Clinical guidelines for endoscopic diagnosis and monitoring of Crohn’s disease in children (Draft)

Budkina, T.N.; Лохматов, М. М.; Tupylenko, A.V.; Oldakovsky, V. I.; Korolev, G.A.; Yablokova, E.A.; Хавкин, А.И.

doi:10.31146/1682-8658-ecg-209-1-87-97

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…В настоящее время ни один из предложенных малоинвазивных методов не смог приблизиться по достоверности к эндоскопическим и морфологическим характеристикам. В связи с тем, течение болезни Крона у детей очень вариабельно и требует регулярного контроля, особенно при решении вопроса смены терапевтической тактики, оценка активности должна проводится неинвазивными методами на регулярной основе [6].…”

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The role of serum bilirubin in the pathogenesis of Crohn’s disease in children and assessment of its activity

Fedulova,

Vagin,

Khavkin

2024

ECG

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Introduction. The article is devoted to the identification of a marker of imbalance of oxidative stress and the antioxidant system in children with Crohn’s disease. The putative level of total bilirubin as an integrative method for assessing Crohn’s disease activity is highly correlated with indicators of oxidative stress and the antioxidant system (ischemia, modifying albumin, malondialdehyde, catalase, sulfhydryl groups and glutathione). Purpose: to explain the relationship between the level of total bilirubin and the activity of the inflammatory process in Crohn’s disease, which allows the introduction of the studied integrative indicator in clinical practice. Materials and methods. Based on the results of scientific studies of biomarkers of oxidative stress (albumin-modifying ischemia - plasma IMA, malondialdehyde - plasma MDA) and the antioxidant system (plasma SH-groups, catalase and reduced erythrocyte glutathione), as well as a simultaneous study of the level of total bilirubin in children diagnosed with Crohn’s disease. To search for a differential method for assessing the level of Crohn’s disease activity by the degree of bilirubin, use binary logistic regression. Results and survey. The results of the study showed a clear relationship between the increase in bilirubin levels and the severity of oxidative stress. It has been established that with a decrease in the level of total bilirubin, there is a predominance of oxidative stress over the antioxidant system, which leads to an increase in inflammation activity. It has been proven that the level of total bilirubin can be used in the complex activity of diseases as a minimally invasive, as well as an objective and acute marker. The sensitivity and specific sensitivity of this protocol is 90.9% and 93.3% respectively, which allows the use of total bilirubin as a marker of inflammation in Crohn’s disease.

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Section: Introductionunclassified

The role of serum bilirubin in the pathogenesis of Crohn’s disease in children and assessment of its activity

Fedulova,

Vagin,

Khavkin

2024

ECG

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Inflammatory Bowel Diseases in Children: Modern Achievements in Diagnostics and Therapy

Khavkin,

Nalyotov,

Marchenko

2023

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Aim: to highlight current trends in the diagnosis and treatment of inflammatory bowel diseases in children.Key points. The incidence of inflammatory bowel disease among children has increased significantly over the past three decades. Moreover, these diseases are often characterized by a severe course. At the same time, strategies for diagnosing and treating these patients are being improved: doctors began using high-definition endoscopy and video capsule endoscopy, the determination of fecal calprotectin, biological therapy (infliximab, adalimumab, vedolizumab, and ustekinumab) and drug monitoring. Particular attention is paid to the role of dietary recommendations.Conclusion. Currently, there has been significant progress in the diagnosis and treatment of inflammatory bowel diseases in children.

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The diagnosis and surgery of small intestine duplication in 11-years girl

Shcherbakova,

Habibullina,

Lokhmatov

et al. 2024

RPJ

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There is presented the clinical report of the diagnosis and surgical treatment of such rare malformation as tubular duplication of the small intestine in an 11-years girl. Clinical manifestations were intense abdominal pain and intestinal bleeding of unknown origin. Video capsule enteroscopy (VCE) made it possible to identify the pathological area and determine its location. The article presents modern ideas about duplication of the small intestine. There are indicated diagnostic methods and signs to allow suspecting this malformation. The possibilities and criteria for VCE in diagnosing subepithelial lesions and identifying the source of intestinal bleeding are described.

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Clinical guidelines for endoscopic diagnosis and monitoring of Crohn’s disease in children (Draft)

Cited by 3 publications

References 33 publications

The role of serum bilirubin in the pathogenesis of Crohn’s disease in children and assessment of its activity

The role of serum bilirubin in the pathogenesis of Crohn’s disease in children and assessment of its activity

Inflammatory Bowel Diseases in Children: Modern Achievements in Diagnostics and Therapy

The diagnosis and surgery of small intestine duplication in 11-years girl

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