2017
DOI: 10.18520/cs/v113/i07/1267-1276
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Clinical Islet Cell Transplantation – Recent Advances

Abstract: Type-1 diabetes mellitus (T1DM) caused by autoimmune destruction of insulin-producing beta-cells essentially requires treatment with exogenous insulin therapy. Despite the education, technology and improvements in insulin formulations, patients face the ongoing life-threatening hypoglycaemia with poor quality of life as well as progressive disease leading to microand macro-vascular complications of diabetes. Islet transplantation offers an alternative therapeutic option for these patients. In this review, we d… Show more

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Cited by 2 publications
(2 citation statements)
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“…Over the last 30 years, allogeneic islet transplantation has become a firmly established treatment modality that may soon receive regulatory approval for clinical use. 1 Nevertheless, its potential impact is limited by the scarcity of suitable deceased-donor islets and the need to provide recipients lifelong systemic immune suppression therapy to prevent islet rejection.…”
mentioning
confidence: 99%
“…Over the last 30 years, allogeneic islet transplantation has become a firmly established treatment modality that may soon receive regulatory approval for clinical use. 1 Nevertheless, its potential impact is limited by the scarcity of suitable deceased-donor islets and the need to provide recipients lifelong systemic immune suppression therapy to prevent islet rejection.…”
mentioning
confidence: 99%
“…Type 1 diabetes comprises 5-10 % of all diabetic cases and is the consequence of the autoimmune destruction of pancreatic beta cells, giving rise to absolute insulin deficiency (Keshtkar et al, 2019[ 19 ]; You and Henneberg, 2016[ 43 ]). Islet transplantation is considered a promising treatment for type 1 diabetes patients who face severe periods of hypoglycemia (Saravanan et al, 2017[ 33 ]). Although the transplantation of islets is backed by encouraging results, some limitations exist, such as the shortage of organ donors and the loss of islets both in the pre-transplant culture period and subsequent to transplantation (Froud et al, 2005[ 10 ]).…”
Section: Introductionmentioning
confidence: 99%