Purpose: To determine the clinical and therapeutic characteristics in adolescent and young adult (AYA) generation with oral cancer. Methods: We retrospectively studied AYA patients with oral cancer, aged 16-40 years who visited our department between 1 April 1997 and 31 December 2017, focusing on clinical characteristics including sex, age distribution, tumor site, pathological classification, stage, treatment, treatment outcome, and social rehabilitation. Results: Forty-two patients of AYA generation (19 males and 23 females), accounting for five. Seven percent of all oral cancer patients (740), were included. Most were aged 35-39 (median, 30.9) years. The most frequent site of tumor occurrence was the tongue (n = 29) and the most common histological type was squamous cell carcinoma (n = 30). Most patients had T2N0 cancer based on the TNM classification, and early stage II. Thirty-nine patients underwent radical treatment, comprising 14 cases of surgery, six of chemo-radiation therapy, four of surgery with chemotherapy, and two of surgery with radiation therapy. Conversely, nine patients underwent radical radiation therapy, comprising five cases of internal radiation therapy and four of This article is based on a study first reported in the Journal of the Japanese

Background: Tumor-infiltrating lymphocytes (TILs) have been used to predict the prognosis of solid tumors. In this study, we investigated which molecules in TILs play a role in the prognosis of patients with oral squamous cell carcinoma (OSCC). Methods: In a retrospective case-control study, we immunohistochemically evaluated the expression of CD3, CD8, CD45RO, Granzyme B, and the major histocompatibility complex class I chain-related molecule A (MICA) of the histocompatibility complex as predictors of prognosis in 33 patients with OSCC. The patients were classified as TILsHigh or TILsLow according to the number of TILs for each molecule in the central tumor (CT) and invasive margin (IM). Furthermore, MICA expression scores were determined based on the intensity of the staining. Results: CD45RO+/TIL in the nonrecurrent group were significantly higher than those in the recurrent group in the CT and IM areas (p < 0.05). The disease-free survival/overall survival rate of the CD45RO+/TILsLow group in the CT and IM areas and the Granzyme B+/TILsLow group in the IM area was significantly lower than that of the CD45RO+/TILsHigh group and the Granzyme B+/TILsHigh group, respectively (p < 0.05). Furthermore, the MICA expression score of tumors around the CD45RO+/TILsHigh group was significantly higher than that of the CD45RO+/TILsLow group (p < 0.05). Conclusions: A high ratio of CD45RO-expressing TILs was associated with a disease-free/overall survival improvement in OSCC patients. Furthermore, the number of TILs that express CD45RO was associated with the expression of MICA in tumors. These results suggest that CD45RO-expressing TILs are useful biomarkers for OSCC.

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Abstract：In the background of the abnormal intraoral hematoma formation, there exists a possible underlying severe bleeding disorders. In this report, we described a case of fibrinolytic activated disseminated intravascular coagulation (DIC)associated with an abdominal aortic aneurysm, and that of idiopathic thrombocytopenic purpura(ITP)revealed by intraoral hematoma. In both cases, a local hemostasis for abnormal bleeding from hematoma in addition to the systemic treatment was carried out. In cases presenting symptoms with abnormal intraoral hematoma and/or bleeding, it will be considered the possibility that severe hemorrhagic disease is hidden behind the patients. Thus, the early diagnosis and treatment in cooperation with a hematologist is very important．