Clinical, hematologic, hemostatic, and serum biochemical findings related to survival in Arabian horses with colic

Nikvand, Ali Abbas; Jalali, Seyedeh Missagh; Mashhadi, Alireza Ghadrdan; Jalali, Mohammad Hossein Razi; Amirabadi, Soroush Hassanpour

doi:10.1111/vcp.12779

“…12 Diagnostic procedures and pathophysiological mechanisms were studied in-depth to investigate coagulation disorders in horses. 13 In addition to identifying the history of the disease and performing a physical examination, evaluation of the hematological profile and blood chemistry of a horse can be done to trace the cause of the disease. The results of the examination can localize the cause of the disease based on the liver and spleen function.…”

Section: Introductionmentioning

confidence: 99%

“…12 Diagnostic procedures and pathophysiological mechanisms were studied in-depth to investigate coagulation disorders in horses. 13 …”

Section: Introductionmentioning

confidence: 99%

Risk factors, hematological and biochemical profile associated with colic in Delman horses in Gresik, Indonesia

Purnama

¹

,

Hendrawan²,

Wicaksono³

et al. 2022

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Background: Horses are herd animals that have been domesticated in the last century. In several countries, an overview of risk factors and clinical evaluation in horses with colic has not been well‐described. This study aimed to evaluate risk factors and hematological profiles in horses associated with colic in Gresik, East Java, Indonesia. Methods: A cross-sectional study was performed during April - October 2019. A total of 115 horses were diagnosed based on physical examination, clinical symptoms, and rectal examination. A questionnaire was asked to the horse-owners to analyze the risk factors while the clinical examination was performed and blood samples were collected for pre-treatment and 14 days post-treatment. Hematological profile was evaluated from a whole blood sample. Serum cortisol, plasma epinephrine, and norepinephrine concentrations were also evaluated after separating the aliquots. Results: Of the 115 horses, 96 were diagnosed with colic. The horses with colic showed a significant association between cases with gender (p<0.021), breed (p<0.000), wheat bran feeding (p<0.015), concentrate feeding (p<0.003), anthelmintics administration (p<0.000), gastrointestinal parasites (p<0.000), dental diseases (p<0.024), previous exposure to colic (p<0.000), body condition score (p<0.000), and access to water per day (p<0.000). Based on whole blood and serum evaluation, there were ameliorated significantly on the hematological profile (p<0.01), serum cortisol (p<0.05), and plasma epinephrine (p<0.01) at 14 days post-treatment. Conclusion: This study has identified factors associated with colic in Delman horses. The study provides crucial information to investigate cases of colic and to contribute the development of healthcare strategies during treatment and clinical evaluation.

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“…Plasma d-dimer has been examined in horses with diseases predisposing for concurrent hemostatic imbalances. In particular, horses with gastrointestinal (GI) disease and a strong systemic inflammatory response may develop hemostatic aberrations [ 15 , 16 , 18 ]. D-dimer measurements at admission and during hospitalization can be used to monitor the improvement in medical and surgical colic patients [ 16 ], and function as a prognostic marker of survival [ 15 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Investigation of two different human d-dimer assays in the horse

