Clinical, Hormonal, and Metabolic Parameters in Women with Subclinical Hypothyroidism and Polycystic Ovary Syndrome: A Cross-Sectional Study

Abdel-Rahman, Mohamed; Tan, Justin; AbdelHafez, F.; Abdelkareem, Amr O; Henry, Drisana; Lisonkova, Sarka; Hurd, William W.; Liu, James H.

doi:10.1089/jwh.2017.6584

Cited by 25 publications

(23 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…19 In one of the other studies which was conducted at China shown to be association of hypothyroidism with PCOS with 32% and other studies shown association 24% to 21%. [20][21][22] The incidence reported in present study is comparable to all these studies. In the various studies conducted, has almost same incidence as that of present study since the age group of study are matching.…”

Section: Correlation Of Hypothyroidism With Polycystic Ovarian Syndromesupporting

confidence: 86%

Occurrence of hypothyroidism and its correlation with reproductive health problems: a cross sectional study

Kumar

Kotur

2019

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Thyroid dysfunction is 10 times more common in women than in men. Hypothyroidism among women of reproductive age group is linked to menstrual irregularities, polycystic ovarian syndrome (PCOS), miscarriage and infertility. Several studies are available in the literature reporting regarding impact of hypothyroidism on one or the other isolated problems of reproductive health problems.Methods: This cross-sectional study is conducted including 290 participants having various reproductive health problems attending the gynaecology OPD of a rural based tertiary care hospital of Tamil Nadu during the year 2017-2018.These participants were investigated for thyroid dysfunction and its correlation of hypothyroidism with reproductive health problems viz. menstrual irregularities, Polycystic ovarian diseases (PCOS), infertility and pregnancy loss was studied.Results: It was observed that 80.6% of the 290 participants were euthyroid and 16.97% were hypothyroid, who presented with menstrual irregularities like menorrhagia (28.6%), oligomenorrhea (20.8%), amenorrhoea (21.3%), PCOS (28.6%), infertility (21.6%) and 23.8% hypothyroid women had pregnancy losses of varying number.Conclusions: In present study the occurrence of hypothyroidism was found to be 16.89%. Since hypothyroidism has close association with problems like menstrual irregularities, PCOS, miscarriages and infertility, thyroid function test should be routinely recommended for these women. Thyroid dysfunction can be corrected with simple, cost-effective treatment. This will help in improvement in pregnancy outcome and also avoid subjecting women for major surgeries for menorrhagia.

show abstract

Section: Correlation Of Hypothyroidism With Polycystic Ovarian Syndromesupporting

confidence: 86%

Occurrence of hypothyroidism and its correlation with reproductive health problems: a cross sectional study

Kumar

Kotur

2019

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…The majority of studies used the Rotterdam criteria for PCOS diagnosis and only one study used the ESHRE/ASRM criteria. Subjects included in the meta-analysis were from five different countries including Spain ( 17 ), India ( 22 ), Italy ( 20 , 23 ), Brazil ( 21 ), and China ( 24 ), while those only included in systematic review were from America ( 25 ), India ( 26 ), China ( 27 ), Brazil ( 16 ), and Iran ( 28 ). Definition for SCH varied among studies, with TSH cut-off values ranging from 2.5 to 5 mIU/L.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, there was no difference in the mean values of all endocrine and metabolic parameters tested in the presence or absence of SCH with PCOS. However, abnormal FPG levels and insulin resistance were more likely in women who had SCH than in women without SCH independently of age and BMI ( 25 ). What is critical is that SCH is associated with insulin resistance ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Subclinical Hypothyroidism in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

et al. 2018

View full text Add to dashboard Cite

Background: The association between subclinical hypothyroidism (SCH) and polycystic ovary syndrome (PCOS) has been reported in several studies, but it is not well-recognized. The aim of this study was to evaluate the prevalence of SCH in women with PCOS.Methods: An extensive literature search was conducted in PubMed, Embase, Web of Science, and Cochrane Library databases. All articles published before May 2018 was considered for eligibility. No language restrictions were implemented. The prevalence of SCH in PCOS was calculated by the meta-analysis to produce an odds ratio (OR) with 95% confidence interval (CI).Results: A total of 6 studies including 692 PCOS patients and 540 controls were eligible for the meta-analysis. The combined odds ratio (OR) of SCH risk for women with PCOS compared with controls was 2.87 (95% CI = 1.82–9.92; P < 0.000001). The OR increased to 3.59 when limiting thyroid stimulating hormone (TSH) cut-off to ≥4 mIU/L.Conclusions: Women with PCOS are more likely to develop SCH.

show abstract

“…It is caused by follicular dysplasia, insulin resistance (IR), and hyperandrogenism, which is characterized by irregular menstruation, infertility, obesity, and hyperandrogenemia (3,4). PCOS patients often experience metabolic disturbances, which are easily combined with lipid metabolism disorders, obesity hypertension, diabetes, and other metabolic synthesis (5). Thus, PCOS patients have increased risk of atherosclerosis, which thereby significantly increases the risk of cardiovascular disease (CVD) (5).…”

Section: Introductionmentioning

confidence: 99%

“…PCOS patients often experience metabolic disturbances, which are easily combined with lipid metabolism disorders, obesity hypertension, diabetes, and other metabolic synthesis (5). Thus, PCOS patients have increased risk of atherosclerosis, which thereby significantly increases the risk of cardiovascular disease (CVD) (5).…”

Section: Introductionmentioning

confidence: 99%

Risk of Cardiovascular and Cerebrovascular Events in Polycystic Ovarian Syndrome Women: A Meta-Analysis of Cohort Studies

Zhang

Qu³

2020

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Clinical, Hormonal, and Metabolic Parameters in Women with Subclinical Hypothyroidism and Polycystic Ovary Syndrome: A Cross-Sectional Study

Abstract: Women with PCOS and SCH are more likely to have impaired FPG values and impaired insulin sensitivity even after adjusting for age and BMI. Hence, close monitoring of PCOS patients for SCH may be beneficial.

Cited by 25 publications

References 36 publications

Occurrence of hypothyroidism and its correlation with reproductive health problems: a cross sectional study

Occurrence of hypothyroidism and its correlation with reproductive health problems: a cross sectional study

Subclinical Hypothyroidism in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Risk of Cardiovascular and Cerebrovascular Events in Polycystic Ovarian Syndrome Women: A Meta-Analysis of Cohort Studies

Contact Info

Product

Resources

About