most common ST, followed by ST398 (11.7%) and ST764 (10.0%). SCCmec II (73.6%) was the most frequent SCCmec type among MRSA isolates. The dominant clonal complexes (CCs) were CC5 (ST5, ST764, ST965 and ST3066; 36.7%) and the livestock-associated clone CC398 (ST398, 11.7%). MRSA-CC5 was the predominant CC among MRSA isolates (37/53, 69.8%), and CC5-II MRSA was found in 34 isolates accounting for 91.9% (34/37) among CC5 MRSA isolates. In addition, all 29 tst-positive MRSA isolates were CC5-MRSA as well. Our study provided the properties and genotypes of S. aureus causing BSis at Ruijin Hospital in Shanghai from 2013 to 2018, and might suggest of value clues for the further study insights into pathogenic mechanisms intrinsically referring to the development of human-adapted S. aureus clones and their diffusions. Bloodstream infections (BSIs) is a severe infection with high incidence and lethality all over the world, and it always prolonged hospital stay for a long period 1. It has been reported to be one of the seven leading causes of death in North America and Europe 2. Staphylococcus aureus is well known as one of the most important human pathogens across the world and is capable of causing a variety of infections in healthcare facilities and communities. Furthermore, S. aureus is one of the major and most fatal causes of bacteremia with an estimated mortality of 20%, and at least 50% of patients with S. aureus bacteremia (SAB) will develop complicated bacteremia 3. S. aureus is one of the most common causes of severe BSIs with high morbidity and mortality. Early mortality associated with SAB appears to have plateaued at approximately 20-30% 4 , and imposes a substantial burden on patients and healthcare systems. In the United States, the annual incidence of SAB is 4.3 to 38.2 per 100,000 person-years, and the 30-day all-cause mortality of SAB is 20% and has not changed since the 1990s 5. In Ireland,

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Section: Discussioncontrasting

confidence: 99%

Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus Causing Bloodstream Infections at Ruijin Hospital in Shanghai from 2013 to 2018

Xiao

et al. 2020

Sci Rep

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“…In the current study, STs associated with both healthcare (ST239 and ST22) and community (ST80 and ST8) infections were found in MRSA strains that were epidemiologically defined as HA and CA. As reported in a previous study in China (Chen et al., ), majority of HA‐MRSA strains were belonged to the epidemic clones ST239. Consistently in this study, ST239 was the predominant lineage among HA‐MRSA strains (60%), whereas it was also detected among CA‐MRSA (26.1%) as was reported in a recent study carried out in China (Xie et al., ).…”

Section: Discussionsupporting

confidence: 70%

What is behind phylogenetic analysis of hospital‐, community‐ and livestock‐associated methicillin‐resistantStaphylococcus aureus?

El-Hamid

Bendary

Merwad

et al. 2019

Transbound Emerg Dis

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Summary Methicillin‐resistant Staphylococcus aureus (MRSA) has been shown to be the predominant life‐threatening pathogen in Egypt. MRSA is a major cause of severe healthcare‐associated (HA) infections. During the last decades, the incidence of community‐associated (CA) MRSA infections has a complex epidemiology arising from the circulation of different strains in the general population. Moreover, livestock‐associated (LA) MRSA emerged recently becomes an emerging threat to public health. Therefore, it is important to illuminate the differences between CA‐, HA‐ and LA‐MRSA to shed light on their genetic diversity and evolution. This study presents the first data on analysing the correlation between CA‐, LA‐ and HA‐MRSA using antibiogram typing, molecular characteristics and antimicrobial resistance and virulence genes’ profiles. Overall, HA‐MRSA strains tended to be multidrug resistant and less virulent than both LA‐ and CA‐MRSA strains. Importantly, CA‐MRSA strains had a high homology with each of HA‐ and LA‐MRSA. However, no similarity was observed between HA‐ and LA‐MRSA. Our findings suggest that the epidemiological changes in genetic behaviour between HA‐ and LA‐MRSA are due to the presence of CA‐MRSA confirming that CA‐MRSA has created a public health crisis worldwide.

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“…Different from our findings, some studies conducted in China and India had shown higher rates of MRSA isolates [7,8], whereas in Brazil the resistance rate has remained around 40% [1]. Comparing the results obtained with the susceptibility test for 14 antimicrobials from isolates from the two hospitals, it was possible to detect more MRSA isolates causing BSI in hospital 2 than in hospital 1.…”

contrasting

confidence: 99%

Vancomycin minimum inhibitory concentrations using different susceptibility methods in Staphylococcus aureus isolates

Sousa

Costa

Cavalcante

et al. 2014

J Infect Dev Ctries

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Epidemiological and Genetic Diversity of Staphylococcus aureus Causing Bloodstream Infection in Shanghai, 2009-2011

Cited by 31 publications

References 24 publications

Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus Causing Bloodstream Infections at Ruijin Hospital in Shanghai from 2013 to 2018

Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus Causing Bloodstream Infections at Ruijin Hospital in Shanghai from 2013 to 2018

What is behind phylogenetic analysis of hospital‐, community‐ and livestock‐associated methicillin‐resistantStaphylococcus aureus?

Vancomycin minimum inhibitory concentrations using different susceptibility methods in Staphylococcus aureus isolates

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