Clinical lipidomics: realizing the potential of lipid profiling

Abstract

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The foundations and development of lipidomics

“…(e.g., ( 191 , 192 , 193 , 194 , 195 )). Readers interested in this area of work could also find the comprehensive review by Meikle in this Thematic Review series ( 196 ).…”

Clinical lipidomics – A community-driven roadmap to translate research into clinical applications

“…1 ). If we are to optimize the translational opportunities arising from these growing resources, we require synchronization of efforts to progress the field towards useful clinical applications while minimizing unnecessary work [7] . Notable past and ongoing global efforts by the lipidomics community include the LIPID MAPS initiative, which launched international lipidomics efforts, spearheading lipid classification and nomenclature, databases, standards and other resources for the international community in the nearly 20 years of its existence [8] .…”

Genetic Architecture of Untargeted Lipidomics in Cardiometabolic-Disease Patients Combines Strong Polygenic Control and Pleiotropy

“…Even though elevated blood LDL cholesterol is known to be a major risk factor for coronary heart disease and stroke, lipidomics enables a hypothesis-free strategy for broadening the search for the biomarkers associated with these diseases to a wide range of lipid species and to uncover novel targets beyond traditional lipids that can predict or reduce the risk of cardiovascular diseases [ 7 , 8 ]. Among examples of lipid classes that can be detected and quantified through lipidomic technologies, ceramides are involved in vascular inflammation and apoptosis and may have a higher potential to predict coronary heart disease than LDL cholesterol [ 9 ].…”