“…Type 1 diabetes comprises 5-10 % of all diabetic cases and is the consequence of the autoimmune destruction of pancreatic beta cells, giving rise to absolute insulin deficiency (Keshtkar et al, 2019[ 19 ]; You and Henneberg, 2016[ 43 ]). Islet transplantation is considered a promising treatment for type 1 diabetes patients who face severe periods of hypoglycemia (Saravanan et al, 2017[ 33 ]). Although the transplantation of islets is backed by encouraging results, some limitations exist, such as the shortage of organ donors and the loss of islets both in the pre-transplant culture period and subsequent to transplantation (Froud et al, 2005[ 10 ]).…”