Clinical Features of Lupus Cystitis Complicated with Hydroureteronephrosis in a Chinese Population: Table 1.

Zhang, Guojuan; Li, Hang; Huang, Wen; Li, Xuemei; Li, Xuewang

doi:10.3899/jrheum.100617

Cited by 17 publications

(45 citation statements)

References 16 publications

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“…Common causes of urinary manifestations in SLE patients include infection and neurogenic bladder secondary to transverse myelitis, and this would lead to urinary tract obstruction . However, occurrence of hydronephrosis has been occasionally associated with bladder and/or GI tract involvement of SLE . In the present study, a total of 15 patients with SLE‐associated hydronephrosis, not attributed to infection, stones, neuropathy or tumor, were identified, and a significant proportion (80.0%) was associated with GI involvement, followed by urinary bladder manifestations (33.3%).…”

Section: Discussionmentioning

confidence: 58%

“…Prolonged, significant obstruction of the urinary tract can lead to deterioration in renal function, which may require urological intervention, such as ureteral catherization . Development of hydronephrosis is occasionally reported in patients with SLE involvement of the urinary system and/or GI tract, and is possibly associated with edema and inflammation of the ureterovesical junction . However, there are very few studies regarding management and clinical outcomes of hydronephrosis in SLE patients.…”

Section: Introductionmentioning

confidence: 99%

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Clinical outcomes of hydronephrosis in patients with systemic lupus erythematosus

et al. 2015

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Clinical outcomes of hydronephrosis in patients with systemic lupus erythematosus

et al. 2015

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“…Histologically, widespread submucosal edema or chronic cystitis with perivascular infiltration of mononuclear cells are the pathologic finding in bladder biopsies . Cystoscopy may reveal stellate scars and mucosal ulcers . In this case, the diagnosis of lupus cystitis is made very unlikely given that the patient does not meet diagnostic criteria for SLE .…”

Section: Differential Diagnosismentioning

confidence: 97%

“…Lupus cystitis is characterized by urinary frequency and inflammation of the bladder with a normal urinalysis . Typical symptoms include suprapubic pain, dysuria, urinary urgency, and nocturia . Nishizake et al have described a positive anti‐dsDNA antibody in 76.1% of lupus cystitis cases .…”

Section: Differential Diagnosismentioning

confidence: 99%

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A 53‐Year‐Old Man With Dysuria, Pyuria, and Genital Ulcers

Jimenez

Psutka

Stone

et al. 2016

Arthritis Care & Research

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A 53-year-old man with dysuria, pyuria, and genital ulcers. History of the present illnessThe patient developed dysuria and pain at the base of the penis 1 month before presenting to an outside hospital. His pain worsened and he developed fever, pyuria, and penile ulcers a couple of days prior to admission. The patient also noted light pink urine, which was concerning for hematuria. He was treated empirically for both chlamydia and herpes simplex virus (HSV) infections with doxycycline and acyclovir, respectively, but urine polymerase chain reaction assays for Chlamydia trachomatis and Neisseria gonorrhea were negative and a penile ulcer swab was negative for HSV. His diagnosis was amended to prostatitis and he was discharged on levofloxacin. Amoxicillin was added after his urine culture grew a group B Streptococcus species.He followed up in the urology clinic as an outpatient and underwent a transrectal ultrasound of the prostate, the results of which were not consistent with prostatitis. A computed tomographic scan of the pelvis with contrast demonstrated mild thickening of the bladder wall and perivesical stranding consistent with inflammation. He continued to have painful urination and pyuria, for which he was readmitted to the hospital 3 weeks later.During his second hospital admission, he underwent repeat cystoscopy that revealed a large necrotic mass at the bladder trigone. The mass obstructed both ureteral orifices. Transurethral resection of the trigonal mass was performed, with bilateral ureteral stent placement. Histologic examination of the surgical specimen was notable for acute suppurative inflammation and necrosis, without evidence of malignancy.Ulcerative lesions on the glans penis persisted. These were retested for HSV as well as for Lymphogranuloma venereum and Treponema pallidum, but all of these assays were negative. He was prescribed a topical glucocorticoid, which seemed to decrease the size of the ulcers.During his admission, his serum creatinine rose from baseline of 1.2 to 4.0 mg/dl. His acute kidney injury was attributed to the combination of contrast-induced renal injury and obstructive uropathy from his resected trigonal mass. His creatinine improved but did not normalize following placement of ureteral stents. He developed a fever to 1018F and was started on piperacillin and tazobactam with no clear genitourinary source of infection. An extensive serologic evaluation demonstrated that the patient was negative for rheumatoid factor, antinuclear antibodies (ANAs), cyroglobulins, human immunodeficiency virus infection, hepatitis A, B, and C, and anti-neutrophil cytoplasmic antibodies (ANCA). The serum angiotensinconverting enzyme concentration was normal. Cultures of his penile lesion grew few yeast, but were otherwise unremarkable. The patient was then transferred for further evaluation.The patient was admitted to the urology service with diagnoses of obstructive uropathy by a bladder mass of unknown etiology, pelvic pain, and penile ulcers. Examination of the urine sediment revealed n...

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Successful treatment of refractory cystitis associated with systemic lupus erythematosus with Belimumab

Song

Dai

et al. 2021

International Immunopharmacology

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Clinical Features of Lupus Cystitis Complicated with Hydroureteronephrosis in a Chinese Population: Table 1.

Abstract: Lupus cystitis may not be so rare as has been thought. The diagnosis of lupus cystitis should be considered when patients with SLE present with GI symptoms, and therapy should begin as early as possible.

Cited by 17 publications

References 16 publications

Clinical outcomes of hydronephrosis in patients with systemic lupus erythematosus

Clinical outcomes of hydronephrosis in patients with systemic lupus erythematosus

A 53‐Year‐Old Man With Dysuria, Pyuria, and Genital Ulcers

Successful treatment of refractory cystitis associated with systemic lupus erythematosus with Belimumab

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