Clinical investigation of oral cancer in adolescent and young adult generation

Yoshioka, Yukio; Taishi, Sakaue; Matsui, Kensaku; Tsushima, Kenji; Obayashi, Fumitaka; Hamada, Atsuko; Yamasaki, Sachiko; Hamana, Tomoaki; Sumi, Koichiro; Taku, Keisei; Koizumi, Koichi; Tani, Ryotaro; Hayashido, Yasutaka; Sasahara, Hisako; Ito, Yoku; Sado, Tomohiro; Ishida, Yasuaki; Okamoto, Kosei; Kobayashi, Masashi; Sakamoto, Akihiko; Myoken, Yoshinari; Toratani, Shigeaki; Okamoto, Tomoyoshi

doi:10.1002/osi2.1093

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…Therefore, the early detection of fatal diseases by referral from a family dentist to specialized hospital medical care is one of the indispensable functions for improving health maintenance. Yoshioka et al 13) reported that the diagnostic technique for oral cancer has improved and that oral function can be restored after treatment. Su cient oral hygiene was also reported to reduce the risk of esophageal cancer by Sepehr et al 14) .…”

Section: Prefacementioning

confidence: 99%

The causal structure of the role of physicians and dentists in the healthy longevity of elderly residents.

Hoshi

2022

Preprint

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BACKGROUNDThe significance of living a healthy and long life in an aging society is increasing. The causal structure of the role of physicians and dentists in healthy longevity is not clear.OBJECTIVEThe purpose of this research is to clarify the socioeconomic factors underlying three health factors and the relationship among these three health factors. In addition, a main purpose of this research is to clarify the causal structure between subjective health after 3 years and healthy longevity, which is a dependent variable that is defined as the survival days for the next 3 years, as an observation variable, based on the presence of a physician and/or dentist by gender.METHODFor the survey method, a self-administered questionnaire was mailed to 16,462 suburban elderly residents in Tama City, Tokyo, in September 2001. Responses were obtained from 13,066 residents (response rate of 79.4%). A similar survey was conducted in 2004. We analyzed a total of 7,905 subjects, including 3,754 males and 4,151 females aged 65 to 84, for whom we were able to clearly determine the need for long-term care after 3 years and their survival days for the next 3 years. Following these subjects for three years from 2004 to 2007, we confirmed the death dates of 278 men and 160 women.RESULTS According to this study, elderly people with desirable socioeconomic factors tended to have a family dentist. A causal structure was shown, indicating that three health factors are advisable based on socioeconomic status, and as a result, healthy longevity, including both a high level of subjective health and a reduced bedridden status, was maintained. This related structure could explain 64% of healthy longevity. In addition, a similar tendency was shown by gender. Future research will require the use of oral care and health indicators such as blood pressure and blood glucose levels. It is also expected that the external validity would be enhanced by analyzing the causal structure through intervention studies including a randomized control group.

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Section: Prefacementioning

confidence: 99%

The causal structure of the role of physicians and dentists in the healthy longevity of elderly residents.

Hoshi

2022

Preprint

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“…The role of the family dentist is not limited to supporting oral hygiene self-care. There have been reports on the detection of cancer in the oral cavity and the early detection of cancer [13,14]. Therefore, the early detection of fatal diseases by referral from a family dentist to specialized hospital medical care is one of the indispensable functions for improving health maintenance.…”

Section: Prefacementioning

confidence: 99%

“…Therefore, the early detection of fatal diseases by referral from a family dentist to specialized hospital medical care is one of the indispensable functions for improving health maintenance. Yoshioka Y, et al [13] reported that the diagnostic technique for oral cancer has improved and that oral function can be restored after treatment. Sufficient oral hygiene was also reported to reduce the risk of esophageal cancer by Sepehr A, et al [14].…”

Section: Prefacementioning

confidence: 99%

The Causal Structure of the Role of Physicians and Dentists in the Healthy Longevity of Elderly Dwellers Residents

Hoshi¹

2022

Int J Dent Oral Health

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Background: The significance of living a healthy and long life in an aging society is increasing. The causal structure of the role of physicians and dentists in healthy longevity is not clear. Objective: The purpose of this research was to clarify the socioeconomic factors underlying three health factors and the relationship among these three health factors. In addition, a main purpose of this research is to clarify the causal structure between subjective health after 3 years and healthy longevity, which is a dependent variable that is defined as the survival days for the next 3 years, as an observation variable, based on the presence of a physician and/or dentist by gender. Method: For the survey method, a self-administered questionnaire was mailed to 16,462 suburban elderly residents in Tama City, Tokyo, in September 2001. Responses were obtained from 13,066 residents (response rate of 79.4%). A similar survey was conducted in 2004. We analyzed a total of 7,905 subjects, including 3,754 males and 4,151 females aged 65 to 84, for whom we were able to clearly determine the need for long-term care after 3 years and their survival days for the next 3 years. Following these subjects for three years from 2004 to 2007, we confirmed the death dates of 278 men and 160 women. Results: According to this study, elderly people with desirable socioeconomic factors tended to have a family dentist. A causal structure was shown, indicating that three health factors are advisable based on socioeconomic status, and as a result, healthy longevity, including both a high level of subjective health and a reduced bedridden status, was maintained. This related structure could explain 64% of healthy longevity. In addition, a similar tendency was shown by gender. Future research will require the use of oral care and health indicators such as blood pressure and blood glucose levels. It is also expected that the external validity would be enhanced by analyzing the causal structure through intervention studies including a randomized control group.

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“…OLP has a female preponderance with chronic course, and erosive OLP shows a high potential for malignancy 2 3 . Therefore, the World Health Organization working group has categorized OLP as an oral potentially malignant disorder 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K

Miyahara,

Hu,

Moriyama

et al. 2023

Preprint

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Oral lichen planus (OLP) is a chronic inflammatory disease associated with T cell infiltration. The crosstalk between oral epithelium and mucosal T cells was considered to play an important role in the pathogenesis of OLP. Here, we selectively extracted the normal and lesional epithelium (LE) of buccal mucosa specimens from three patients with OLP by laser capture microdissection due to identify the pathogenic factors. Cathepsin K (CTSK) was identified as one of common upregulated genes in the LE by DNA microarray. Immunohistochemically, CTSK was distinctly detected in and around the LE, while it was rarely seen in the NE. Recent studies showed that CTSK enhanced Toll-like receptor 9 (TLR9) signaling in antigen-presenting cells, leading to Th17 cell differentiation. TLR9 expression mainly co-localized with CD123+ plasmacytoid dendritic cells (pDCs). The number of RORγt-positive cells correlated with that of CTSK-positive cells in OLP tissues. CD123+ pDCs induced the production of Th17-related cytokines (IL-6, IL-23, and TGF-β) upon stimulation with TLR9 agonist CpG DNA. Moreover, single cell RNA-sequencing analysis revealed that TLR9-positive pDCs enhanced in genes associated with Th17 cell differentiation in comparison with TLR9-negative pDCs. CTSK may induce Th17-related production of CD123+ pDCs via TLR9 signaling to promote the pathogenesis of OLP.

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Clinical investigation of oral cancer in adolescent and young adult generation

Cited by 6 publications

References 16 publications

The causal structure of the role of physicians and dentists in the healthy longevity of elderly residents.

The causal structure of the role of physicians and dentists in the healthy longevity of elderly residents.

The Causal Structure of the Role of Physicians and Dentists in the Healthy Longevity of Elderly Dwellers Residents

Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K

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