Clinical Implementation of Platelet- and Extracellular Vesicle-Rich Product Preparation Protocols

Steiner, Nejc; Vozel, Domen; Urbančič, Jure; Božič, Darja; Kralj‐Iglič, Veronika; Battelino, Saba

doi:10.1089/ten.tea.2022.0024

Cited by 5 publications

(7 citation statements)

References 29 publications

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“…The complexity of interactions influencing PVRP composition-related specific host characteristics emphasize the importance of individual consideration of PVRP products in clinical use [ 12 , 69 ].…”

Section: Composition Of Plasma Rich With Platelets and Extracellular ...mentioning

confidence: 99%

“…For therapeutic preparations, the processing can be performed immediately after blood harvesting in a laboratory, operating room or outpatient clinic. Depending on the method, blood withdrawal volume can be estimated based on platelet yield [ 11 , 69 ]. The volume of withdrawn blood depends on the requirement to cover the targeted area.…”

Section: Preparation Of Platelet and Extracellular Vesicle-rich Plasmamentioning

confidence: 99%

“…Withdrawn blood needs to be anticoagulated to prevent platelets to coalesce into a clot and disable the release of bioactive molecules. This is usually performed by blood withdrawal into sodium citrate tubes [ 69 ].…”

Section: Preparation Of Platelet and Extracellular Vesicle-rich Plasmamentioning

confidence: 99%

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Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review

Troha

Vozel

Arko

et al. 2023

IJMS

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The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has been explored in many medical fields with the aim to benefit from its healing potential. In parallel, efforts are being invested to understand the function and dynamics of PVRP that is complex in its composition and interactions. Some clinical evidence reveals beneficial effects of PVRP, while some report that there were no effects. To optimize the preparation methods, functions and mechanisms of PVRP, its constituents should be better understood. With the intention to promote further studies of autologous therapeutic PVRP, we performed a review on some topics regarding PVRP composition, harvesting, assessment and preservation, and also on clinical experience following PVRP application in humans and animals. Besides the acknowledged actions of platelets, leukocytes and different molecules, we focus on extracellular vesicles that were found abundant in PVRP.

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Section: Composition Of Plasma Rich With Platelets and Extracellular ...mentioning

confidence: 99%

Section: Preparation Of Platelet and Extracellular Vesicle-rich Plasmamentioning

confidence: 99%

See 1 more Smart Citation

Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review

Troha

Vozel

Arko

et al. 2023

IJMS

Self Cite

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“…where VPVRP =η * Vblood for PVRP (5) and η is the proportion of PVRP in blood. For the "half volume" protocol, η = 0.5 (Steiner et al, 2022). Volume of serum can be expressed by haematocrit Ht,…”

Section: Total Blood Volume Calculations For Pvrg Preparationmentioning

confidence: 99%

“…a "half volume" protocol where we calculated the time needed for the upper border of erythrocytes to arrive down to one half of the length of the blood sample. We derived equations for exact calculations of blood volumes needed to treat the wound of the individual patient and provided a calculator to alleviate calculations (Steiner et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Pelvic Osteotomies in Children and Adults - Experience of University Medical Centre Ljubljana

Kovačić¹,

Zore²,

Stražar³

2022

Socratic Lectures 7

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Nowadays, hip dysplasia is recognized and treated mainly conservatively due to good screening program and early detection. There are still some cases found after first year of life, in later childhood and in adults. These cases are treated with pelvic osteotomies to improve femoral head coverage and joint stability and to decrease the hip stress with the final goal to preserve the joint in longer term. There are three subtypes of pelvic osteotomies. The ones pertaining to first type are redirectional osteotomies, which are incomplete osteotomies with the aim to reduce overall volume and redirect the acetabulum by a hinge located between triradiate cartilage and pubic symphysis. This type in-cludes Salter, Pemberton, Dega and San Diego osteotomies. The osteotomies pertaining to the second type are reorientational osteotomies, which are complete osteotomies with the aim to reorient the whole acetabulum. This type includes periacetabular and triple osteotomies. The osteotomies per-taining to the third type are salvage osteotomies which enlarge the acetabulum and medialise the hip center in arhritic and/or incongruent joint and are performed in hips in which the reorientational osteotomy is contraindicated. This type includes shelf and Chiari osteotomies. In University Medical Centre Ljubljana, most of the above-mentioned osteotomies are being performed, however, yearly numbers are small. Redirectional osteotomies have been performed for many years in the Pediatric orthopaedic department and yearly number is under 10 cases. Reorientational osteotomies on young adults are made through minimally invasive approach for periacetabular osteotomy described by Soebbale at al. (2015). In selected cases, electromagnetic surgical navigation system is used for more precise positioning of the acetabular fragment. Keywords: Hip dysplasia, pelvic osteotomy, periacetabular osteotomy, hip preservation, hip pain

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Theoretical description of particle sedimentation in blood considering hematocrit: A 2nd generation mathematical model

Berry,

Kralj-Iglič

2023

Advances in Biomembranes and Lipid Self-Assembly

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Clinical Implementation of Platelet- and Extracellular Vesicle-Rich Product Preparation Protocols

Cited by 5 publications

References 29 publications

Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review

Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review

Pelvic Osteotomies in Children and Adults - Experience of University Medical Centre Ljubljana

Theoretical description of particle sedimentation in blood considering hematocrit: A 2nd generation mathematical model

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