Blood Substitutes 2006
DOI: 10.1016/b978-012759760-7/50023-8
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Clinical Hemodilution

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Cited by 3 publications
(3 citation statements)
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“…At the time of the studies, PFC-augmented ANH was considered as rather safe [6,8]. However, the efficacy of mild ANH has been questioned [9], whilst deep ANH exposes the patient to low Hb levels that may not be well tolerated by some patients [10]. Hemodilution during cardiopulmonary bypass was since reported to cause neurologic injury in rats [11].…”
Section: An Inconclusive Clinical Trialmentioning
confidence: 99%
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“…At the time of the studies, PFC-augmented ANH was considered as rather safe [6,8]. However, the efficacy of mild ANH has been questioned [9], whilst deep ANH exposes the patient to low Hb levels that may not be well tolerated by some patients [10]. Hemodilution during cardiopulmonary bypass was since reported to cause neurologic injury in rats [11].…”
Section: An Inconclusive Clinical Trialmentioning
confidence: 99%
“…The clinical data signpost the combined ANH and excessive and rapid IAD as an inappropriate procedure. The procedure was subsequently discouraged for patients with coronary or pulmonary disease [10]. No evidence was found that linked the imbalance in side effects to the emulsion.…”
Section: An Inconclusive Clinical Trialmentioning
confidence: 99%
“…This can affect drugs with high protein binding, especially phenytoin and valproic acid. Reduction of gastric motility,33 increase of plasma volume34 and increase of renal blood flow35 are other mechanisms in which serum concentrations of AEDs can be altered during pregnancy.…”
Section: How Can Pregnancy Alter Aed Levels In Blood?mentioning
confidence: 99%