Clinical, immunophenotype and cytogenetic profile of acute lymphoblastic leukemia in children at tertiary health care centre in India

Cytogenetics Findings of Patients With Acute Lymphoblastic Leukemia in West Indian Region.

“…This result is comparable to the findings in the earlier studies (Safaei et al, 2013). The incidence of normal karyotype in the previous studies is reported as 48.32% (Siddaiahgari et al, 2015) and 38.30% (Safaei et al, 2013) while it was 31.42% in our study maybe, due to the improvement in the culture techniques and introduction of interphase FISH technique, which led to higher detection of chromosomal abnormalities as in many other studies which used FISH (Goud et al, 2015).…”

“…Also, there is significant difference between the childhood and adult ALL as indicated by the prevalence of various chromosomal aberrations and other factors (Sabir et al, 2012). Hence, Marwaha and Kulkarni (2011) have emphasized on accurate estimation of incidence and prevalence of ALL in India, which would help to estimate the disease burden, its impact on population and to develop effective treatment strategies (Siddaiahgari et al, 2015).…”

“…Many studies have been conducted on ALL, based on the cytogenetic findings of the patients with ALL (Safaei et al, 2013;Siddaiahgari et al, 2015), FISH analysis of childhood and adult ALL patients (Goud et al, 2015) and Epidemiology of childhood cancers in India (Arora et al, 2009). Also, studies based on significant fusion oncogenes in patients with ALL have been conducted (Sabir et al, 2012).…”

Cytogenetic Profile in 7209 Indian Patients with <i>de novo</i> Acute Leukemia: A Single Centre Study from India

“…Data from various studies from Asian countries also indicated low prevalence (13% -19%) of ETV6/RUNX1 [54]- [56]. Studies have reported incidence rates of <10% from other parts of India, however, these were smaller studies with sample size not large enough to focus on true prevalence [57] [58]. The peak incidence of ETV6/RUNX1 was in lower age group of 1 -10 years as reported in our previous studies as well as in studies from other Asian countries [27] [52] [55] [59].…”

Analysis of outcomes and prognostic factors of acute lymphoblastic leukemia patients treated by MCP841 protocol: A regional cancer center experience

“…[1234] However, reports from various institutions in India suggest that the outcome is inferior to that achieved in the developed nations due to poor management of infections, leading to toxic deaths and also increased incidence of relapse. [5678910] The patient population of India differs markedly from the Western population with respect to the prevalence of illiteracy, poverty, malnutrition, and chronic infectious diseases. Although multiple studies have been performed across the world; there is a deficiency of data available on the prognostic factors, response to treatment, and research on the biology of ALL from the Northwest Indian perspective.…”