Clinical importance of preoperative red-cell volume distribution width as a prognostic marker in patients undergoing radical surgery for pancreatic cancer

Dang, Chao; Wang, Min; Qin, Tingting; Qin, Renyi

doi:10.1007/s00595-021-02374-7

Cited by 7 publications

(10 citation statements)

References 45 publications

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“…Many researchers have investigated the role of inflammation and inflammatory markers/indices in predicting the postoperative prognosis of various tumors, including PC (1,5,8). The ability of platelets to protect cancer cells from the immune response and facilitate their attachment to the endothelium and the antitumor role of lymphocytes support the hypothesis that PLR may be valuable in predicting prognosis in cancer patients (10,15). The mechanism underlying the prognostic value of PLR in PC remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it is well established that inflammatory activation plays a key role in carcinogenesis and the tumor microenvironment (8). Despite the fact that information is limited regarding the mechanisms of these relationships (5), a number of inflammation markers and indices, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocytemonocyte ratio (LMR), and red cell distribution width (RDW), have been investigated for their potential importance in PC prognosis and diagnosis (9,10). Many authors have identified pretreatment RDW (10), NLR (11) and PLR (12) values as being associated with OS in patients with PC.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the fact that information is limited regarding the mechanisms of these relationships (5), a number of inflammation markers and indices, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocytemonocyte ratio (LMR), and red cell distribution width (RDW), have been investigated for their potential importance in PC prognosis and diagnosis (9,10). Many authors have identified pretreatment RDW (10), NLR (11) and PLR (12) values as being associated with OS in patients with PC. Meta-analyses have also supported these suggestions by showing that high PLR, NLR, and RDW were suggestive of poor prognosis in PC (1,4,10,13).…”

Section: Introductionmentioning

confidence: 99%

“…Many authors have identified pretreatment RDW (10), NLR (11) and PLR (12) values as being associated with OS in patients with PC. Meta-analyses have also supported these suggestions by showing that high PLR, NLR, and RDW were suggestive of poor prognosis in PC (1,4,10,13). Since PLR, NLR, and RDW are easily-accessible inflammatory indices, their possible association with postoperative outcomes can be valuable for the assessment of patients with PC and treatment decisions, such as identifying candidates for either surgery or neoadjuvant therapy (5).…”

Section: Introductionmentioning

confidence: 99%

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Factors independently associated with prognosis in patients operated for pancreatic cancer: Assessing the role of various parameters including red cell distribution width, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio

Karayiğit

ÖZDEMİR²,

Dizen³

et al. 2022

Journal of Health Sciences and Medicine

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Objective: We aimed to assess whether, among other parameters, preoperative red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) values were associated with prognosis in patients operated for pancreatic cancer (PC). Material and Method: This retrospective cohort was conducted from February 1, 2016 to February 1, 2021 at the general surgery department of a university hospital in Turkey. A total of 75 patients histologically diagnosed with PC who had undergone surgery were included in the study. Results: The PLR values of patients with poorly differentiated and undifferentiated tumors were found to be higher than those with moderately and highly differentiated tumors. Also, there was a significant relationship between PLR values and the length of hospital stay. PLR values increased as the length of hospital stay increased. There was a statistically significant positive correlation between CA 19-9 levels and NLR and PLR. High total bilirubin level was related with increased risk of death, while adjuvant chemotherapy recipients had 4.049-fold lower risk of death than those without adjuvant chemotherapy. Conclusion: Our results indicate that preoperative NLR, PLR and RDW cannot be used as prognostic indicators of mortality in patients with operated PC, but high PLR appears to be associated with lower level of tumor differentiation and prolonged hospital stay. We also found that high total bilirubin was a poor prognostic factor, while adjuvant chemotherapy was a good prognostic factor. Further multicenter, prospective studies with larger sample sizes will help to verify these results.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Factors independently associated with prognosis in patients operated for pancreatic cancer: Assessing the role of various parameters including red cell distribution width, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio

