Abstract:Tuberculosis remains a serious world public health problem. Tuberculous meningitis (TBM) is the one of most severe forms of extrapulmonary tuberculosis. However, the insensitivity and time-consuming requirement of culturing the pathogen Mycobacterium tuberculosis, the traditional “gold standard” diagnostic test for TBM, often delays timely diagnosis and treatment, resulting in high disability and mortality rates. In our series case study, we present five pathogen-negative TBM cases who received empirical anti-… Show more
“…All the other diagnoses were exhausted, and they were started on a trial of empirical anti‐Tuberculous treatment that significantly improved their condition. 15 Likewise, our patient also displayed symptoms of paraparesis and areflexia along with worsening of his neurological status. His TB screening was negative and despite that, he showed radical improvement with anti‐tuberculous therapy that resulted in the complete resolution of symptoms, which justifies this point.…”
Section: Discussionmentioning
confidence: 50%
“…In a recent case series study published in October 2022 in China, five patients were followed up who exhibited CNS symptoms with no pathogenic isolation of TB and negative imaging. All the other diagnoses were exhausted, and they were started on a trial of empirical anti‐Tuberculous treatment that significantly improved their condition 15 . Likewise, our patient also displayed symptoms of paraparesis and areflexia along with worsening of his neurological status.…”
TBM has a very high rate of adverse sequelae if not treated immediately.Diagnosing can be challenging due to overlapping symptoms with other disease processes, and diagnostic tests are often inconclusive.
“…All the other diagnoses were exhausted, and they were started on a trial of empirical anti‐Tuberculous treatment that significantly improved their condition. 15 Likewise, our patient also displayed symptoms of paraparesis and areflexia along with worsening of his neurological status. His TB screening was negative and despite that, he showed radical improvement with anti‐tuberculous therapy that resulted in the complete resolution of symptoms, which justifies this point.…”
Section: Discussionmentioning
confidence: 50%
“…In a recent case series study published in October 2022 in China, five patients were followed up who exhibited CNS symptoms with no pathogenic isolation of TB and negative imaging. All the other diagnoses were exhausted, and they were started on a trial of empirical anti‐Tuberculous treatment that significantly improved their condition 15 . Likewise, our patient also displayed symptoms of paraparesis and areflexia along with worsening of his neurological status.…”
TBM has a very high rate of adverse sequelae if not treated immediately.Diagnosing can be challenging due to overlapping symptoms with other disease processes, and diagnostic tests are often inconclusive.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.