Clinical Impact of Delaying Initiation of Adjuvant Chemotherapy in Patients With Breast Cancer

Abstract

TTC influenced survival outcomes in the overall study cohort. This finding was particularly meaningful for patients with stage III BC, TNBC, and trastuzumab-treated HER2-positive tumors who experienced worse outcomes when chemotherapy was delayed. Our findings suggest that early initiation of chemotherapy should be granted for patients in these high-risk groups.

The Impact of Adjuvant Chemotherapy Initiation Time on the Outcome of Cancer Breast

“…A more recent ASCO study was conducted by Gagliato et al [9] on the overall survival, distant-relapse-free survival outcomes according to TTC over 6,827 patients. Overall it agreed with our results as regards the indifferences in terms of OS and DFS between cohorts starting chemotherapy either within 0 to 30 days, 31 to 60 days, or more than 60 days postoperatively.…”

“…A recent ASCO study was conducted on the overall survival, relapse-free survival and distant free survival outcomes according to TTC over 6,827 patients showing that there is indifferences in terms of OS and DFS between different cohorts starting chemotherapy within 0 to up to more than 60 days postoperatively but it showed a significance only with more advanced stage disease who experienced worse outcome in terms of RFS and DRFS (stage II and III) and OS (stage III) if chemotherapy start was delayed for more than 60 days post-operatively [9].…”

Cox Proportional Hazard Survival Analysis to Inpatient Breast Cancer Cases

“…In addition to the clinical stage stage of breast cancer or the type of diagnosis, there are several other prognostic factors associated with survival rate, namely: age [16], race [15] , occupation [17], comorbidity: diabetes [18]; anemia [7] [19], family history [7], tumor size [20] [21], location of lymph node metastasis [11] [21]. Survival rate is also related to type of surgery and treatment, including in chemotherapy [22], breast surgery [23], hormonal [7] and radiotherapy [24].…”

Survival Analysis of Women with Triple Negative Breast Cancer Using EMRLinked Cancer Registry Data in Florida

“…Black women have historically been less likely than Whites to be screened for breast cancer. Additionally, among Black women who undergo screening, delay in the timing of treatment initiation remains a consequence for increased recurrence and lower survival [21][22][23].…”