Clinical features of renal tubular dysplasia, a new hereditary disease in Japanese Black cattle

ABSTRACT. To evaluate the energy condition of cattle with growth retardation, propionate (PTT) and arginine tolerance tests (ATT) were carried out. The insulin/glucagon concentration ratio immediately before PTT or ATT in the cattle with growth retardation was lower than in the control. In the growth-retarded cattle, insulin-AUC 0-120min during PTT was lower than in the control, while glucagon-AUC 0-120min was the same as in the control. Insulin-AUC 0-120min during ATT in the cattle with growth retardation tended to be lower than in the control, whereas glucagon-AUC 0-120min was the same. Therefore, insulin-AUC 0-120min /glucagon-AUC 0-120min in the cattle with growth retardation was lower than in the control during both tolerance tests. The growth-retarded cattle showed lower insulin/glucagon ratio similar to that found in starved and lactating cattle, a suggesting lack of energy. KEY WORDS: arginine tolerance test, growth-retarded cattle, propionate tolerance test.

mentioning

confidence: 99%

Insulin and Glucagon Secretory Patterns during Propionate and Arginine Tolerance Tests in Japanese Black Cattle with Growth Retardation

Takasu

Kishima

Nishii

et al. 2007

“…It is also known as "renal tubular dysplasia in Japanese Black cattle" [13][14][15][16][17] or "bovine chronic interstitial nephritis with diffuse zonal fibrosis" [5,8]. This disease is caused by a homozygous deletion of gene and is transmitted by autosomal recessive inheritance [8,14].…”

mentioning

confidence: 99%

“…In bovines, although studies of the CL-16 defect in the genetic field have developed considerably [5,8,[13][14][15][16][17][18], pathology of the defect remains to be elucidated. The purpose of this study was to clarify the histopathological characteristics of the CL-16 defect and conditions that lead to renal failure, and to examine the distribution of CL-16 protein immunohistochemically.…”

mentioning

confidence: 99%

Abnormal Development of Nephrons in <i>Claudin-16</i>- Defective Japanese Black Cattle

Okada

Ishikawa

Fujimori

et al. 2005

ABSTRACT. The kidneys of 37 Japanese Black calves aged 2 to 65 months diagnosed with Claudin 16 (CL-16) defect by the DNA-based test were examined pathologically. The animals exhibited clinical symptoms such as growth impairment, renal failure, overgrowth of hooves, and anemia at a young age. There was no correlation between the time of onset and age. Kidney weights relative to body weight were similar to those in normal animals, but both kidney net weights and size were reduced due to atrophy in animals that showed severe renal dysfunction. Histopathological examination of the kidneys showed reduction in the number of glomeruli, compensatory hypertrophy of glomeruli and tubules, and glomerular and tubular atrophy accompanied by interstitial fibrosis and lymphocytic infiltration. Glomeruli were clearly less in number in the kidneys of CL-16-defective animals than those of normal animals even in the cases with mild lesions. A small number of immature glomeruli and tubules were also detected, suggesting that there were fewer nephrons developed at birth in CL-16 -defective animals. It was suggested that a defect of the CL-16 gene is involved in the "abnormal development of nephrons". Immunohistopathological examination of the kidneys showed that the epithelium of thick ascending limb of Henle was stained with anti-CL-16 antibody in the control animals, but not in the affected animals, suggesting a defect of CL-16 in the epithelium of renal tubules in the affected animals. KEY WORDS: abnormal development, Claudin 16, Japanese Black cattle, nephrons, Paracellin-1.

“…Additionally, hereditary diseases involved in growth retardation, such as renal tubular dysplasia (RTD) [16] and red blood cell-band 3 deficiency [6], are also known to afflict Japanese black cattle. However, more detailed knowledge of the causes for insufficient growth of cattle has yet to be obtained.…”

mentioning

confidence: 99%

Endocrine Patterns in Two Strains of Japanese Black Cattle with Growth Retardation

Takasu

Hagiwara

Ohba

et al. 2005

ABSTRACT. Endocrine patterns were compared in 2 strains of Japanese black cattle with growth retardation; MHO-and HSK-paternal strains (MHO and HSK cattle, respectively). MHO cattle (n=8) displayed lower serum concentrations of insulin-like growth factor-1 (IGF-1), triiodothyronine (T3), thyroxine (T4), and cortisol (31.1 ± 20.7 ng/ml, 73.9 ± 51.9 ng/dl, and 2.9 ± 2.9 µg/dl, 1.3 ± 0.7 µg/dl, respectively) than those in both HSK cattle (n=5) (64.9 ± 47.6 ng/ml, 97.8 ± 40.7 ng/dl, 4.1 ± 2.1 µg/dl and 1.8 ± 1.1 µg/dl, respectively), and the controls (n=6) (314.7 ± 197.2 ng/ml, 140.2 ± 21.3 ng/dl, 5.8 ± 1.7 µg/dl, and 3.0 ± 1.4 µg/dl, respectively). The area under the concentration curve of growth hormone (GH-AUC 0-600 min) in MHO cattle (22210 ± 18951 ng•min/ml) tended to be greater than those in HSK (7887 ± 6340 ng•min/ml) and the controls (2811 ± 1275 ng•min/ml). MHO cattle showed a high GH-AUC 0-600 min in contrast to a low serum IGF-1 concentration, as well as lower serum T3, T4, and cortisol concentrations. HSK cattle exhibited the same secretory patterns, but much more moderately. Growth retardation in Japanese black cattle exhibits some variations based on pedigree. KEY WORDS: endocrine pattern, growth retardation, Japanese black cattle.