Clinical impact of primary tumor sidedness and sex on unresectable post-recurrence survival in resected pathological stage II-III colorectal cancers: a nationwide multicenter retrospective study

Abe, Shinya; Kawai, Kazushige; Nozawa, Hiroaki; Sasaki, Kazuhito; Murono, Koji; Emoto, Shigenobu; Ozawa, Tomohiro; Yokoyama, Yuichiro; Nagai, Yoshinori; Anzai, Hiroyuki; Sonoda, Hirofumi; Yamauchi, Shinichi; Sugihara, Kenichi; Ishihara, Soichiro

doi:10.1186/s12885-022-09615-z

Cited by 6 publications

(3 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Biomarkers could be utilized as stimulus changers or prognostic factors for unique type of therapy, as well as to select the effective type of treatment. KRAS is a predictive biomarker for colorectal cancer; mutations occurring to KRAS in somatic cells are related to low response to anti-EGFR-mediated treatment [ 60 , 61 ]. Likewise, HER2 over-expression in the breast cancer as well as gastric cancer anticipates for stimulus to anti-Her2 drugs such as trastuzumab [ 62 , 63 , 64 , 65 , 66 , 67 ], and over-expression of estrogen receptor anticipates for stimulus to anti-endocrine therapy or treatment such as tamoxifen in breast cancer [ 68 , 69 ].…”

Section: Cancer Biomarkersmentioning

confidence: 99%

Recent Trends in Biosensing and Diagnostic Methods for Novel Cancer Biomarkers

et al. 2023

View full text Add to dashboard Cite

Cancer is one of the major public health issues in the world. It has become the second leading cause of death, with approximately 75% of cancer deaths transpiring in low- or middle-income countries. It causes a heavy global economic cost estimated at more than a trillion dollars per year. The most common cancers are breast, colon, rectum, prostate, and lung cancers. Many of these cancers can be treated effectively and cured if detected at the primary stage. Nowadays, around 50% of cancers are detected at late stages, leading to serious health complications and death. Early diagnosis of cancer diseases substantially increases the efficient treatment and high chances of survival. Biosensors are one of the potential screening methodologies useful in the early screening of cancer biomarkers. This review summarizes the recent findings about novel cancer biomarkers and their advantages over traditional biomarkers, and novel biosensing and diagnostic methods for them; thus, this review may be helpful in the early recognition and monitoring of treatment response of various human cancers.

show abstract

Section: Cancer Biomarkersmentioning

confidence: 99%

Recent Trends in Biosensing and Diagnostic Methods for Novel Cancer Biomarkers

et al. 2023

View full text Add to dashboard Cite

show abstract

“…In the past several years, primary tumor sidedness has been recognized as the predictive value of prognosis of colon cancer patients. Right-sidedness was demonstrated to be associated with poor survival in the colon cancer patients with metastasis [4][5][6][7][8], stage III [9], stage II-III microsatellite stable [10], unresectable recurrence [11]. However, the difference between right-sided and left-sided colon cancer in surgical outcome has seldom been reported on and continues to be controversial [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Primary Tumor Sidedness Associated with Clinical Characteristics and Postoperative Outcomes in Colon Cancer Patients: A Propensity Score Matching Analysis

