Clinical features of gastric duplications: evidence from primary case reports and published data

Abstract

Background Alimentary tract duplications are rare congenital lesions, and only 2–8% of them are located in the stomach. Gastric duplications (GD) can lead to severe adverse events. Thus, surgical resection is required once the disease is diagnosed. The main purpose of this study is to describe the clinical features of gastric duplications and to provide evidence for the diagnosis and treatment. Methods A retrospective review of eight gastric duplications at two medical centers Peking University People’s Hospital (PKUPH) and Shandong Provincial Hospital from 2010 to 2020 was conducted. Furthermore, the literature search was also conducted by retrieving data from PubMed, EMBASE and Cochrane Library databases from the date of the database inception to January 15, 2021. Results Eight patients who were diagnosed as gastric duplications and 311 published records were included in this study. In all, 319 patients were identified: Vomiting and abdominal pain were the most frequent clinical presentations among juveniles and adults respectively. There was no difference in gender distribution (F: 53.16% vs M: 46.84%), and the cystic gastric duplications were the most common type of the gastric duplications (87.04%). More than half (53.30%) of included cases were located in the greater curvature of stomach. Conclusions Gastric duplications could present with a wide spectrum of symptomatology, which might be misdiagnosed easily as other diseases. For cystic gastric duplications, the optimal treatment was a complete surgical removal. But conservative treatment might be an alternative strategy for tubular gastric duplications.

Uncommon Presentation of Gastric Duplication Cyst with Left-Sided Portal Hypertension: A Case Report and Literature Review

“…The treatment of GDCs remains debatable, as there are multiple methods that can be followed depending on the size of the cyst and the patient's symptoms. While some authors advocate for conservative treatment, others promote surgery as a safe method to reduce the risk of malignancy [1,32,33]. Jai P. Singh et al described two cases: the first was diagnosed using CT and exploratory laparotomy, while the second was diagnosed through EUS, which provided higher accuracy in diagnosis.…”

“…At the moment, in the literature, there are two types of gastric duplication cysts: one type lacks communication with the gastric cavity or the tubular digestive tract, while the other type does communicate with the gastric lumen. When symptomatic, this type of pathology can cause a wider range of symptoms, such as persistent abdominal pain, nausea and vomiting or even life-threatening hematemesis [1][2][3][4][5].…”

“…Due to the frequently common symptoms with other pathologies and the imaging peculiarities of GDCs, diagnosing them is often challenging and can be mistaken. Thus, only 35% of patients had a preoperative diagnosis of GDC, confirming the significance and the niche in which this pathology exists [1]. GDCs can lead to obstruction, torsion, hemorrhage or rare cases of left-sided portal hypertension or malignancy, which have a poor prognosis, so a proper diagnostic is important [14,15].…”

Delayed Presenting Gastric Duplication Cyst Mimicking a Left Adrenal Cyst in a Young Female: A Case Report with a Literature Review

“…Some authors reported a female predominance with a ratio of 8:1, while others observed a male predilection [12, 14]. In another study, Li et al [5] found equal gender distribution.…”

“…Based on age and lesion features, GDC can be associated with abdominal pain, hematemesis, vomiting, and weight loss. Although it may be asymptomatic in adults and pose challenges for preoperative diagnosis [5], GDC is often misdiagnosed with several diseases, like gastrointestinal stromal tumors and other gastric and endocrine tumors [1,6]. Its association with ectopic tissues of gastrointestinal organs or mimicking other anomalies, such as lymphangiomas, has also been reported [4,6].…”