Clinical implications of pretreatment inflammatory biomarkers as independent prognostic indicators in prostate cancer

Sun, Zhonghua; Ju, Ying; Han, Fuyan; Sun, Xiya; Wang, Fang

doi:10.1002/jcla.22277

Cited by 33 publications

(28 citation statements)

References 30 publications

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“…At last, 6 articles published between 2015 and 2017 were included for meta-analysis. Three studies were performed in China, [ 14 , 16 , 18 ] one was conducted in Spain, [ 15 ] one in Italy, [ 17 ] and one in Austria. [ 19 ] All 6 studies reported data on overall survival (OS) and 4 studies showed data on disease-free survival (DFS).…”

Section: Resultsmentioning

confidence: 99%

“…[ 19 ] All 6 studies reported data on overall survival (OS) and 4 studies showed data on disease-free survival (DFS). [ 14 – 16 , 19 ] The cut-off values of PLR ranged from 117.58 to 210. All studies had a retrospective study design and a Newcastle–Ottawa scale (NOS) score ≥6.…”

Section: Resultsmentioning

confidence: 99%

“…Six studies [ 14 – 19 ] with a total of 1324 patients investigated the association of PLR and OS in PCa. Because of the lack of heterogeneity ( I 2 = 0, P = .906), a fixed-effects model was used.…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies have explored the prognostic role of PLR in patients with PCa, although the results are controversial. [ 14 – 19 ] To perform an insightful investigation on the association of PLR and clinical outcomes in PCa, we thoroughly searched relevant publications and conducted a quantitative pooled analysis.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic role of platelet to lymphocyte ratio in prostate cancer

Wang

Zhou

et al. 2018

Medicine

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Background:Recently, the prognostic value of the platelet-to-lymphocyte ratio (PLR) has been identified in multiple cancers. However, the prognostic significance of the PLR in prostate cancer (PCa) remains conflicting. We therefore searched relevant studies and conducted a meta-analysis.Methods:Papers from the databases of PubMed, Web of Science, and the Cochrane Library were retrieved. Six studies comprising 1324 patients were included.Results:The pooled analysis demonstrated that an elevated PLR predicted poor overall survival (OS; HR = 1.85, 95% CI = 1.51–2.25, P < .001) and disease-free survival (DFS; HR = 1.4, 95% CI = 1.1–1.79, P = .007). Subgroup analyses showed that the PLR remained a significant prognostic factor for OS irrespective of ethnicity, tumor stage, or cut-off value. The PLR was an indicator of poor DFS in Asian patients, but not in Caucasian patients. No significant publication bias was detected.Conclusion:This meta-analysis showed that a high PLR was correlated with poor DFS and OS in patients with prostate cancer. Due to this meta-analysis being derived from a few studies, the results should be validated in clinical practice.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic role of platelet to lymphocyte ratio in prostate cancer

Wang

Zhou

et al. 2018

Medicine

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“…RDW is a parameter that reflects the heterogeneity of peripheral red blood cell volume and is considered to be a systemic inflammatory marker of in many chronic inflammation . As a low‐cost test, it is usually reported in the complete blood counts .…”

Section: Discussionmentioning

confidence: 99%

The potential value of red blood cell distribution width in patients with invasive hydatidiform mole

Zhang

Xie

Zhan

2019

Clinical Laboratory Analysis

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BackgroundRed blood cell distribution width (RDW) has attracted increasing attention in cancer. The aim of this study was to assess the changes of RDW in patients with invasive hydatidiform mole and analyze the relationship between RDW and invasive hydatidiform mole.MethodsA retrospective analysis was performed on 102 patients diagnosed as invasive hydatidiform mole in the First Affiliated Hospital of Guangxi Medical University from January 2009 to March 2018. A total of 120 healthy subjects were used as a control group. The Mann‐Whitney U test was used for comparison between the invasive hydatidiform mole and control groups. Comparison of RDW with other blood parameters was performed using Spearman's. The area under the ROC curve (AUC) and 95% confidence interval (95% CI) were also determined.ResultsThe RDW, platelet‐lymphocyte ratio (PLR), neutrophil‐lymphocyte ratio (NLR), and absolute lymphocyte count were significantly elevated in the invasive hydatidiform mole group compared with control group. The hemoglobin (Hb) concentration, mean red blood cell volume (MCV) and platelet count (PLT) were significantly lower in invasive hydatidiform mole group than control group. Grade III and above invasive hydatidiform mole patients had higher levels of RDW than grade I and II patients. Correlation analysis showed that RDW was negatively correlated with Hb, MCV, NLR, and neutrophil count, but positively correlated with PDW and different stages of invasive hydatidiform mole. The ROC curve showed that the AUC of the RDW was 0.660 (95% CI 0.581‐0.740; P < 0.01).ConclusionThis study reveals the potential value of RDW in invasive hydatidiform mole.

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Systemic inflammation with sarcopenia predicts survival in patients with gastric cancer

Liu

Ruan

et al. 2022

J Cancer Res Clin Oncol

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Clinical implications of pretreatment inflammatory biomarkers as independent prognostic indicators in prostate cancer

Abstract: The pretreatment NLR and PLR might be beneficial to predict the progression and prognosis of PCa. Furthermore, NLR was more effective than PLR acting as an independent prognostic indicator for PCa.

Cited by 33 publications

References 30 publications

Prognostic role of platelet to lymphocyte ratio in prostate cancer

Prognostic role of platelet to lymphocyte ratio in prostate cancer

The potential value of red blood cell distribution width in patients with invasive hydatidiform mole

Systemic inflammation with sarcopenia predicts survival in patients with gastric cancer

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