Clinical Features of Pulmonary Embolism

Barritt, D W; Jordan, S.C.

doi:10.1016/s0140-6736(61)92891-4

Cited by 54 publications

(20 citation statements)

References 8 publications

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“…Venous thromboembolism consists of PTE and DVT. Although PTE is a life-threatening disease, the survival rate can be improved with appropriate treatment [1][2][3][4][5]. For this reason, the precise diagnosis of DVT (the cause of PTE) is important for planning treatment.…”

Section: Discussionmentioning

confidence: 99%

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Experimental venous thrombi: MRI characteristics with histopathological correlation

Ichiki¹,

Sakai²,

Nango³

et al. 2012

BJR

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Objectives: The purpose of this study was to evaluate the MRI characteristics of venous thrombus over set time thresholds with histopathological correlation in a porcine model. Methods: Inferior vena cava thrombi were induced in 12 pigs. MRI was performed in three pigs 2 h, 1 day, 3 days and 2 weeks after thrombus induction. Results: The MRI characteristics were analysed in correlation with histopathological findings. The thrombi after 2 hours, which consisted of red blood cells (RBCs), showed isointensity on T 1 weighted images (T 1 WIs) and hyperintensity on both T 2 weighted images (T 2 WIs) and diffusion-weighted images (DWIs . After 2 weeks, the thrombi, which revealed RBC lysis surrounded by granulation tissues, showed isointensity on T 1 WIs and hyperintensity on T 2 WIs and DWIs. The mean ADC value was 2.48610 23 mm 2 s 21. Conclusion:The temporal MRI characteristics seemed to be related to chemical and physical changes in RBC and organisation of granulation tissues. Free radicals generated by macrophages might also be related to some extent.

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Section: Discussionmentioning

confidence: 99%

“…The ADC values in these two pigs were 1 . Macroscopically, the thrombi were dark red in colour, and microscopically they consisted of red blood cells (RBCs).…”

Section: H After Thrombus Inductionmentioning

confidence: 91%

Experimental venous thrombi: MRI characteristics with histopathological correlation

Ichiki¹,

Sakai²,

Nango³

et al. 2012

BJR

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“…The association of OC and VTE was first reported by Jordan in 1961 [55] and the increased risk of thrombosis was primarily associated with the estrogen content of the OC. This prompted a steady decline of the EE content from more than 100 µg to less than 20 µg daily.…”

Section: Changes In Hemostasis With Ocmentioning

confidence: 96%

Thrombophilia and Female Sex Hormones

Tóth¹,

Rogenhofer²,

Budiman³

et al. 2006

CWHR

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Female sexual steroids strongly influence different steps of coagulation. This explains why women's health during different life spans is affected significantly by thrombophilias. The aim of this review article is to summarize current knowledge on thrombophilias regarding oral contraception (OC) and hormonal replacement therapy (HRT).More than a hundred million women worldwide use female sexual steroids as OC or HRT. The understanding of acquired and inherited thrombophilias has increased dramatically over the last two decades.At present, it is not recommended that all OC or HRT users should be routinely screened for acquired or inherited thrombophilias. The usefulness of testing for these disorders in the presence of multiple thrombotic risk factors should be considered on an individual basis.

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“…3 According to data in Europe and the United States, the mortality rate of acute PTE is as high as 30% when it is not diagnosed and treated promptly, but decreases to 2 to 8% when appropriate treatment is performed. 11, 12 It is known that early diagnosis and appropriate treatment decrease the mortality rate substantially. Independent determinants of mortality of acute PTE include right ventricular dysfunction on echocardiography, advanced age (≥70 years), cancer, congestive heart failure, chronic obstructive pulmonary disease, hypotension, and tachypnea.…”

Section: Jcs Guidelines For Pulmonary Thromboembolism and Dvtmentioning

confidence: 99%