Clinical Implications of Nonbiological Factors With Colorectal Cancer Patients Younger Than 45 Years

Abstract

BackgroundTo evaluate the clinical implications of non-biological factors (NBFs) with colorectal cancer (CRC) patients younger than 45 years.MethodsIn the present study, we have conducted Cox proportional hazard regression analyses to evaluate the prognosis of different prognostic factors, the hazard ratios (HRs) were shown with 95% confidence intervals (CIs). Kaplan–Meier method was utilized to compare the prognostic value of different factors with the log-rank test. NBF score was established according to the result of multivariate Cox analyses.ResultsIn total, 15129 patients before 45 years with known NBFs were identified from the SEER database. Only county-level median household income, marital status and insurance status were NBFs that significantly corelated with the cause specifical survival in CRC patients aged less than 45 years old (P < 0.05). Stage NBF 1 showed 50.5% increased risk of CRC-specific mortality (HR = 1.505, 95% CI = 1.411-1.606, P < 0.001). Stage NBF 0 patients were associated with significantly increased CRC-specific survival (CCSS) when compared with the stage NBF 1 patients in different AJCC TNM stages.ConclusionsNBF stage (defined by county-level median household income, marital status and insurance status) was strongly related to the prognosis of CRC patients. NBFs should arouse enough attention of us in clinical practice of patients younger than 45 years.

Prognostic relevance of rib invasion and modification of T description for resected NSCLC patients: A propensity score matching analysis of the SEER database

“…SEER*stat software (version 8.4.0.1) was used to retrieve cases from the SEER database, which is a comprehensive source of demographic information on clinicopathological characteristics and survival of cancer patients in the USA ( 13 ). Data were collected only after official permission had been granted (username: 12238-Nov2021) and did not require informed consent from patients.…”

“…The prognosis of patients with different depths of chest wall involvement is controversial, and the survival difference was reported to be non-significant in a few studies (4)(5)(6)(7)(8)(9). Meanwhile, recent studies demonstrated that the depth of chest wall involvement was an independent prognostic risk factor, and the survival rate of patients with deper chest wall invasion was worse than that of patients with chest wall invasion limited to the parietal pleura (10)(11)(12)(13). At present, most studies have reported that the depth of chest wall infiltration can affect long-term survival, but only one study specifically investigated the impact of rib invasion on the T classifications (14).…”