Honoré

¹

,

Pihl

²

,

Busk-Anderson

³

et al. 2022

BMC Vet Res

0

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Background D-dimer has value as a marker of thrombosis in critically ill horses and can provide additional information about prognosis. However, there are currently no equine species-specific d-dimer assays available, nor has there been any formal investigation of the applicability of human d-dimer assays in horses, so it is unknown, which assay performs best in this species. The aim of this study was therefore to evaluate and compare two human d-dimer assays for their applicability in horses. The study included four groups of horses: clinically healthy horses, horses with gastrointestinal (GI) disease and mild systemic inflammation based on low serum amyloid A (SAA) (low SAA group), horses with GI disease and strong systemic inflammation based on high SAA (high SAA group) and, horses with thrombotic GI disease caused by Strongylus vulgaris (also called non-strangulating intestinal infarction (NSII)) (NSII group). The assays evaluated were the STAGO STA-Liatest D-di + (Stago) and NycoCard™ D-dimer (NycoCard). Intra- and inter-coefficients of variation (CV) were assessed on two d-dimer concentrations, and linearity under dilution was evaluated. A group comparison was performed for both assays across the four groups of horses. A Spaghetti plot, Spearman Correlation, Passing Bablok regression and Bland–Altman plot were used to compare methods in terms of agreement. Results Ten horses were included in the clinically healthy group, eight in the low SAA group, eight in the high SAA group, and seven in the NSII group. For the Stago assay, intra- and inter-CVs were below the accepted level except for one inter-CV. The NycoCard assay did not meet the accepted level for any of the CVs. The linearity under dilution was acceptable for both the Stago and NycoCard. In the group comparison, both methods detected a significantly higher d-dimer concentration in the high SAA and NSII groups compared to the clinically healthy group. Method agreement showed slightly higher d-dimer concentrations with NycoCard compared to Stago. The overall agreement was stronger for the lower d-dimer concentrations. Conclusion Both the Stago and the NycoCard were found to be applicable for use in horses but were not directly comparable.

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“…11 Diagnostic procedures and pathophysiological mechanisms were studied in-depth to investigate coagulation disorders in horses. 12 In addition to identifying the history of the disease and performing a physical examination, evaluation of the hematological profile and blood chemistry of a horse can be done to trace the cause of the disease. The results of the examination can localize the cause of the disease based on the liver and spleen function.…”

Section: Introductionmentioning

confidence: 99%

Risk factors and hematological profile associated with colic in Delman horses in Gresik, Indonesia

Purnama

¹

,

Hendrawan²,

Wicaksono³

et al. 2021

View full text Add to dashboard Cite

Background: Horses are herd animals that have been domesticated in the last century. In several countries, an overview of risk factors and clinical evaluation in horses with colic has not been well‐described. This study aimed to evaluate risk factors and hematological profiles in horses associated with colic in Gresik, East Java, Indonesia. Methods: A cross-sectional study was performed during April - October 2019. A total of 115 horses were diagnosed based on physical examination, clinical symptoms, and rectal examination. A questionnaire was asked to the horse-owners to analyze the risk factors while the clinical examination was performed and blood samples were collected for pre-treatment and 14 days post-treatment. Hematological profile was evaluated from a whole blood sample. Serum cortisol, plasma epinephrine, and norepinephrine concentrations were also evaluated after separating the aliquots. Results: Of the 115 horses, 96 were diagnosed with colic. The horses with colic showed a significant association between cases with gender (p<0.021), breed (p<0.000), wheat bran feeding (p<0.015), concentrate feeding (p<0.003), anthelmintics administration (p<0.000), gastrointestinal parasites (p<0.000), dental diseases (p<0.024), previous exposure to colic (p<0.000), body condition score (p<0.000), and access to water per day (p<0.000). Based on whole blood and serum evaluation, there were ameliorated significantly on the hematological profile (p<0.01), serum cortisol (p<0.05), and plasma epinephrine (p<0.01) at 14 days post-treatment. Conclusion: This study has identified factors associated with colic in Delman horses. The study provides crucial information to investigate cases of colic and to contribute the development of healthcare strategies during treatment and clinical evaluation.

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Clinical, hematologic, hemostatic, and serum biochemical findings related to survival in Arabian horses with colic

Cited by 9 publications

References 34 publications

Risk factors, hematological and biochemical profile associated with colic in Delman horses in Gresik, Indonesia

Risk factors, hematological and biochemical profile associated with colic in Delman horses in Gresik, Indonesia

Investigation of two different human d-dimer assays in the horse

Risk factors and hematological profile associated with colic in Delman horses in Gresik, Indonesia

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