Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature

Buzğan, Turan; Karahocagil, Mustafa Kasım; Irmak, Hasan; Baran, Ali İrfan; Karsen, Hasan; Omer, Endashaw; Akdeniz, Hayrettin

doi:10.1016/j.ijid.2009.06.031

Cited by 544 publications

(726 citation statements)

References 25 publications

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“…Since humans are able to report symptoms, human brucellosis typically presents with arthralgia, pyrexia (undulant fever), and fatigue. In a retrospective analysis of 1,028 patients over a 10-year period in Turkey, it was found that gender differences were minimal as to the number of cases (female 52.4% vs. male 47.6%) where the mean age of cases was 33.7 ± 16.34 years [32]. Almost 70% of cases were between the ages of 13–44.…”

Section: Pathogenesis Clinical Presentation and Risk Factor In Humansmentioning

confidence: 99%

“…In one study, only five deaths out of 1,028 cases were reported [32]. The major predictor of death was the development of endocarditis.…”

Section: Pathogenesis Clinical Presentation and Risk Factor In Humansmentioning

confidence: 99%

“…In males, orchitis and epididymitis are most frequently reported and account for 6–8% of complications reported [9,32,45]. In females, pelvic abscesses and salpingitis are reported, albeit rarely [46].…”

Section: Pathogenesis Clinical Presentation and Risk Factor In Humansmentioning

confidence: 99%

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Comparisons of brucellosis between human and veterinary medicine

Hull

Schumaker

2018

Infection Ecology & Epidemiology

151

129

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Brucellosis is the world’s most widespread zoonosis, but also ranks as one of the seven most neglected diseases, according to the World Health Organization. Additionally, it is recognized as the world’s most common laboratory-acquired infection. There are a reported 500,000 incident cases of human brucellosis per year. However, true incidence is estimated to be 5,000,000 to 12,500,000 cases annually. Once diagnosed, focus is directed at treating individual patients with antibiotic regimes, yet overall neglecting the animal reservoir of disease. Countries with the highest incidence of human brucellosis are Syria (1,603.4 cases per 1,000,000 individuals), Mongolia (391.0), and Tajikistan (211.9). Surveillance on animal populations is lacking in many developed and developing countries. According to the World Animal Health Information Database, Mexico had the largest number of reported outbreaks, 5,514 in 2014. Mexico is followed by China (2,138), Greece (1,268), and Brazil (1,142). The majority of these outbreaks is Brucella abortus, the etiologic agent of bovine brucellosis. Brucellosis is an ancient disease that still plagues the world. There are still knowledge gaps and a need for better diagnostics and vaccines to make inroads towards control and eradication.

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Section: Pathogenesis Clinical Presentation and Risk Factor In Humansmentioning

confidence: 99%

“…In one study, only five deaths out of 1,028 cases were reported [32]. The major predictor of death was the development of endocarditis.…”

Section: Pathogenesis Clinical Presentation and Risk Factor In Humansmentioning

confidence: 99%

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Comparisons of brucellosis between human and veterinary medicine

Hull

Schumaker

2018

Infection Ecology & Epidemiology

151

129

View full text Add to dashboard Cite

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“…Una respuesta adecuada a terapia anti brucelosis también se aceptó como criterio diagnóstico en aquellos pacientes con cultivos negativos o con serología en títulos no significativos 8 .…”

Section: Materials Y Métodosunclassified

Brucelosis en Chile: Descripción de una serie de 13 casos

Olivares

Vidal

Sotomayor

et al. 2017

Rev. chil. infectol.

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“…Brucellosis may infect almost all of the organs and may cause various complications (1,2). Capillary leak syndrome (CLS) is a rare medical condition where the number and size of pores in the capillaries are increased leading to a leakage of fl uid from the blood to the interstitial fl uid, resulting in dangerously low blood pressure, edema and multiple organ failure due to limited perfusion (3).…”

mentioning

confidence: 99%

A case of brucellosis complicated with fatal capillary leak syndrome

Karsen¹,

St²,

Calisur³

et al. 2012

BLL

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Brucellosis may involve multiple organs and progresses with complications. Brucella endocarditis, disseminated intravascular coagulopathy (DIC) and chronic renal insuffi ciency are rare complications of brucellosis. Capillary leak syndrome due to brucellosis is seen even more rarely and up to this date, only one case has been reported. Our case will probably be the second. In this article, a case of brucellosis associated with the development of DIC, infective endocarditis and capillary leak syndrome is presented. Although antimicrobial treatment with ceftriaxone, doxycycline and rifampicine in intensive care unit, the patient died. As the reporting of capillary leak syndrome due to brucellosis is very rare, this case is regarded as valuable to be presented and will serve to call attention to this issue (Ref. 15). Full Text in PDF www.elis.sk.

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Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature

Cited by 544 publications

References 25 publications

Comparisons of brucellosis between human and veterinary medicine

Comparisons of brucellosis between human and veterinary medicine

Brucelosis en Chile: Descripción de una serie de 13 casos

A case of brucellosis complicated with fatal capillary leak syndrome

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