Hu,

Eisenstein,

Parry

et al. 2024

JCM

View full text Add to dashboard Cite

Background: Recent investigations have suggested that-sidedness is associated with the prognosis of colon cancer patients. However, the role of sidedness in surgical outcome is unclear. In this study, we tried to demonstrate the real role of sidedness in postoperative results for colon cancer patients receiving surgical intervention. Methods: This is a propensity score matching study using the database of the American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) from 2009 to 2013. Sidedness groups including right-sided and left-sided colon cancer were created according to the associated diagnosis and procedure codes. Postoperative 30-day mortality, morbidity, overall complications, and total length of hospital stay were analyzed after performing propensity score matching. Results: Out of a total of 24,436 colon cancer patients who received associated operations, 15,945 patients had right-sided cancer and 8941 patients had left-sided cancer. Right-sided colon cancer patients were accompanied by more preoperative comorbidities including old age, female sex, hypertension, dyspnea, anemia, hypoalbuminemia, and a high American Society of Anesthesiologists grade (SMD > 0.1). Postoperative mortality, morbidities including re-intubation, bleeding, urinary tract infection and deep vein thrombosis, postoperative overall complications, and total length of hospital stay were significantly associated with right-sided cancer (p < 0.05). After 1:1 propensity score matching, postoperative mortality was not significantly different between right-sided cancer (2.3%) and left-sided cancer (2.4%) patients. The patients with left-sided colon cancer had significantly more postoperative morbidities, more overall complications, and longer total length of hospital stay. Conclusions: Poor clinical characteristics and postoperative outcomes were noted in right-sided cancer patients. After propensity score matching, left-sided cancer patients had worse postoperative outcomes than those with right-sided cancer.

show abstract

“…9 Risk of recurrence has been reported to be higher in men than in women, and in people with rectal cancer compared to people with colon cancer. 9,10 Furthermore, the localisation of recurrences also seems to differ per location of the primary tumour, 9,11 and may differ for men and women, 11 implying different underlying mechanisms are involved leading to cancer recurrence.…”

Section: Introductionmentioning

confidence: 99%

Associations between low‐ and high‐fat dairy intake and recurrence risk in people with stage I–III colorectal cancer differ by sex and primary tumour location

van Lanen,

Kok,

Wesselink

et al. 2024

Intl Journal of Cancer

View full text Add to dashboard Cite

We previously demonstrated that intake of low‐fat dairy, but not high‐fat dairy, was associated with a decreased colorectal cancer (CRC) recurrence risk. These risks, however, may differ by sex, primary tumour location, and disease stage. Combining data from two similar prospective cohort studies of people with stage I–III CRC enabled these subgroup analyses. Participants completed a food frequency questionnaire at diagnosis (n = 2283). We examined associations between low‐ and high‐fat dairy intake and recurrence risk using multivariable Cox proportional hazard models, stratified by sex, and primary tumour location (colon and rectum), and disease stage (I/II and III). Upper quartiles were compared to lower quartiles of intake, and recurrence was defined as a locoregional recurrence and/or metastasis. During a median follow‐up of 5.0 years, 331 recurrences were detected. A higher intake of low‐fat dairy was associated with a reduced risk of recurrence (hazard ratio [HR]: 0.60, 95% confidence interval [CI]: 0.43–0.83), which seemed more pronounced in men (HR: 0.51, 95% CI: 0.34–0.77) than in women (HR: 0.84, 95% CI: 0.47–1.49). A higher intake of high‐fat dairy was associated with an increased risk of recurrence in participants with colon cancer (HR: 1.60, 95% CI: 1.03–2.50), but not rectal cancer (HR: 0.88, 95% CI: 0.54–1.45). No differences in associations were observed between strata of disease stage. Concluding, our findings imply that dietary advice regarding low‐fat dairy intake may be especially important for men with CRC, and that dietary advice regarding high‐fat dairy intake may be specifically important in people with colon cancer.

show abstract

Clinical impact of primary tumor sidedness and sex on unresectable post-recurrence survival in resected pathological stage II-III colorectal cancers: a nationwide multicenter retrospective study

Cited by 6 publications

References 52 publications

Recent Trends in Biosensing and Diagnostic Methods for Novel Cancer Biomarkers

Recent Trends in Biosensing and Diagnostic Methods for Novel Cancer Biomarkers

Primary Tumor Sidedness Associated with Clinical Characteristics and Postoperative Outcomes in Colon Cancer Patients: A Propensity Score Matching Analysis

Associations between low‐ and high‐fat dairy intake and recurrence risk in people with stage I–III colorectal cancer differ by sex and primary tumour location

Contact Info

Product

Resources

About