Clinical Features, Prognosis, Diagnostic Approaches and Treatment of Multiple Primary Malignancies in the Digestive System

Ikubo, Akashi; Matsufuji, Shohei; Morifuji, Yoshihiro; Koga, Hiroki; Kobarai, Tomonari; Kouya, Naohiko; Sakai, Masashi; Samejima, Ryuichirou; Kojima, Katsuo; Tabuchi, Masanobu; Yunotani, Seiji

doi:10.21873/anticanres.13904

Cited by 8 publications

(8 citation statements)

References 14 publications

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“…Surgery and adjuvant therapy may be the most common to perform [9]. While prognosis is poorer, it may be largely dependent on the stage of the involved cancers [10][11][12].…”

Section: Case Presentationmentioning

confidence: 99%

Complete Response of High Microsatellite Instability Gastric Cancer and Synchronous Microsatellite Stability Rectal Cancer

Hunzeker¹,

Bhakta²,

Gudipally³

et al. 2022

Cureus

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Gastric cancer, a leading cause of cancer-related death in the world, may occur with an additional synchronous malignancy in rare cases. Of these rare cases many are colorectal cancer. Microsatellite instability is a phenomenon that may contribute to the pathogenesis of both cancers, as are field cancerization and genetic susceptibility, although none of these explain many concurrent cases. In this case, we described a patient with locally advanced microsatellite instability-high gastric cancer and synchronous microsatellite stable rectal cancer, who received a combination chemo-immunotherapy regimen and achieved complete response. This report reflects on current knowledge surrounding synchronous primary malignancies and achieving complete response.

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“…Surgery and adjuvant therapy may be the most common to perform [9]. While prognosis is poorer, it may be largely dependent on the stage of the involved cancers [10][11][12].…”

Section: Case Presentationmentioning

confidence: 99%

Complete Response of High Microsatellite Instability Gastric Cancer and Synchronous Microsatellite Stability Rectal Cancer

Hunzeker¹,

Bhakta²,

Gudipally³

et al. 2022

Cureus

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“…Multiple primary malignant tumors (MPMTs) are defined as malignant tumors with two or more different histological features in the same individual at the same or different times, excluding metastasis or recurrence (1). The development of MPMTs is associated with genetic predisposition, potential immune deficiencies, history of chemoradiotherapy, and exposure to carcinogens (2,3).The development of diagnostic and improved treatments for cancer contributes to an increase in the number of cancer survivors and makes it possible for cancer patients to live long enough to develop a second primary tumor (4)(5)(6)(7).The second primary carcinoma is an important prognostic factor among patients who survive a prior cancer, and is estimated to be the sixth most common malignant tumor worldwide (8).Cancer survivors account for 3.5% of the total population in the United States, and approximately 10% of newly diagnosed malignant tumors develop in cancer survivors (9).…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and survival of second primary breast carcinoma with extramammary malignancies

2023

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ObjectivesTo investigate the characteristics, diagnosis, survival and prognosis of second primary breast carcinoma (SPBC).Materials and methodsRecords of 123 patients with SPBC in Tianjin Medical University Cancer Institute & Hospital between December 2002 and December 2020 were retrospectively reviewed. Clinical characteristics, imaging features and survival were analyzed and comparisons between SPBC and breast metastases (BM) were made.ResultsOf 67156 newly diagnosed breast cancer patients, 123 patients (0.18%) suffered previous extramammary primary malignancies. Of the 123 patients with SPBC, approximately 98.37%(121/123)were female. The median age was 55 years old (27-87). The average diameter of breast mass was 2.7 cm (0.5-10.7). Approximately 77.24% (95/123) of the patients presented with symptoms. The most common types of extramammary primary malignancies were thyroid, gynecological cancers, lung, and colorectal. Patients with the first primary malignant tumor of lung cancer were more likely to develop synchronous SPBC, and those with the first primary malignant tumor of ovarian cancer were more likely to develop metachronous SPBC. When comparing with BM, patients with SPBC were more often older (≥45 years old), at earlier stages (I/II), more microcalcification and less multiple breast masses in imaging. More than half (55.88%) of patients in the metachronous group developed primary breast cancer within 5 years after diagnosis of extramammary primary cancer. The median overall survival time was 71 months. Within 90 months, the prognosis of patients with synchronous SPBC was worse than that of patients with metachronous SPBC (p=0.014). Patients with BM had the worst outcome compared with patients with synchronous SPBC and metachronous SPBC (p<0.001).ER/PR-negative status, an interval of less than 6 months between the onset of two tumors, a late stage of first primary malignancy, and an age of diagnosis of first primary malignancy greater than 60 years predicted a worse prognosis for patients with SPBC.ConclusionThe possibility of SPBC should be considered during the follow-up of patients with primary extramammary malignancy, especially within 5 years of the onset of the first tumor. The stage of first primary malignancy and the age at diagnosis of first primary malignancy have an impact on the prognosis of patients with SPBC.

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“…Reports of multiple tumors, especially primary malignancies in the digestive system, have recently increased partly because of improved diagnostic techniques and the increasingly aging population. 1 However, reports of multiple synchronous benign tumors are relatively rare. To the best of our knowledge, we report the first case of gastric schwannoma (GS) coexisting with tubular adenoma of the gallbladder (GB).…”

Section: Introductionmentioning

confidence: 99%

Gastric schwannoma coexisting with tubular adenoma of the gallbladder: a rare combination

et al. 2023

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We report a case of a man in his early 50 s who was admitted to our hospital for anorexia. An imaging examination led to a preoperative diagnosis of a gastrointestinal stromal tumor and gallbladder stones. He underwent treatment by laparoscopic cholecystectomy and distal partial gastrectomy with lymph node dissection. The final histopathological diagnosis was gastric schwannoma and tubular adenoma of the gallbladder. Gastric schwannoma accounts for only 0.2% of all gastric tumors, and tubular adenoma constitutes only 2.2% of gallbladder tumors. This report describes the diagnosis and treatment process for this combination of tumors, thus providing a reference for similar cases.

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Clinical Features, Prognosis, Diagnostic Approaches and Treatment of Multiple Primary Malignancies in the Digestive System

Cited by 8 publications

References 14 publications

Complete Response of High Microsatellite Instability Gastric Cancer and Synchronous Microsatellite Stability Rectal Cancer

Complete Response of High Microsatellite Instability Gastric Cancer and Synchronous Microsatellite Stability Rectal Cancer

Clinical characteristics and survival of second primary breast carcinoma with extramammary malignancies

Gastric schwannoma coexisting with tubular adenoma of the gallbladder: a rare combination

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