Clinical implications of trace elements in endocrinology

Nève, Jean

doi:10.1007/bf02784602

Cited by 39 publications

(14 citation statements)

References 58 publications

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“…Also, water treatment is intensified whilst the influence on iodine nutrition is unsettled. Because iodine in humic substances in drinking water is bio-available and influences iodine nutrition [38] and health [2,3,12,20,41] and because characteristics of humic substances and the influence on iodine in drinking water may differ between aquifers, it is important to maintain focus on iodine in drinking water.…”

Section: Discussionmentioning

confidence: 99%

Speciation of Iodine in High Iodine Groundwater in China Associated with Goitre and Hypothyroidism

Andersen

Guan

Wang

et al. 2008

Biol Trace Elem Res

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Iodine intake affects the occurrence of disease in a population. Excessive iodine intake may be caused by a high iodine content of drinking water. Tap water in few locations in Europe contains up to 139 microg/L mostly bound to humic substances, probably leaching from marine sediments in the aquifers. Even higher iodine contents have been found in Chinese waters, previously shown to associate with goitre and hypothyroidism. The aims were to elucidate speciation of high iodine groundwater from deep wells in China and to compare with high iodine waters from Europe. Water was sampled from eight wells in five villages along Bohai Bay, China. Macro-molecules and low molecular weight (MW) substances were separated by size exclusion chromatography (high performance liquid chromatography, Superose 12 HR 10/30, buffer 0.1 M Tris, pH 7.0). Organic material was evaluated by A280 and iodine in fractions measured by the Ce/As method after alkaline incineration. Iodine content of well water varied from 135 to 880 microg/L (median 287 microg/L). The amount of organic material in water was low with A280, <1-5 mAU. The chromatographic traces were similar between samples: One peak of iodine eluted around K (AV) 0.65 corresponding to MW 5 kDa (humic substances) and one peak at V (total) (iodide/low MW substances). The fraction of iodine in macro-molecules, suggested to be humic substances, varied from 8% to 70% (median 27%). Iodine and peak absorbance were associated (p = 0.006). In conclusion, iodine in iodine-rich deep well water in northern China may have marine origin and may associate with humic substances, comparable to shallow well iodine-rich water in Europe. High iodine intake from iodine-rich water suggests the cause of endemic goitre and hypothyroidism in some areas in China being iodine.

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Section: Discussionmentioning

confidence: 99%

Speciation of Iodine in High Iodine Groundwater in China Associated with Goitre and Hypothyroidism

Andersen

Guan

Wang

et al. 2008

Biol Trace Elem Res

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“…However, both in vitro and in vivo studies have shown that administration of large doses of selenium exerts adverse effects such as nervousness, fever, vomiting, somnolence, and severe hypotension (12,13). Endocrine dysfunction including growth reduction has also been reported (14,15).…”

Section: Introductionmentioning

confidence: 99%

Inhibition by Selenium Compounds of Catecholamine Secretion Due to Inhibition of Ca2+ Influx in Cultured Bovine Adrenal Chromaffin Cells

et al. 2006

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Abstract. Selenium is an essential trace metal element, whereas large doses of selenium exert adverse effects to the human body. We examined the effects of selenium compounds, sodium selenite (Na 2 SeO 3 ) and sodium selenate (Na 2 SeO 4 ), on catecholamine secretion from cultured bovine adrenal chromaffin cells. Treatment of chromaffin cells with sodium selenite for 72, 48, and 24 h caused decreases in protein and catecholamine contents, in association with cell damage, at concentrations over 30, 300, and 300 µM, respectively. The cells treated with subtoxic conditions (<100 µM, 48 h) of sodium selenite were used for further experiments. Sodium selenite treatment for 48 h inhibited carbachol (CCh)-induced catecholamine secretion in a concentration-dependent and non-competitive manner, while it did not affect high K + -and veratridine-induced catecholamine secretion. Sodium selenite (100 µM) did not affect CCh-and veratridine-induced 22 Na+ influx, while the compound inhibited 45 Ca 2+ influx induced only by CCh, but not high K + and veratridine. Sodium selenate even at higher concentrations (1000 µM) did not affect any stimulus-induced catecholamine secretion and 45 Ca2+ influx. Thus, sodium selenite may specifically exert adverse effects, such as inhibition of physiological stimulusinduced catecholamine secretion from adrenal chromaffin cells due to inhibition of Ca 2+ influx.

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“…Until recently a relationship between trace elements and thyroid hormone metabolism has only been described for iodine, which is crucial for the formation of hormones in the thyroid gland (Neve, 1992). Zinc also may play important roles in thyroid metabolism.…”

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confidence: 99%

Zinc supplementation decreases total thyroid hormone concentration in small ruminants

Keçeci

Keskin

2002

Acta Veterinaria Hungarica

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The effect of dietary zinc (Zn) supplementation on plasma Zn and serum thyroid hormones was evaluated in healthy male Merino lambs and Angora goats. A total of 12 lambs and 12 goats were divided into two equal groups as control and Zn groups in separate experiments. The lambs and goats of the control groups were fed basal rations alone. The Zn contents of these rations prepared for lambs and goats were 40 mg/kg and 35 mg/kg in dry matter (DM), respectively. Both species of animals in the Zn groups were fed a basal ration supplemented with zinc sulphate adjusted to 250 mg Zn/kg diet in DM. The feeding trial lasted for 12 weeks in lambs and 8 weeks in goats. Blood samples were taken from the jugular vein at 4-week intervals. Both animal species in the Zn groups had higher plasma Zn values than the controls throughout the experimental period, except in the 4th week in goats. However, the levels of serum total thyroxine (T 4 ) and triiodothyronine (T 3 ) were lower in the lambs and goats of the Zn groups, except in the 4th week, as compared to those in the controls. Moreover, serum total thyroid hormone levels of the goats were higher at the 4th week than at the 8th week. Although there was a decrease in the levels of free thyroxine and triiodothyronine of both small ruminant species in the Zn groups when compared to the controls, these alterations were not statistically significant. These results may show that zinc supplementation to the diet at this dose reduces total thyroid hormone levels in small ruminants but does not yet impair the euthyroid status of the organism.

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Clinical implications of trace elements in endocrinology

Cited by 39 publications

References 58 publications

Speciation of Iodine in High Iodine Groundwater in China Associated with Goitre and Hypothyroidism

Speciation of Iodine in High Iodine Groundwater in China Associated with Goitre and Hypothyroidism

Inhibition by Selenium Compounds of Catecholamine Secretion Due to Inhibition of Ca2+ Influx in Cultured Bovine Adrenal Chromaffin Cells

Zinc supplementation decreases total thyroid hormone concentration in small ruminants

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