Clinical features of pachyvessels associated with polypoidal choroidal vasculopathy in chronic central serous chorioretinopathy

Wang, Te-An; Chan, Wei-Chun; Tsai, Shih‐Wei; Chen, Lee-Jen

doi:10.1038/s41598-021-93476-2

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…Our results showed that IL-4 was significantly associated with the choroidal thickness and the presence of polypoidal lesions in eyes with PNV. This is consistent with reports that showed that the development of polypoidal lesions was closely associated with development of pachyvessels 47 . Collectively, the PNV diseases appeared to be associated with vascular remodeling including the development of polypoidal lesions.…”

Section: Discussionsupporting

confidence: 93%

Association of IL-4 with pachychoroid neovasculopathy

Baba

Koyama

Uotani

et al. 2023

Sci Rep

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The purpose of this study was to identify the inflammatory cytokines that were associated with pachychoroid neovasculopathy (PNV). Seventy-five eyes of 75 patients with PNV, 145 eyes of 145 patients with neovascular age-related macular degeneration without pachyvessels, and 150 eyes of 150 normal subjects were examined for the levels of intraocular cytokines. In eyes with PNV, the levels of IL-1α, IL-1β, IL-2, IL-4, IL-10, and VEGF were significantly higher than that of the controls. Logistic regression analysis showed that the highest association with the pachyvessels was found for IL-4, IL-2, and IL-1α. In eyes with PNV, the levels of IL-4, IL-2, IL-5, IL-13, IL-1α, and IL-1β were significantly higher in eyes with both increased choroidal thickness and choroidal vessel diameter. The strongest correlation with the choroidal thickness and vessel diameter was observed for IL-4. In PNV eyes with polypoidal lesions, the levels of IL-4, IL-17, and TNFβ were significantly correlated with the number of polypoidal lesions. Of these cytokines, IL-4 was especially associated with the thickness of the choroidal vessels and the formation of polypoidal lesions. We conclude that IL-4 is most likely involved in establishing the clinical characteristics of PNV and polypoidal vascular remodeling.

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Section: Discussionsupporting

confidence: 93%

Association of IL-4 with pachychoroid neovasculopathy

Baba

Koyama

Uotani

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…This is consistent with previous reports that showed that the development of polypoidal lesions was closely associated with development of pachyvessels. 44 Collectively, the PNV diseases appear to be associated with a vascular remodeling including the development of polypoidal lesions. In addition, the pachyvessels may also promote choroidal neovascularization.…”

Section: Discussionmentioning

confidence: 99%

Association of IL-4 with pachychoroid neovasculopathy

Baba

Koyama

Uotani

et al. 2022

Preprint

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The purpose of this study was to identify inflammatory cytokines that are associated with pachychoroid neovasculopathy (PNV). Seventy-five eyes of 75 patients with PNV, 145 eyes of 145 patients with neovascular age-related macular degeneration without pachyvessels, and 150 eyes of 150 normal subjects were examined for the levels of intracameral cytokines. In eyes with PNV, IL-1α, IL-1β, IL-2, IL-4, IL-10, and VEGF were significantly elevated compared to controls. Logistic regression analysis indicated highest association with pachyvessels was observed for IL-4, IL-2, and IL-1α. In eyes with PNV, IL-4, TNFα, IL-17, IL-2, IL-12, IL-15, IL-5, IL-13, IL-1α, and IL-1β significantly increased choroidal thickness. Highest correlation with choroidal thickness was observed for IL-4. In PNV eyes with polypoidal lesions, the level of IL-4, IL-17, and TNFβ significantly correlated with the number of polypoidal lesions. We determined how the different disease characteristics of PNV were associated with the elevated cytokines. Of all these cytokines, IL-4 contributed significantly to the thickening of the choroidal vessels and to the formation of polypoidal lesions. We conclude that IL-4 is most likely involved in the establishing the clinical characteristics of PNV and polypoidal vascular remodeling. This may help to establish future therapeutic strategy for PNV.

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