Clinical features of ileal pouch‐anal anastomosis in African American patients with underlying ulcerative colitis

Abstract

SUMMARY Background

Systematic review: outcomes and post‐operative complications following colectomy for ulcerative colitis

“…Twelve of the 28 studies included reported specific reasons for patients receiving the procedures. Medically refractory UC was the most common indication for receiving surgical procedures; of those studies reporting indications, seven of the 12 (58%) reported that the majority of patients enrolled had received surgery due to medically refractory UC . Three of the 12 studies (25%) reported that the majority of enrolled patients had received surgery due to acute episodes of UC (e.g.…”

“…More than half of the 28 studies included were conducted in the USA ( n = 17) with the remaining studies being conducted worldwide, including Japan ( n = 4) and Denmark ( n = 2) …”

“…Four studies analysing 946 patients with UC reported pouchitis in a long‐term follow‐up (>30 days post‐operatively). The frequency of pouchitis ranged from 1/12 (8%) to 237/576 (41%) . None of the included studies reported pouchitis as an early complication.…”

“…Two studies analysing 239 patients with UC, one prospective and one retrospective, reported severe pouch problems as a long‐term outcome, with a frequency in a range of 0 (0%) to 2/12 (17%) . Severe pouch problems lead to outcomes described as any of pouch loss, pouch excision or pouch failure.…”

Review article: the pathogenesis of pouchitis

“…122 A study of African Americans and Caucasians found no differences in chronic pouchitis incidence. 123 However, the number of studies examining the relationship between ethnicity and pouchitis are limited and the genetic predisposition to this disease is largely unresolved.…”