Clinical impact of periodontal disease on postoperative complications in gastrointestinal cancer patients

Nishikawa, Mao; Honda, Michitaka; Kimura, Ryosuke; Kobayashi, Ayaka; Yamaguchi, Yuji; Kobayashi, Hiroshi; Kawamura, Hidetaka; Nakayama, Yasuhisa; Todate, Yukitoshi; Takano, Yoshinao; Hamada, Koichi; Iketani, Susumu; Seto, Ichiro; Seto, Kanichi

doi:10.1007/s10147-019-01513-y

Cited by 16 publications

(18 citation statements)

References 30 publications

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“…In all patients, we obtained informed consent for written and the oral cavity was evaluated by a dentist and oral management was performed. We previously reported the details [5]. In brief, the dentist examined patients' oral cavity and the severity of PD.…”

Section: Oral Management and Evaluation Of Pdmentioning

confidence: 99%

“…Perioperative oral management has been reported to be effective for preventing postoperative infectious complications (POICs) such as aspiration pneumonia after esophagectomy or other gastrointestinal surgeries [1][2][3][4]. We previously reported that the severity of periodontal disease (PD), as determined by the probing pocket depth, is an important risk factor for POICs after gastrointestinal surgery [5]. While it is easy to understand how the surgical wound or respiratory tract is directly exposed to bacteria from the oral cavity in esophagectomy or head and neck surgery, the infectious route has been still unclear in the other abdominal surgery.…”

Section: Introductionmentioning

confidence: 99%

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The bacterial association with oral cavity and intra-abdominal abscess after gastrectomy

et al. 2020

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Background Perioperative oral management has been reported to be effective for preventing postoperative infectious complications. In addition, severe periodontal disease was identified as the significant risk factor for complications after gastrointestinal surgery. We investigated the bacteriological association between the periodontal pocket, stomach mucosa and drainage fluid to determine whether oral bacteria directly cause intra-abdominal infection after gastrectomy. Methods Patients who were scheduled to undergo surgery for gastric cancer were prospectively enrolled. We evaluated the similarity of bacterial strains in periodontal pocket, stomach mucosa and fluid from drainage tube. Gingival crevicular fluid and dental plaque were collected from the periodontal pocket and cultured to detect bacteria. Specimens from the resected stomach were collected and used for bacterial culturing. Drainage fluid from the abdominal cavity was also cultured. Results All of 52 patients were enrolled. In the periodontal pocket, α-Streptococcus spp., Neisseria sp., and Prevotella sp. were mainly detected. Bacterial cultures in the stomach mucosa were positive in 26 cases. In 20 cases (76.9%), the detected strains were the same as those in the periodontal pocket. Six patients had the postoperative intra-abdominal infection after gastrectomy, and the same bacterial strains was detected in both of drainage fluid and periodontal pocket in two patients with severe periodontal disease. Conclusions We found the bacteriological association that same strain detected in periodontal pocket, stomach and in intra-abdominal drainage fluid after gastrectomy in patients with periodontal disease.

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Section: Oral Management and Evaluation Of Pdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The bacterial association with oral cavity and intra-abdominal abscess after gastrectomy

et al. 2020

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“…Indeed, its preventive effect has been reported for aspiration pneumonia (Bergan et al, 2014;Ishimaru et al, 2018;Spreadborough et al, 2016;Wren et al, 2010;Yoneyama et al, 1999) and infective endocarditis (Cotti et al, 2017;Lockhart et al, 2009;Nakatani et al, 2003;Silvestre et al, 2017;Wilson et al, 2007). We previously identified the risk associated with the oral condition and reported that severe periodontal disease in particular was an independent risk factor for infectious complications after gastrointestinal surgery (Nishikawa et al, 2019). Therefore, we hypothesized that preoperative treatment of periodontal disease might help improve the surgical outcomes.…”

Section: Introductionmentioning

confidence: 99%

The effects of intensive oral care before surgery for gastric cancer patients

et al. 2020

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Objectives: Oral function management has been recognized as important strategy for preventing postoperative complications. In this historical cohort study, we focused on the patients who planed gastrectomy, and investigated the appropriate duration and frequency of preoperative oral care to prevent complications after surgery. Methods: Patients who planed surgery for gastric cancer between 2012 and 2018 were enrolled. We defined intensive oral care (IOC) as initial intervention at least three weeks before surgery and follow-up intervention within a week before surgery.As the primary outcome, the incidence of postoperative infectious complications was compared between the IOC and non-intensive oral care groups.Results: A total of 576 patients were enrolled, including 66 with IOC. The incidence of infectious complications was 2/66 (3.0%) in the IOC group and 64/510 (12.5%) in the non-intensive oral care group. After adjusting for confounding factors, patients with IOC exposure had a lower chance of developing postoperative infectious complications (odds ratio; 0.217, 0.051-0.927). Conclusions:Intensive oral care can help prevent postoperative infectious complications after gastrectomy. These findings suggest that appropriate preoperative oral care includes at least two interventions: three weeks or more before and within one week before surgery.

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“…Many studies have shown that the oral cavity may be the main endogenous pathogen reservoir of POP 14 . Periodontal disease is a risk factor for infectious complications after surgery 15 . There has been a high incidence of periodontitis reported among patients with lung or esophageal cancer 16 .…”

Section: Introductionmentioning

confidence: 99%

Effects of periodontitis on postoperative pneumonia in patients with lung and esophageal cancer

Jia

Luan

et al. 2021

Thoracic Cancer

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Background Few studies have been conducted on the relationship between chronic periodontitis and postoperative pneumonia (POP) in patients with lung and esophageal cancer. Furthermore, it remains controversial as to whether improving the periodontal condition of patients with lung and esophageal cancer before surgery reduces the incidence of POP. This retrospective study was conducted to assess the effects of periodontal therapy in patients with lung and esophageal cancer to prevent POP. Methods A total of 265 patients with lung or esophageal cancer complicated with chronic periodontitis who underwent open thoracotomy between July 2015 and June 2019 were selected and given the choice of being in the experimental or control group. A total of 141 participants in the experimental group received periodontal therapy, and 124 participants in the control group did not receive periodontal therapy. All clinical data of participants in both groups were retrospectively studied to determine the incidence of POP on the 30th day after discharge from hospital. Results Eight patients in the experimental and six in the control group, respectively, were excluded from the study. It was found that four of the 133 patients suffered from POP in the experimental group (incidence: 3.01%). A total of 18 of 118 patients in the control group had a pulmonary infection (incidence: 15.25%). POP incidence in the experimental group was significantly lower than that in the control group, and in the level analysis of different types of periodontitis, surgical methods, and diseases (p < 0.05). Conclusions Periodontal treatment is associated with a lower incidence of POP following lung and esophageal cancer surgery. Improving the periodontal condition of patients helps prevent POP. The presence of periodontitis is an important predisposing factor for POP in patients after open thoracotomy. Periodontal examination and therapy are recommended before the surgical treatment of lung or esophageal cancer.

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Clinical impact of periodontal disease on postoperative complications in gastrointestinal cancer patients

Cited by 16 publications

References 30 publications

The bacterial association with oral cavity and intra-abdominal abscess after gastrectomy

The bacterial association with oral cavity and intra-abdominal abscess after gastrectomy

The effects of intensive oral care before surgery for gastric cancer patients

Effects of periodontitis on postoperative pneumonia in patients with lung and esophageal cancer

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