Clinical implications of the tumor necrosis factor family in benign and malignant hematologic disorders

Younes, Anas; Aggarwall, Bharat B.

doi:10.1002/cncr.11524

Cited by 67 publications

(67 citation statements)

References 135 publications

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“…40 The TNF-␣ -857 T allele has been associated with a decreased risk of Crohn's disease, 22,40 another immune-mediated disease characterized by marked lymphocyte infiltration. Since dysregulated TNF-␣ signal transduction contributes directly to the transformed state in many human lymphoid cancers, especially those of B-cell origin, 41 this may partly explain why the genetically determined low TNF-␣ secretor (TNF-␣ -857 T allele) protects against the development of maltoma. Collectively, these data indicate a central role of TNF-␣ in lymphoid proliferation and a decrease of NF-B transactivation by the TNF-␣ -857 T allele.…”

Section: Discussionmentioning

confidence: 99%

Promoter polymorphisms of tumor necrosis factor‐α are associated with risk of gastric mucosa–associated lymphoid tissue lymphoma

Chen

Shun

et al. 2004

Intl Journal of Cancer

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Genes involved in regulating antimicrobial immunity and inflammation may modulate the risk of Helicobacter pyloriassociated diseases. IL-1 and TNF-␣ are major cytokines detected in H. pylori-infected tissues. We aimed to determine the role of gene polymorphisms for these cytokines and their receptors in 2 distinct H. pylori-related gastric malignancies, adenocarcinoma (GAC) and maltoma. Genotyping for IL-1␤ (-31 C/T, -511 C/T), TNF-␣ (-238 G/A, -308 G/A, -857 C/T, -863 C/A, -1031 T/C), TNFR1 (-383 A/C) and TNFR2 (196 G/T) was undertaken for 70 patients with maltoma and 204 patients with noncardia GAC and compared to 210 unrelated healthy controls. Genotype frequencies showed no differences among patients with GAC or maltoma and controls for IL-1␤, TNFR1 or TNFR2. The TNF-␣ -857 T variant was significantly underrepresented in maltoma compared to controls (6.4% vs. 14.3%, p ‫؍‬ 0.018), conferring a 3-fold decrease in risk (OR ‫؍‬ 0.33, 95% CI 0.15-0.75). Comparison of allele frequencies between GAC and controls failed to show any statistical significance for TNF-␣ polymorphisms. We concluded that TNF-␣ -857 T itself or a neighboring gene may modify the risk of maltoma. The differences in genetic background as well as divergent clinicopathologic features between GAC and maltoma support the notion that fundamental mechanistic differences exist in these 2 welldefined H. pylori-related malignancies.

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Section: Discussionmentioning

confidence: 99%

Promoter polymorphisms of tumor necrosis factor‐α are associated with risk of gastric mucosa–associated lymphoid tissue lymphoma

Chen

Shun

et al. 2004

Intl Journal of Cancer

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“…10,11 However, many human tumors including hematologic malignancies are partially or completely resistant to monotherapy with TRAIL, limiting its therapeutic utility. [10][11][12][13] In childhood acute lymphoblastic leukemia (ALL), we previously reported that 50% of pretreatment samples are resistant to TRAIL-induced apoptosis and that TRAIL even stimulates survival and proliferation in some of the resistant patients. 14 This highlights the demand to develop TRAIL-based combination therapies that counter resistance mechanisms of acute leukemia cells toward TRAIL to ensure the success of TRAIL in the clinic.…”

Section: Introductionmentioning

confidence: 99%

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2–mediated resistance

Fakler

Loeder

Vogler

et al. 2009

Blood

129

120

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“…plastic large cell lymphoma (ALCL), multiple myeloma, and adult T-cell leukemia (2)(3)(4). The fact that CD30 is present normally on only a very small fraction of activated B-and T-cells makes it an attractive target for therapeutic intervention.…”

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confidence: 99%

CD30 Activates Both the Canonical and Alternative NF-κB Pathways in Anaplastic Large Cell Lymphoma Cells

Wright

Rumble

Duckett

2007

Journal of Biological Chemistry

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waf1 . Furthermore, p21 waf1 expression and cell cycle arrest were found to depend predominantly on the canonical NF-B pathway, since it was reversed by RNA interference-mediated suppression of RelA. In contrast, suppression of the p100/p52 NF-B subunit had little effect on p21 waf1 . These data reveal that in ALCL cells, in contrast to other cell types, CD30 stimulation elicits p21 waf1 -mediated arrest through the canonical but not the alternative NF-B pathway.

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Clinical implications of the tumor necrosis factor family in benign and malignant hematologic disorders

Abstract: Tumor necrosis factor (TNF), originally identified as a factor produced in the serum of endotoxin-injected animals, is a cytokine that mediates tumor necrosis. To date,

Cited by 67 publications

References 135 publications

Promoter polymorphisms of tumor necrosis factor‐α are associated with risk of gastric mucosa–associated lymphoid tissue lymphoma

Promoter polymorphisms of tumor necrosis factor‐α are associated with risk of gastric mucosa–associated lymphoid tissue lymphoma

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2–mediated resistance

CD30 Activates Both the Canonical and Alternative NF-κB Pathways in Anaplastic Large Cell Lymphoma Cells

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