Clinical mortality risk factors of variceal upper gastrointestinal bleeding in a Malagasy surgical intensive care unit

Abstract

Background Variceal upper gastrointestinal bleeding is a dreadful complication of portal hypertension with a significant morbidity and mortality. Different prognostic scores can be used. However, in the local context of Madagascar, the completion of paraclinical investigations can be delayed by the limited financial means of patients. Hence, determining clinical mortality risk factors of variceal upper gastrointestinal bleeding could be interesting. The aim of the study was to evaluate the clinical mortality risk factors of variceal gastrointestinal bleeding (VUGIB). Method An observational, cohort retrospective study was conducted over an 8-year period (2010–2017), at the surgical intensive care unit of the J.R. Andrianavalona University Hospital, Antananarivo, in patients admitted for VUGIB confirmed by upper gastrointestinal endoscopy and whose clinical examination was performed at admission. The primary endpoint was intensive care unit (ICU) mortality. Univariate analysis and multivariate logistic regression analysis were performed to identify risk factors for ICU mortality, with OR defining odds ratio. A p value <0.05 was considered significant. Results 1920 patients were admitted for gastrointestinal bleeding of any digestive causes; the source of bleeding was variceal in 269 patients (14%). The predominantly male population (sex ratio = 2.5), aged 47.1 ± 13.7 years was mostly American Society of Anesthesiologists (ASA) 1 classification (58.4%). In 56.5% of patients, the gastrointestinal bleeding had not occurred before. The mortality rate was 16.0%. Three major clinical factors of mortality were identified: previous endoscopic band variceal ligation (OR = 12.57 [2.18–72.58], p = 0.005), tachycardia >120 bpm (OR = 2.91 [1.04–8.14], p = 0.041), and ascites (OR = 3.80 [1.85–7.81], p < 0.001). Conclusion Upper gastrointestinal bleeding may be life-threatening. The mortality scores are certainly useful; however, the identification of clinical factors is interesting in countries like Madagascar, pending the results of paraclinical investigations.

Development and validation of a nomogram for predicting overall survival in cirrhotic patients with acute kidney injury

“…Therefore, identifying cirrhotic patients with AKI who are at high risk of mortality is very important and may be helpful for providing timely medical interventions to improve the prognosis of these patients. Currently, many studies have investigated risk factors for mortality in patients with cirrhosis[ 10 ] and other complications, such as gastroesophageal variceal bleeding[ 11 , 12 ], ascites[ 13 ], bacterial infections[ 14 ] and metabolic acidosis[ 15 ]. Moreover, a number of studies have focused on identifying the risk factors for the development of AKI in patients with cirrhosis[ 16 - 19 ] and other conditions[ 20 - 22 ].…”

Risk Factors for Mortality Among Upper Gastrointestinal Bleeding Patients : Literature Review

“…The non-variceal group occurs due to mucosal structure damage that extends into blood vessels [4], which can be caused by various factors such as Helicobacter pylori (H Pylori) [3]. Meanwhile, the variceal group can occur as a complication of portal hypertension [5].…”