No abstract

GC therapy of 1 mg/kg for ITP patients during pregnancy is less efficiency than non-pregnant population and increases the incidence of hypertensive disorders. The use of lower starting doses of prednisone may be suggested for use in pregnancy.

Thrombocytopenia in SLE during pregnancy indicates higher disease activity, severe organ damage, early onset preeclampsia and higher pregnancy loss.

New-onset pregnant SLE patients were characterized with blood system involvement and generally experienced more adverse maternal outcomes than active patients with SLE history. However, adverse fetal outcomes in new-onset patients were the same as those of active patients with an SLE history.

Objective: To evaluate the outcomes of cervical spondylotic radiculopathy secondary to bony foraminal stenosis treated with anterior cervical discectomy and fusion (ACDF) combined with anterior cervical foraminotomy (ACF) assisted by High-Definition 3-Dimensional Exoscope. Methods:In this retrospective study, a total of 19 consecutive patients (12 males and seven females, with an average of 49.2 years, range from 40 to 59 years) with spondylotic radiculopathy caused by bony foraminal stenosis underwent ACDF combined with ACF assisted by High-Definition 3-Dimensional Exoscope in our hospital between January 2019 and December 2019 were included in this study. All patients signed the consent form before the surgery. The patient baseline information such as gender, age, body mass index (BMI), surgery time, blood loss, hospital stay, lesion segment, side, follow-up time and postoperative complications were recorded. The Japanese Orthopedic Association (JOA), Neck Disability Index (NDI), and Visual Analogue Scale (VAS) were measured and compared before surgery, 1 months and final follow-up after surgery. The radiographic outcomes were evaluated using the C 2 -C 7 angel, disc height, foraminal height, superior diagonal distance, inferior diagonal distance, and foraminal area. Results:The involved levels included C 4 -C 5 (six cases), C 5 -C 6 (10 cases), C 6 -C 7 (three cases). The mean duration of the surgery, mean blood loss, mean hospital stay, and mean follow-up were 100 AE 11.10 min, 19.4 AE 7.05 mL, 7.1 AE 0.99 days, and 12.1 AE 2.25 months, respectively. The average preoperative JOA score was 11.9 AE 1.31, then improved to 15.7 AE 0.73 (t = À13.45, P < 0.001) and 16.2 AE 0.74 (t = À14.39, P < 0.001) at 1 month after operation and at last follow-up, respectively. The average preoperative NDI score was 27.3 AE 3.36, then decreased to 5.1 AE 1.79 (t = 20.63, P < 0.001) and 4.5 AE 1.21 (t = 25.53, P < 0.001) 1 month after operation and at last followup, respectively. The average preoperative VAS score was 6.7 AE 0.93, then decreased to 2.4 AE 0.69 (t = 15.05, P < 0.001) and 1.9 AE 0.78 (t = 16.40, P < 0.001) 1 month after operation and at last follow-up, respectively. As compared with the condition before surgery, there was a significant improvement in the C 2 -C 7 angel, disc height, foraminal height, and foraminal area (P < 0.05). None of the patients developed postoperative vascular injury, nerve injury, loosening and rupture of the internal fixation, displacement of interbody fusion cage, and pseudarthrosis. Conclusion:ACDF combined with ACF assisted by High-Definition 3-Dimensional Exoscope is effective and safe for the treatment of CSR caused by secondary to bony foraminal stenosis.