Karayiğit

ÖZDEMİR²,

Dizen³

et al. 2022

Journal of Health Sciences and Medicine

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“…The prognostic value of inflammatory factors such as C-reactive protein, neutrophil to lymphocyte ratio (NLR), and red blood cell distribution width (RDW) has been assessed in various types of cancer. RDW, which reflects the variability of red blood cell size, has been reported to be associated with a worse prognosis in a variety of cancers, including pancreatic [ 11 ], colorectal [ 12 ], and breast cancers [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Is RDW a clinically relevant prognostic factor for newly diagnosed multiple myeloma? A systematic review and meta-analysis

et al. 2022

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Background Multiple myeloma (MM) is an incurable plasma cell malignancy. Red cell distribution width (RDW) is a prognostic marker in various diseases, solid tumors, and hematologic neoplasms, but its prognostic significance in MM is controversial. In this study, we aimed to assess the relationship between RDW and the clinical prognosis of MM patients through a meta-analysis. Methods Relevant literature were retrieved from PubMed, Embase, and Web of Science databases according to PRISMA guideline. All relevant parameters were extracted and combined for statistical analysis. The effect size was presented as hazard ratio (HR)/odds ratio (OR) and 95% confidence interval (CI). HR/OR > 1 in MM patients with high RDW suggested a worse prognosis. Heterogeneity test evaluation was performed using Cochran's Q test and I2 statistics. A Pheterogeneity < 0.10 or I2 > 50% suggested significant heterogeneity. P < 0.05 was considered statistically significant. Statistical analysis was performed using Stata 12.0 software. Results 8 articles involving 9 studies with 1165 patients were included in our meta-analysis. Our results suggested that elevated RDW is significantly associated with poor prognosis in MM (OS: HR = 1.91, 95%CI: 1.48–2.46; PFS: HR = 2.87, 95% CI: 2.02–4.07). A significant correlation was not found between RDW and International Staging System (ISS) staging (ISS III VS ISS I-II: OR:1.53; 95%CI:0.97–2.42). Conclusion Our results suggested that RDW is a robust predictor of newly diagnosed MM outcomes.

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Predictive value of the random forest model based on bioelectrical impedance analysis parameter trajectories for short-term prognosis in stroke patients

Yang,

Peng,

Liu

et al. 2024

Eur J Med Res

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Background The short-term prognosis of stroke patients is mainly influenced by the severity of the primary disease at admission and the trend of disease development during the acute phase (1–7 days after admission). Objective The aim of this study is to explore the relationship between the bioelectrical impedance analysis (BIA) parameter trajectories during the acute phase of stroke patients and their short-term prognosis, and to investigate the predictive value of the prediction model constructed using BIA parameter trajectories and clinical indicators at admission for short-term prognosis in stroke patients. Methods A total of 162 stroke patients were prospectively enrolled, and their clinical indicators at admission and BIA parameters during the first 1–7 days of admission were collected. A Group-Based Trajectory Model (GBTM) was employed to identify different subgroups of longitudinal trajectories of BIA parameters during the first 1–7 days of admission in stroke patients. The random forest algorithm was applied to screen BIA parameter trajectories and clinical indicators with predictive value, construct prediction models, and perform model comparisons. The outcome measure was the Modified Rankin Scale (mRS) score at discharge. Results PA in BIA parameters can be divided into four separate trajectory groups. The incidence of poor prognosis (mRS: 4–6) at discharge was significantly higher in the “Low PA Rapid Decline Group” (85.0%) than in the “High PA Stable Group “ (33.3%) and in the “Medium PA Slow Decline Group “(29.5%) (all P < 0.05). In-hospital mortality was the highest in the “Low PA Rapid Decline Group” (60%) compared with the remaining trajectory groups (P < 0.05). Compared with the prediction model with only clinical indicators (Model 1), the prediction model with PA trajectories (Model 2) demonstrated higher predictive accuracy and efficacy. The area under the receiver operating characteristic curve (AUC) of Model 2 was 0.909 [95% CI 0.863, 0.956], integrated discrimination improvement index (IDI), 0.035 (P < 0.001), and net reclassification improvement (NRI), 0.175 (P = 0.031). Conclusion PA trajectories during the first 1–7 days of admission are associated with the short-term prognosis of stroke patients. PA trajectories have additional value in predicting the short-term prognosis of stroke patients.

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Clinical importance of preoperative red-cell volume distribution width as a prognostic marker in patients undergoing radical surgery for pancreatic cancer

Cited by 7 publications

References 45 publications

Factors independently associated with prognosis in patients operated for pancreatic cancer: Assessing the role of various parameters including red cell distribution width, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio

Factors independently associated with prognosis in patients operated for pancreatic cancer: Assessing the role of various parameters including red cell distribution width, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio

Is RDW a clinically relevant prognostic factor for newly diagnosed multiple myeloma? A systematic review and meta-analysis

Predictive value of the random forest model based on bioelectrical impedance analysis parameter trajectories for short-term prognosis in stroke patients

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