Clinical impact of stent construction and design in percutaneous coronary intervention

Lau, Kean‐Wah; Mak, Koon‐Hou; Hung, Jui‐Sung; Sigwart, Ulrich

doi:10.1016/j.ahj.2003.12.007

Cited by 55 publications

(41 citation statements)

References 76 publications

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“…Unfortunately, the clinical results of coronary artery stenting could not always confirm its theoretical advantages [27]. The rates of thrombus formation and restenosis of coated stents were either higher than or equal to those of bare-metal stents.…”

Section: Coated Stentsmentioning

confidence: 99%

The Development of Carotid Stent Material

Liu

Zhang

2014

Intervent Neurol

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Endovascular angioplasty with stenting is a promising option for treating carotid artery stenosis. There exist a rapidly increasing number of different stent types with different materials. The bare-metal stent is the most commonly used stent with acceptable results, but it leaves us with the problems of thrombosis and restenosis. The drug-eluting stent is a breakthrough as it has the ability to reduce the restenosis rate, but the problem of late thrombosis still has to be addressed. The biodegradable stent disappears after having served its function. However, restenosis and degradation rates remain to be studied. In this article, we review every stent material with its characteristics, clinical results and complications and point out the standards of an ideal carotid stent. © 2014 S. Karger AG, Basel

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Section: Coated Stentsmentioning

confidence: 99%

The Development of Carotid Stent Material

Liu

Zhang

2014

Intervent Neurol

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“…Several pharmaceutical approaches including delivery of antihypertensive agents, calcium channel blockers, lipid-lowering drugs and antioxidants have shown limited success in treating restenosis [5,6,9,10]. Best and most acceptable way to reduce restenosis rate in the clinic is with stents, by providing a larger initial lumen diameter, covering vessel dissections and supporting the expanded artery with sufficient rigidity [11,12]. Although there is some success with restenosis problem by utilizing stent based approach, there is still a need for anti restenotic drug-based therapy.…”

Section: Arterial Injury Response To Neointimal Hyperplasiamentioning

confidence: 99%

Review on Nitric Oxide, Carbon Monoxide and Antisense Based Therapy towards Treatment of Restenosis

Ramadugu¹,

Alikatte²,

Dhudipala³

et al. 2016

J Bioequiv Availab

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“…However, ePTFE which is the most common method for hemodialysis grafts has improved biocompatibility: this is because it is biologically inert, chemically and thermally stable and has excellent mechanical and anti-frictional properties. [9][10][11] In this study, a controlled release from this biocompatible ePTFE polymer matrix is presented. It has been previously reported that paclitaxel coated by dipping and evaporation of solvent on ePTFE can adhere to the pitted polymer surface.…”

Section: Introductionmentioning

confidence: 99%

Reduced Burst Release from ePTFE Grafts: A New Coating Method for Controlled Drug Release

Nam¹,

Kim²,

Lim³

et al. 2008

Bulletin of the Korean Chemical Society

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Hemodialysis graft coated with paclitaxel prevents stenosis; however, large initial burst release of paclitaxel causes many negative effects such as drug toxicity and inefficient drug loss. Therefore we developed and tested a novel coating method, double dipping, to provide controlled and sustained release of paclitaxel locally. Expanded polytetrafluoroethylene (ePTFE) grafts were dipped twice into a solution of several different paclitaxel concentrations. In vitro release tests of the double dipping method showed that early burst release could be somewhat retarded and followed by sustained release for a long time. We observed the effect of paclitaxel coating by double dipping in porcine model of arterio-venous (AV) grafts between the common carotid artery and the external jugular vein. 12 weeks after constructing AV grafts, cross sections of the graft venous anastomosis were obtained and analyzed. Paclitaxel coated ePTFE grafts by double dipping were observed to prevent neointimal hyperplasia and therefore reduced stenosis of the arteriovenous hemodialysis grafts, especially at the graft venous anastomosis sites. Our results demonstrate that second dipping of ePTFE graft, which was already coated once with paclitaxel, washes off the drug on a surface of the graft and affects the ratio of paclitaxel on the surface to that of the inner space, possibly by diffusion: thus the early burst of drug can be somewhat reduced.

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Clinical impact of stent construction and design in percutaneous coronary intervention

Cited by 55 publications

References 76 publications

The Development of Carotid Stent Material

The Development of Carotid Stent Material

Review on Nitric Oxide, Carbon Monoxide and Antisense Based Therapy towards Treatment of Restenosis

Reduced Burst Release from ePTFE Grafts: A New Coating Method for Controlled Drug Release

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