Clinical Observation on the Improvement of Serum Sex Hormone and Ovarian Function in Premature Ovarian Failure Patients with Deficiency-Cold Syndrome by Combining Wenjing Decoction with Tiaobu Chongren Acupuncture and Moxibustion

Abstract

Objective. To explore the effect of Wenjing Decoction and Tiaobu Chongren acupuncture and moxibustion therapy on serum sex hormones and ovarian function recovery in premature ovarian failure (POF) patients with deficiency-cold syndrome. Methods. From February 2018 to October 2019, 119 POI patients with deficiency-cold syndrome who met the selection criteria were randomly divided into the control group (n = 59) and the observation group (n = 60). The control group was treated with hormone replacement therapy, and the observation group was treated with Wenjing Decoction and Tiaobu Chongren acupuncture and moxibustion therapy on the basis of the control group. Both groups were treated continuously for 3 months. After treatment, the clinical efficacy of the two groups was compared, the Chinese medicine syndrome score, serum estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-mullerian hormone (AMH) and bilateral antral follicle count (AFC), mean ovarian volume, and endometrial thickness of the two groups before and after treatment were compared. Result. The effective rate of the observation group (93.10%) was higher than that of the control group (77.59%) ( P < 0.05 ). After treatment, the index scores of traditional Chinese medicine syndromes in two groups were lower than before ( P < 0.05 ), and the observation group was lower than the control group ( P < 0.05 ). The serum E2 and AMH levels in the two groups increased, while FSH and LH levels decreased compared with before treatment, and the observation group improved significantly compared with the control group ( P < 0.05 ). The bilateral AFC, mean ovarian volume, and endometrial thickness of the two groups increased compared with before treatment, and the observation group was higher than the control group ( P < 0.05 ). Conclusion. On the basis of hormone replacement therapy, the combination of Wenjing Decoction and Tiaobu Chongren acupuncture and moxibustion therapy is effective in treating POF patients with deficiency-cold syndrome, which can effectively regulate their serum sex hormone levels and promote the recovery of ovarian function.

Current Research on Complementary and Alternative Medicine in the Treatment of Premature Ovarian Failure: An Update Review

“…Professor Li [ 68 ] used the empirical formula “Yangshu Bazhen Decoction,” which was modified from the ancient formula “Bazhen decoction,” to treat POF by emphasizing the harmony of liver and kidney, paying attention to emotional treatment, balancing yin and yang, and regulating Chong Ren, which achieved good curative effects. In addition, Danggui Buxue decoction [ 69 ], Siwu decoction [ 70 ], Wenjing decoction [ 71 ], Bushen Jianpi formula [ 72 ], and other TCM decoctions have good effects in the treatment of POF, and these emphasize the flexible composition and good curative effect of TCM decoctions and fully demonstrate the theory of disease differentiation and treatment using TCM. The effect of TCM decoctions on POF is summarized in Table 2 .…”

Complementary and Alternative Medicine for Premature Ovarian Insufficiency: A Review of Utilization and Mechanisms

“…All of these have a positive effect on POI (Table 4). Based on a large number of clinical and animal experiments, the different mechanisms of acupuncture treatment for POI include relaxation of the meridians and promotion of blood circulation, regulation of the hypothalamus-pituitaryovarian axis, improvement of hormone levels, increasing the production of the antiapoptotic factor Bcl-2, and reducing the production of the proapoptotic factor Bax in ovarian granulosa cells [72][73][74][75][76].…”

Retracted: Clinical Observation on the Improvement of Serum Sex Hormone and Ovarian Function in Premature Ovarian Failure Patients with Deficiency‐Cold Syndrome by Combining Wenjing Decoction with Tiaobu Chongren Acupuncture and Moxibustion

“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”