Clinical features of new‐onset systemic lupus erythematosus in pregnant patients

Abstract

New-onset pregnant SLE patients were characterized with blood system involvement and generally experienced more adverse maternal outcomes than active patients with SLE history. However, adverse fetal outcomes in new-onset patients were the same as those of active patients with an SLE history.

Risk factors associated with adverse pregnancy outcomes in patients with new-onset systemic lupus erythematosus during pregnancy

“…Thus, SLE onset during pregnancy is more likely to result in pregnancy loss. This is consistent with the results of Zhao et al 21 and Zhang et al 22 regarding the effect of new-onset SLE during pregnancy. New-onset SLE during the first trimester of pregnancy greatly increased the risk of pregnancy loss, which consistent with the effect of SLE recurrence during pregnancy.…”

“…21 and Zhang et al. 22 regarding the effect of new-onset SLE during pregnancy. New-onset SLE during the first trimester of pregnancy greatly increased the risk of pregnancy loss, which consistent with the effect of SLE recurrence during pregnancy.…”

The Influence of Pregnancy on the Clinical Evolution and Prognosis of Pre-Existing Inflammatory and Autoimmune Skin Disorders and Their Management

“…In addition, transient neonatal lupus due to passive transfer of maternal autoantibodies (especially with positive anti Ro/La antibodies) may occur, and rarely causes permanent and potentially fatal cardiac damage (heart block), peaking at 16-26 weeks of gestation [108,109,114,116]. New-onset pregnant SLE patients are generally considered to experience more adverse maternal outcomes than active patients with SLE history [117]. Unlike women with systemic disease, those with exclusive mucocutaneous involvement have outcomes similar to those of healthy controls [118].…”

Caracterización de mujeres embarazadas con lupus eritematoso sistémico y resultados materno-fetales en el noroeste de Colombia. Estudio descriptivo

“…desenlaces adversos, tanto maternos como fetales (21)(22)(23) . De esta cohorte se destaca que fueron comunes los desenlaces adversos obstétricos en las pacientes con anticuerpos antifosfolípidos positivos (10) y que fue más frecuente la presencia de los trastornos hipertensivos asociados al embarazo, así como los desenlaces adversos en los pacientes con antecedente de nefritis (5,9,21,24) . Hasta donde se sabe, este es el primer estudio que provee información local sobre el tema.…”

“…Respecto al compromiso renal, un tercio de las gestantes tenía nefritis al ingreso y, un 16 % desarrolló un compromiso renal durante la gestación. También se observó una mayor frecuencia de los trastornos hipertensivos asociados al embarazo, a pesar de que los valores de creatinina permanecieron estables en más del 90 % de las pacientes, esto es acorde a lo reportado en estudios previos (21,28) y resalta el papel de la nefritis en los desenlaces obstétricos, no solo por la actividad misma sino por el daño renal crónico y sus consecuencias.…”