Endocrine Patterns in Two Strains of Japanese Black Cattle with Growth Retardation

Abstract

ABSTRACT. Endocrine patterns were compared in 2 strains of Japanese black cattle with growth retardation; MHO-and HSK-paternal strains (MHO and HSK cattle, respectively). MHO cattle (n=8) displayed lower serum concentrations of insulin-like growth factor-1 (IGF-1), triiodothyronine (T3), thyroxine (T4), and cortisol (31.1 ± 20.7 ng/ml, 73.9 ± 51.9 ng/dl, and 2.9 ± 2.9 µg/dl, 1.3 ± 0.7 µg/dl, respectively) than those in both HSK cattle (n=5) (64.9 ± 47.6 ng/ml, 97.8 ± 40.7 ng/dl, 4.1 ± 2.1 µg/dl and 1.8 ± 1.1 µg/dl, respectively), and the controls (n=6) (314.7 ± 197.2 ng/ml, 140.2 ± 21.3 ng/dl, 5.8 ± 1.7 µg/dl, and 3.0 ± 1.4 µg/dl, respectively). The area under the concentration curve of growth hormone (GH-AUC 0-600 min) in MHO cattle (22210 ± 18951 ng•min/ml) tended to be greater than those in HSK (7887 ± 6340 ng•min/ml) and the controls (2811 ± 1275 ng•min/ml). MHO cattle showed a high GH-AUC 0-600 min in contrast to a low serum IGF-1 concentration, as well as lower serum T3, T4, and cortisol concentrations. HSK cattle exhibited the same secretory patterns, but much more moderately. Growth retardation in Japanese black cattle exhibits some variations based on pedigree. KEY WORDS: endocrine pattern, growth retardation, Japanese black cattle.

Alterations of Growth, Blood Biochemical Components and Hormone Profiles by Intensified Nutrition in Growth Retarded Japanese Black Cattle

“…Increased nutritional supply increases the serum IGF-1 concentration, and then it decreases serum GH [3,4,6]. Regarding the former reports of GH and IGF-1 in growth retarded JB cattle [9,19,20,22] and retarded Brahman cattle [5], the serum GH concentra- tions and amplitude of GH pulses increased with low concentrations of serum IGF-1. Our study showed similar results during the Pre period in addition to low concentrations of serum Alb, TC and T4 and plasma glucose.…”

“…However, many cattle with normal appetite and activities are also categorized as growth retarded [7-10, 13, 19-22, 24, 27]. Kitagawa et al [8,9] and Takasu et al [19][20][21][22]24] investigated JB cattle with retarded growth and suggested that they had an abnormal IGF-1-GH axis that exhibits higher GH and lower IGF-1 concentrations. These retarded cattle also had abnormalities of energy and protein metabolism that were verified by their blood profiles.…”

“…These retarded cattle also had abnormalities of energy and protein metabolism that were verified by their blood profiles. In addition, the possible involvement of hereditary abnormalities has also been suggested [9,13,19]. Thus, retarded growth cattle with a normal appetite might arise from various factors.…”

Insulin and Glucagon Secretory Patterns during Propionate and Arginine Tolerance Tests in Japanese Black Cattle with Growth Retardation

“…Thus, the cattle with growth retardation might be in the negative energy condition compared with the control, and their assimilability was suggested to be lower than the control. Since primary endocrine disorders such as hypothyroidism and growth hormone deficiency were eliminated as causes of growth retardation in Japanese black cattle [14], this lower assimilability might be the cause of the growth retardation and possibly associated with their abnormalities in fermentation, digestibility, absorption, and/or energy metabolism. Thus, it is necessary to investigate these functions for determining the cause of growth retardation.…”

Carrier Rate of Factor XI Deficiency in Stunted Japanese Black Cattle

“…It has been suggested that neonatal weak calf syndrome is associated with asiderotic anemia and immunodeficiency [16], and that hypogenesis syndrome is associated with growth hormone (GH) deficiency [17], insulin like growth factor-1 (IGF-1) deficiency in contrast with hypersecretion of GH [5,6,11,26], primary or secondary underactive thyroid function [5,6,24,30] and other factors.…”